Interleukin-6 and Cardiovascular Diseases

Kanda, Tsugiyasu; Takahashi, Takashi

doi:10.1536/jhj.45.183

Cited by 244 publications

(188 citation statements)

References 55 publications

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“…In our study, occlusion of the coronary artery was associated with increased serum levels of TNF-a and Il-6 ( Fig. 4A and 4B), indicating that the pro-inflammatory cytokine expression pathway was upregulated, as reported in previous studies [9,13,14]. Treatment with GXEH (15 g/kg) significantly reduced serum levels of TNF-a and Il-6 ( Fig.…”

Section: Discussionsupporting

confidence: 88%

“…Higher levels of pro-inflammatory mediators, including Il-6 and TNF-a, are risk markers for coronary artery disease, and might be related to increased morbidity and mortality in cardiac disease [26]. Il-6 is a key inflammatory factor, and has been implicated in the pathogenesis and progression of CVD [13]. In particular, increased expression of Il-6 in cardiac tissue is associated with myocardial ischemia [13].…”

Section: Discussionmentioning

confidence: 99%

“…Il-6 is a key inflammatory factor, and has been implicated in the pathogenesis and progression of CVD [13]. In particular, increased expression of Il-6 in cardiac tissue is associated with myocardial ischemia [13]. TNF-a is also an acute phase reactive protein and is one of the important pathological factors in inflammatory responses [4].…”

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory Effect of Guan-Xin-Er-Hao via the Nuclear Factor-Kappa B Signaling Pathway in Rats with Acute Myocardial Infarction

et al. 2010

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Abstract:A traditional Chinese medicine, Guan-Xin-Er-Hao (GXEH), is a famous multiple target therapeutic polypharmaceutical. Our aim was to evaluate whether or not oral administration of GXEH has an anti-inflammatory effect associated with blockade of nuclear factor-kappa B (NF-κB), and to investigate the NF-κB-mediated pro-inflammatory cytokines expression pathway during acute myocardial infarction (AMI) in rats. Sprague-Dawley rats were randomly assigned to four groups: oral GXEH administered at 15 or 5 g/kg, the vehicle control and sham-operated groups. Thirty minutes after giving GXEH or 0.9% NaCl (p.o.) once, coronary arteries were occluded except for the sham-operated rats. We measured 24-h infarct size, 3-h expression of NF-κB protein in the myocardial left ventricular tissues and serum levels of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and C-reactive protein (CRP). Compared with rats receiving vehicle, rats administered 15 g/kg GXEH had significantly reduced 24-h infarct size, expression of NF-κB protein and serum concentrations of TNF-a, IL-6, and CRP. GXEH at 5 g/kg did not have a significant effect on these parameters. In conclusion, GXEH exhibited an anti-inflammatory effect through inhibition of the NF-κB-mediated signaling pathway leading to downregulation of pro-inflammatory cytokine expression. These findings provide new evidence of the cardioprotective effect of GXEH through reduction of infarct size by mediating lots of endogenous materials via multiple pathways to act on myocardial cells in the treatment of cardiovascular disease.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Anti-Inflammatory Effect of Guan-Xin-Er-Hao via the Nuclear Factor-Kappa B Signaling Pathway in Rats with Acute Myocardial Infarction

et al. 2010

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“…Since IL-6 is a potent stimulus for CRP expression in liver, the increased vascular production of IL-6 may represent a positive feedback mechanism for the continued production of CRP from the liver. 17) Several recent studies have indicated that CRP and proinflammatory cytokines such as IL-6 were elevated in OSAS as well as obesity. [13][14][15]18,19) Thus, obesity and OSAS are inflammatory states, as evidenced by elevated levels of serum markers of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

<b>Elevated C-Reactive Protein Levels and Increased Cardiovascular Risk in Patients With Obstructive Sleep Apnea Syndrome</b>

et al. 2005

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SUMMARYObstructive sleep apnea syndrome (OSAS) is associated with cardiovascular morbidity and mortality. Inflammatory processes associated with OSAS may contribute to cardiovascular morbidity in these patients. C-reactive protein (CRP) is an important serum marker of inflammation. We tested the hypothesis that patients with OSAS have increased plasma CRP.After 173 male subjects underwent polysomnography, 94 were considered to have OSAS (apnea-hypopnea index (AHI) > 5), 38 cardiovascular disease (CVD), and 56 without CVD. Seventy-nine subjects were considered not to have OSAS (AHI < 5) and from among these 57 patients without CVD were enrolled as control subjects.Serum CRP levels were significantly elevated in the OSAS + CVD group compared to the two other groups (P < 0.05). When we evaluated the association between the serum CRP level and severity of OSAS, CRP levels were positively correlated with AHI in OSAS patients (r = 0.61, P < 0.001) OSAS, as a marker of inflammation and cardiovascular risk, is associated with elevated levels of CRP. According to these results, the link between cardiovascular morbidity and OSAS may be explained by the coexistence of other cardiovascular risk factors such as circulating CRP levels. (Int Heart J 2005; 46: 801-809) Key words: CRP, Sleep apnea, Inflammation OBSTRUCTIVE sleep apnea syndrome (OSAS) is a common disorder that affects both children and adults. It is characterized by periods of breathing cessation (apnea) and periods of reduced breathing (hypopnea). Both types of events have similar pathophysiology and are generally considered to be equal with respect to their impact on patients. There are several methods of quantifying the severity of the disorder such as measuring the number of apneas and hypopneas per hour of sleep (the apnea-hypopnea index: AHI), the severity of oxygen desatFrom the

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“…Elevated circulating levels of IL6 have been demonstrated in HF patients, and their serum level expression in cardiac tissue has been correlated with severity of left ventricular function and progression of HF 27 . IL6 has a negative inotropic effect as a consequence of an IL6-induced myocardium hypocontractile state, which explains why patients with uncompensated HF have higher IL6 levels than patients in the recovery phase 28 , reflecting the hemodynamic deterioration in HF patients 29 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

Bravo-Tobar

Parra²,

Pérez

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients. Methods: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF. Results: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF. Conclusions: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases.

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Interleukin-6 and Cardiovascular Diseases

Cited by 244 publications

References 55 publications

Anti-Inflammatory Effect of Guan-Xin-Er-Hao via the Nuclear Factor-Kappa B Signaling Pathway in Rats with Acute Myocardial Infarction

Anti-Inflammatory Effect of Guan-Xin-Er-Hao via the Nuclear Factor-Kappa B Signaling Pathway in Rats with Acute Myocardial Infarction

<b>Elevated C-Reactive Protein Levels and Increased Cardiovascular Risk in Patients With Obstructive Sleep Apnea Syndrome</b>

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure

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