Interleukin-6 and insulin resistance in obese adolescents

Takumansang, Raynald; Warouw, Sarah M.; Lestari, Hesti

doi:10.14238/pi53.5.2013.06

Cited by 7 publications

(7 citation statements)

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“…Despite finding high serum levels of IL-6 in obese compared to non-obese subjects in the study conducted by Takumansang et al ( 20 ), they found no association between these levels and insulin resistance which is contrary to the findings of the present study. In addition, contrary to the present study, Neeland et al ( 27 ) reported a normal hormonal, inflammation, and immune profile in children with MHO.…”

Section: Discussioncontrasting

confidence: 99%

Circulating miR‑15b, Annexin A1, procalcitonin and interleukin‑6 levels differentiate children with metabolically unhealthy obesity from those with metabolically healthy obesity: A case‑control study

et al. 2022

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The present study assessed serum miR-15b, Annexin A1, procalcitonin, and interleukin-6 (IL-6) levels in children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and compared them to these levels in a non-obese healthy control group. It also tested the ability of each of these parameters to early differentiate children with MUO from those with MHO. The present study included 620 children [434 males (70%) and 186 females (30%); aged 9-15 years] divided into the following groups: G1, healthy non-obese controls (n=200); G2, MHO (n=246); G3, MUO (n=174). Serum miR-15b, Annexin A1 procalcitonin, IL-6, and other metabolic parameters levels were measured, and clinical examinations were conducted for all of the children. After testing the normality of the variable, Kruskal-Wallis one-way-ANOVA, and Spearman correlation coefficients were used. The area under the receiver operating characteristic curve (AUC) was determined to test the variable's ability to differentiate MUO from MHO. miR-15b, procalcitonin, and IL-6 levels were significantly higher while Annexin A1 levels were significantly lower in G2 and G3 when compared to G1, and in G3 when compared to G2. These levels were positively correlated (Annexin A1 was negatively correlated) with body mass index (BMI) and waist circumference percentiles, and with serum levels of LDL-cholesterol, glucose, HbA1c, insulin, and C-reactive protein (CRP) and with the homeostasis model of insulin resistance (HOMA-IR). The AUC was 0.92, 0.84, 0.82, and 0.67 for miR-15b, Annexin A1, procalcitonin, and IL-6, respectively. In conclusion, determination of serum miR-15b, Annexin A1, and procalcitonin levels could differentiate children with MUO from those with MHO. This may help the early management of these cases and their accompanying complications.

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Section: Discussioncontrasting

confidence: 99%

Circulating miR‑15b, Annexin A1, procalcitonin and interleukin‑6 levels differentiate children with metabolically unhealthy obesity from those with metabolically healthy obesity: A case‑control study

et al. 2022

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“…However, this type of BCFA is decreased in subjects with obesity. IL-6 is a major inflammatory mediator involved in obesity-related chronic inflammation, which may result in an increased risk of cardiovascular complication, insulin resistance, and type 2 diabetes [ 35 , 36 ]. Until now, several physiological or pathological factors were connected with the IL-6 level, including hormones, diet, exercise, and stress [ 37 , 38 , 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…For example, 15-lipoxygenase converts arachidonic acid (AA) into 15-hydroxyeicosatetraenoic acid (15(S)-HETE), a known pro-inflammatory molecule [ 52 , 53 , 54 ]. Studies have shown that the level and activity of LOX-15 are increased in mice on a high-fat diet and obese patients [ 35 ]. This study has shown for the first time that a reduced level of BCFA in obese subjects can be one of the possible molecular mechanisms of this phenomenon.…”

Section: Resultsmentioning

confidence: 99%

Branched-Chain Fatty Acids Alter the Expression of Genes Responsible for Lipid Synthesis and Inflammation in Human Adipose Cells

2022

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Recently, we have demonstrated a decreased level of iso-branched-chain fatty acids (iso-BCFAs) in patients with excessive weight. However, it is still unclear whether BCFAs may influence lipid metabolism and inflammation in lipogenic tissues. To verify this, human visceral adipocytes were cultured with three different concentrations of selected iso-BCFA (14-methylpentadecanoic acid) and anteiso-BCFA (12-methyltetradecanoic acid), and then the expression of genes associated with lipid metabolism (FASN—fatty acid synthase; SREBP1—sterol regulatory element-binding protein 1; SCD1—stearoyl-CoA desaturase; ELOVL4—fatty acid elongase 4; ELOVL6—fatty acid elongase 6; FADS2—fatty acid desaturase 2; FADS1–fatty acid desaturase 1) and inflammation (COX-2—cyclooxygenase 2; ALOX-15—lipoxygenase 15; IL-6—interleukin 6) were determined. This study demonstrates for the first time that incubation with iso-BCFA decreases the expression of adipocyte genes that are associated with lipid metabolism (except FASN) and inflammation. These findings suggest that changes in the iso-BCFA profile in obese patients may contribute to adipose inflammation and dyslipidemia. Further studies should evaluate whether iso-BCFA supplementation in obese patients would be beneficial.

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“…In male highly significant increasing appeared in IL-6 than control groups because adipose tissue is known to be the main source of serum IL-6, at approximately 25% of total serum IL-6. Thus, higher IL-6 levels may be due to the increased adipose tissue (25) . Concentration of leptin is significantly correlated with IL-6 in boys illustrated in table (4) this may be due to that leptin linked to adiposity strongly, where levels are involved by size of adipocyte and mass of fat amounts.…”

Section: Discussionmentioning

confidence: 99%

Levels of Leptin and IL-6 With Some Biochemical Parameters in Iraqi Obese Children

2020

IJFMT

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Obesity in children is attended by increased circulating leptin concentrations. Girls have higher leptin Concentrations than boys. IL-6 levels related positively with BMI and percent fat mass (PFM).The Objective: Was to detect the serum IL-6 and levels of leptin among girls and boys as obese and other biochemical parameters related with obesity. Methodology: This study involved 60 children were classified into 2 groups; 30 obese ones (fifteen girls and boys fifteen) and 30 control (fifteen girls and fifteen boys) with years of seven-fifteen old who attended to the Obesity Research and Treatment Unit/ Al kindy Medical College, during the period January 2017 -July 2017. A clinical examination and diagnosis were done for each patient by the consultant medical staff and the biochemical laboratory examination results (FBS, blood urea, serum creatinine, lipid profile, serum GOT, serum GPT, SCa and uric acid) were as a routine work. They compared with 30 healthy children with approximate age with patients. The sera were assessed for IL-6 and leptin by an ELISA kit. Results: Showed no significant differences among obese children (boys and girls) except the GPT and GOT were both higher significantly (P<0.05) in male (42.46±34.27 and 33.3±13.6) than in girls (53.6 ±75.1 and 29.9±14.1). Whereas, obese girls revealed a significant increasing in (

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Interleukin-6 and insulin resistance in obese adolescents

Cited by 7 publications

References 0 publications

Circulating miR‑15b, Annexin A1, procalcitonin and interleukin‑6 levels differentiate children with metabolically unhealthy obesity from those with metabolically healthy obesity: A case‑control study

Circulating miR‑15b, Annexin A1, procalcitonin and interleukin‑6 levels differentiate children with metabolically unhealthy obesity from those with metabolically healthy obesity: A case‑control study

Branched-Chain Fatty Acids Alter the Expression of Genes Responsible for Lipid Synthesis and Inflammation in Human Adipose Cells

Levels of Leptin and IL-6 With Some Biochemical Parameters in Iraqi Obese Children

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