Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Chatzopoulos, Georgios S.; Doufexi, Aikaterini-Ellisavet; Wolff, Larry F.; Kouvatsi, Anastasia

doi:10.1590/1807-3107bor-2018.vol32.0011

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…Xiao and collaborators (2009) stressed that there is still not sufficient evidence to attribute the C allele (rs1800796) a protective role, since its frequency was not significantly different among the groups in a survey conducted with Chinese, including individuals with CPD. Similar results were obtained in other surveys with populations in Asia and Europe, evaluating the association of rs1800796 with CPD Chatzopoulos et al, 2018). Also noteworthy, is the analysis of Ferrari and collaborators (2003), who detected increased IL-6 activity in vitro, conditioned by the C allele (rs1800796), resulting in the increase of the C-reactive protein level, which is a marker of bone resorption, suggesting the variant is related to chronic diseases.…”

Section: Discussionsupporting

confidence: 79%

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Manso¹,

Hannum²,

Fortes³

et al. 2020

Genet. Mol. Res.

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©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 19 (3): gmr18568 J.A.X. Manso et al. 2 periogram, previously elaborated, together with a questionnaire concerning habits and life style. The DNA of the samples was genotyped using PCR-RFLP and qPCR, for each molecular marker. A significant trend to develop CPD was detected for individuals who brush their teeth less than twice a day. The allele of minor frequency of the variants rs1143634, rs1800796, and rs2227539 were associated with CPD, revealing a significant predictive effect (P < 0.05). The most significant findings involved the T (rs1143634) and C (rs1800796) alleles, which were associated with increased risk, when examined individually and together. We concluded that this is a multifactorial disease, although the genetic influence was predominant.

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Section: Discussionsupporting

confidence: 79%

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Manso¹,

Hannum²,

Fortes³

et al. 2020

Genet. Mol. Res.

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“…In oral dysbiosis, the presence of CP is a hallmark that is characterized by a steady inflammatory condition promoted by an increased colonization of subgingival biofilms and dental structures by a variety of pathogens both Gram-negative and Gram-positive, anaerobes, and aerobes. The disease has a sturdy progressive evolution based on both the level of host immune responses and the increased accumulation of bacteria and their virulence [23]. By common accordance the most common pathogenic strains involved in CP are P. gingivalis, T. denticola, and T. forsythia.…”

Section: Discussionmentioning

confidence: 99%

Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients

et al. 2020

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Chronic periodontitis (CP) is a complex pathology with a significant impact worldwide causing bone loss. Oral dysbiosis is a highly inflammatory condition associated to a long-term insulting infection and represents an underestimated CP key factor associated with an imbalance of pro-inflammatory and anti-inflammatory gene responses. The presence of a single nucleotide polymorphisms (SNPs) in the promoter region of interleukin 10 (IL-10) gene −1082, −819, and −592 was a possible determinant cause. This translational research aimed to provide outcomes on the role of IL-10 gene expression in bone loss diseases in patients affected by CP. Caucasian patients (n = 96) affected by CP were recruited from the Italian population. The subgingival samples were collected using the Bacterial Periodontal Assessment by Biomolecular Diagnostic® and the characterization of a set of 15 bacterial DNA responsible of periodontitis was performed by real-time multiplex PCR. In addition, two viruses, Epstein–Barr Virus (EBV) and Herpes Simplex Virus 1 (HSV-1), and a pathogenic fungi (Candida albicans) were included as a part of our panel. Our results confirmed an existing association between IL-10 gene polymorphisms and polymorphism of tumor necrosis factor alpha (TNFα), interleukin 1α-β-RN (IL-1α-β-RN), collagen type-l alpha (COLIA1), and vitamin D receptor (VDRs) genes in CP. Further studies are needed to improve diagnosis and endorse more effective therapeutic procedures for periodontal disease.

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“…IL-1β causes hypoexpression of IL-10, which is an anti-inflammatory cytokine, by periodontal ligament cells. [14,15] This amplifies the process of destruction of periodontal tissues. Periodontal ligament cells stimulated by inflammatory cytokines can cause bone resorption via RANKL.…”

Section: Resultsmentioning

confidence: 99%

Melatonin as an index of periodontal disease

Franco

Bollero

2020

European Journal of General Dentistry

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Periodontal disease affects the supporting tissues of the tooth. The clinical manifestation varies from gingivitis to periodontitis. Periodontal disease is triggered by bacterial infection that releases toxins. The imbalance between oxidants and antioxidants determines the progression of periodontal disease. Melatonin (MEL) (N-acetyl-5-methoxytryptamine) is a hormone in the human body. Its production takes place in various organs including the retina, gastrointestinal tract, bone marrow, leukocytes, lymphocytes, skin, and principally pineal gland. Its main function is the regulation of circadian and seasonal rhythm, body weight, reproduction, bone metabolism, and tumor growth. An important function of melatonin is the ability to reduce oxidative stress. The aim of this work is to explain if there are differences in salivary melatonin concentration between periodontal and healthy individuals. The study was conducted utilizing the main scientific databases (PubMed, MEDLINE, and Web of Science). The time window considered for the electronic search was from March 1, 2007, to March 1, 2020. The work takes into account 6 works on the disease. Other studies were excluded as they did not meet the inclusion criteria. Studies revealed a concentration of salivary melatonin compared to patients with periodontal disease. Studies agree that the concentration of melatonin is lower in people with periodontal disease. Only one study showed no difference in concentration. Melatonin, therefore, has a protective effect on the periodontium thanks to its antioxidant properties. The salivary measurement of melatonin could be a useful tool for early detection. It can also be used as a therapy to improve the symptoms of periodontal disease.

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Interleukin-6 and interleukin-10 gene polymorphisms and the risk of further periodontal disease progression

Cited by 14 publications

References 33 publications

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Research Article Environmental factors and polymorphisms of interleukin genes contribute to susceptibility to chronic periodontal disease

Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients

Melatonin as an index of periodontal disease

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