Interleukin-6 and interleukin-8 blood levels&amp;rsquo; poor association with the severity and clinical profile of ex-smokers with COPD

Moraes, Maria Rosedália de; Costa, Adeliane Castro da; Corrêa, Krislainy de Sousa; Junqueira-Kipnis, Ana Paula; Rabahi, Marcelo Fouad

doi:10.2147/copd.s64135

Cited by 22 publications

(19 citation statements)

References 36 publications

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“…Our findings are consistent with those of others who have shown elevated levels of serum cytokines in COPD, particularly with regard to IL-6, IL-8, TNF α , and VEGF [ 11 – 16 , 18 , 20 ]. We found certain individual circulating cytokines (particularly TNF α and IL-1 β ) to be significantly elevated in concentration in the serum of some COPD patients (and some current smokers not diagnosed with COPD), and these may serve as markers of particularly significant systemic inflammation.…”

Section: Discussionsupporting

confidence: 93%

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Selvarajah

Todd

Tighe

et al. 2016

Mediators of Inflammation

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Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFα and IL-1β) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.

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Section: Discussionsupporting

confidence: 93%

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Selvarajah

Todd

Tighe

et al. 2016

Mediators of Inflammation

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“…Greater levels of serum IL-6 also were reported in subjects with stable chronic obstructive pulmonary disease who had a history of greater smoking burden, bronchitis phenotype, and lower body mass index. 23 In addition, lung transplant recipients with early lung allograft dysfunction had greater baseline IL-6 and IL-8 levels compared with lung transplant recipients without dysfunction. 24 Studies that examine longitudinal measurements of serum IL-6 and IL-8 may help determine variability of serum cytokine levels over time, the impact of elevated inflammatory cytokines on disease outcomes, and response to treatment in people with A-T.…”

Section: Discussionmentioning

confidence: 95%

Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia

McGrath‐Morrow

Collaco

Detrick

et al. 2016

The Journal of Pediatrics

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Objective To evaluate the potential link between systemic inflammation and impaired lung function in people with ataxia-telangiectasia (A-T), we hypothesized that serum levels of interleukin (IL)-6, a proinflammatory cytokine, would correlate inversely with lung function in subjects with A-T. Study design Consecutive subjects with A-T were recruited from the Johns Hopkins Outpatient A-T Clinical Center. Serum levels of IL-6 and 8 were measured by enzyme-linked immunosorbent assay. Spirometry was performed in subjects ≥6 years of age on the same day that serum was obtained for measurements of cytokines. Results Approximately 80% of subjects had elevated serum IL-6 levels (>1.0 pg/mL). No association was found between elevated IL-6 and age. Elevated IL-8 levels were found in 23.6% of subjects, and all subjects with elevated IL-8 levels had elevated IL-6 levels. Subjects with elevated IL-6 levels (mean: 6.14 ± 7.47 pg/mL) had significantly lower mean percent forced vital capacity (FVC%, 50.5% ± 17.8%) compared with subjects with normal serum IL-6 levels (FVC% of 66.2 ± 16.1, P = .018). Greater IL-6 levels were associated with lower FVC% even after adjustment for receiving gamma globulin therapy (P = .024) and supplemental nutrition (P = .055). Conclusions An association was found between elevated serum IL-6 levels and lower lung function in subjects with A-T. In addition, subjects with both elevated IL-6 and IL-8 had the lowest mean lung function. These findings indicate that markers for systemic inflammation may be useful in identifying individuals with A-T at increased risk for lower lung function and may help in assessing response to therapy.

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“…Among pro-inflammatory cytokines, interleukin-8 (IL-8, CXCL8), a member of the CXC chemokine family, plays a pivotal role in COPD pathogenesis [ 14 , 15 ]. IL-8 is a major chemoattractant to neutrophils, which are responsible for inducing and sustaining the inflammatory state [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of tobacco smoke induce the production of interleukin-8 in human bronchial epithelium, 16HBE cells

Zhou¹,

Xiao²,

Xu³

et al. 2016

Tob. Induced Dis.

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BackgroundInterleukin-8 (IL-8) functions as a major chemoattractant and plays pivotal roles in the initiation and development of chronic obstructive pulmonary disease (COPD), and tobacco smoke is a most risk factor contributing to the development of COPD. Hence, we have screened some of the tobacco smoke-derived chemical compounds that potentially induce the production of IL-8 in human bronchial epithelium, 16HBE cells.MethodsTwenty-eight hazardous smoke components belonging to 9 classes including nicotine, ammonia, aromatic amines, polycyclic aromatic hydrocarbons, phenols, carbonyls, hydrocyanic acid, nitrosamines and other volatile organics were used in the experiments. Proliferation of 16HBE cells was determined by cell counting kit-8 kit, luciferase activity was measured in IL-8 reporter gene-expressing 16HBE cells, and IL-8 levels in culture supernatants were quantified by enzyme-linked immunosorbent assay.ResultsAt the non-toxic dosages, chemical compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics dose-dependently increased IL-8 reporter gene expression. Consistently, the representative compounds belonging to nicotine, aromatic amines, benzopyrene, phenols, aldehydes, and some other volatile organics significantly and dose-dependently increased IL-8 levels in the culture supernatants of 16HBE cells, among these compounds, benzopyrene is a most potent stimulator for inducing IL-8 production.ConclusionsThe present study has identified particular tobacco smoke constituents responsible for inducing the IL-8 production in human bronchial epithelium, which might help shed light on the pathogenesis of tobacco smoke-induced COPD.

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Interleukin-6 and interleukin-8 blood levels’ poor association with the severity and clinical profile of ex-smokers with COPD

Cited by 22 publications

References 36 publications

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia

Chemical constituents of tobacco smoke induce the production of interleukin-8 in human bronchial epithelium, 16HBE cells

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