Interleukin-6 bedside testing in women at high risk of preterm birth

Vousden, Nicola; Chandiramani, Manju; Shennan, AH

doi:10.1136/adc.2010.189761.17

Cited by 4 publications

(5 citation statements)

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“…were measured mainly in amniotic fluid or maternal serum. Other studies have analyzed the relations between vaginal cytokines and infection or preterm delivery in cases of PPROM [24][25][26][27][28]. They have some positive results but included fewer subjects and used heterogeneous thresholds for positive results; consequently, their quantitative measurement methods are not easily reproducible.…”

Section: Table 2bmentioning

confidence: 99%

Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Kayem

Batteux

Girard

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Table 2bmentioning

confidence: 99%

Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Kayem

Batteux

Girard

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Additionally, some investigators have reported that IL-6 determinations can be performed at the bedside. [14][15][16] Despite the fact that bedside IL-6 has been tested on the cervicovaginal fluid of PPROM pregnancies, there is a paucity of information on the diagnostic and prognostic value of this test of amniotic fluid retrieved by transabdominal amniocentesis form PPROM pregnancies. [13][14][15] An accurate and rapid IL-6 bedside test would be of great clinical utility in predicting PPROM complications.…”

mentioning

confidence: 97%

Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes

Kacerovský

Musilová

Hornychová

et al. 2014

American Journal of Obstetrics and Gynecology

101

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“…There have been contradictory results concerning IL-6 levels as an indicator of preterm birth. IL-6 concentrations in cervicovaginal secretions have been observed to be significantly higher in women with preterm birth and in women with visible fetal membranes compared with women with a closed external os [12]. In addition, high levels of IL-6 have been reported in cervicovaginal fluid which was found to have a reverse correlation with the cervical length [31].…”

Section: Discussion ▼mentioning

confidence: 98%

“…Concentrations of IL-6 have been reported to be elevated in amniotic fluid, cervical fluid, and cord plasma, particularly in response to intraamniotic inflammation and microbial invasion of the intraamniotic cavity. Preterm births were found in women with visible fetal membranes that had high IL-6 (cut-off: 56 pg/ml) levels in cervicovaginal secretions, suggesting that IL-6 may be useful in managing patients with visible membranes and preterm premature rupture of membranes [12]. Sonoelastography is a new sonographic technique that measures soft tissue stiffness.…”

Section: Introduction ▼mentioning

confidence: 99%

Cervical Sonoelastography and Cervical Length Measurement but not Cervicovaginal Interleukin-6 Are Predictors for Preterm Birth

Weichert

Schöning

Fischer

et al. 2016

Ultrasound International Open

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reproductive technologies and better outcomes in indicated preterm births [5]. The ability to identify women at high risk for spontaneous preterm birth is crucial yet remains difficult. In women with preterm contractions, 30 % of preterm labors resolve spontaneously, whereas 50 % of women treated for preterm labor deliver at term [6]. In addition to typical risk factors, such as low socioeconomic status, multiple pregnancies, or a history of cervical surgery, the primary methods used for the detection of preterm birth are transvaginal ultrasound and the presence of fetal fibronectin (fFN) in cervicovaginal fluid. These methods allow clinicians to perform targeted interventions such as referral to a tertiary care center, antenatal corticosteroid administration, and tocolysis. The relationship between cervical length and the incidence of preterm birth is well-known [7]. Introduction ▼Preterm birth is defined as delivery before a gestational age of 37 weeks. Annually, more than 15 million children are affected worldwide. It is the main cause of perinatal morbidity and mortality, and almost one-half of long-term neurologic morbidity cases and approximately 3-quarters of neonatal mortality are associated with preterm birth [1,2]. Furthermore, approximately one-third of neonatal deaths are caused by prematurity leading to more than 1 million newborn deaths per year [3]. Despite advancing knowledge of the risk factors and mechanisms associated with preterm labor and delivery, the preterm birth rate has risen in most industrialized countries [4]. This increase has been partially attributed to a rise in multiple pregnancies that occurred as a result of assisted Purpose: Worldwide, preterm birth annually affects more than 15 million infants. Despite increasing knowledge of the risk factors and mechanisms associated with preterm labor, the preterm birth rate has risen in most industrialized countries. The ability to identify women at high risk for spontaneous preterm birth is crucial yet remains difficult. The aim of the present study was to assess the value of cervical length measurements in combination with sonoelastography and interleukin 6 (IL-6) concentrations in cervicovaginal secretions to identify women at risk for preterm birth. Materials and Methods: 36 pregnant women with signs of threatened preterm birth were enrolled in our prospective cohort study. Cervical length measurement, sonoelastography, and IL-6 levels from cervicovaginal swab samples were measured. Results:The preterm birth rate was found to be 33.3 % in our study cohort. Maternal age did not differ between the preterm and term birth groups. Measurement of the cervical length alone was found to have a sensitivity of 0.7 and a specificity of 0.8, whereas cervical sonoelastography had a sensitivity of 0.66 and a specificity of 0.82. By using a combination of both methods, the sensitivity and specificity were found to be 0.9 and 0.7, respectively. IL-6 levels were not found to differ between women with term deliveries and women with preterm births. Conc...

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Interleukin-6 bedside testing in women at high risk of preterm birth

Cited by 4 publications

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Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Predictive value of vaginal IL-6 and TNFα bedside tests repeated until delivery for the prediction of maternal-fetal infection in cases of premature rupture of membranes

Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes

Cervical Sonoelastography and Cervical Length Measurement but not Cervicovaginal Interleukin-6 Are Predictors for Preterm Birth

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