Interleukin-6 (IL-6) Level as an Indikator of Progresivity Rheumatoid Arthritis (RA) Disease

Tania, Putu Oky Ari; Simamora, Dorta; Parmasari, Wahyuni Dyah; Rahmawati, Febtarini

doi:10.30742/jikw.v3i1.44

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, IL-6targeted treatment is effective in resolving the cytokine storm during the progression of COVID-19 infection. 14,15 The clinical manifestations of COVID-19 infection vary greatly, ranging from asymptomatic to severe or critical. Shortness of breath is one of the typical symptoms of COVID-19, which can quickly turn into a critical condition, such as acute respiratory distress.…”

Section: Discussionmentioning

confidence: 99%

“…14 Individuals who engage in regular physical activity have lower baseline IL-6 levels than sedentary individuals. 15 Similar studies suggest that pro-and antiinflammatory cytokines must be balanced for the immune system to modulate and consolidate neural network reorganization, as well as have positive or negative effects on brain neuroplasticity. 16 This can also be used as a reference for providing exercise for COVID-19 patients who are active or in the recovery period.…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Effects of Upper Arm and Breathing Exercise on Interleukin-6 in COVID-19 Patients

Tarigan,

Listyoko,

Pandia

et al. 2024

View full text Add to dashboard Cite

Introduction: COVID-19 disease has become a comprehensive world issue and has been declared a significant threat to global health. Interleukin-6 (IL-6) is an important inflammatory marker and one of the triggers of the cytokine storm in COVID-19, where increased levels can be an independent predictor of COVID-19 mortality. This study aimed to observe the effect of upper arm and breathing exercises on IL-6 levels in severe COVID-19 patients. Methods: The study design was quasi-experimental, with blood tests conducted before and after the examination. A total of 20 patients with confirmed COVID-19 were involved, divided into intervention and control groups. Results: Blood tests to determine baseline IL-6 levels were performed in all patients. Patients from the intervention group were given upper arm and breathing exercises for ten days, twice a day, via video tutorials on mobile phones, while patients from the control group did not receive any exercises. Patients from the intervention group obtained mean pre- and post-exercise IL-6 levels of 42.38 ± 48.48 and 16.78 ± 18.29, respectively (p = 0.005). Conclusion: Upper arm and breathing exercises showed significant changes in IL-6 levels in severe COVID-19 patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Effects of Upper Arm and Breathing Exercise on Interleukin-6 in COVID-19 Patients

Tarigan,

Listyoko,

Pandia

et al. 2024

View full text Add to dashboard Cite

show abstract

“…RA occurs when T lymphocytes infiltrate the joint, followed by an increase in macrophages and fibroblasts induced by cytokine shedding. Th2 activation produces a number of cytokines: interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-6 (IL-6) and interleukin-10 (IL-10) [18].…”

Section: Molecular Docking Analysis Of Phytosterol Compounds With Il-6mentioning

confidence: 99%

Virtual Prediction of Phytosterol Compounds from Pegagan (Centella asiatica L.) As Inhibitor for Interleukin-6 (IL-6) to Prevent Rheumatoid Arthritis Disease

Mawardi,

Wulandari,

Mustakim

et al. 2023

JSMARTech

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is an autoimmune disease in which the joint area is inflamed which results in swelling, pain and often causes damage to the inside of the joint. Rheumatoid Arthritis is characterized by decreased , so that Interleukin-6 (IL-6) inhibitors are needed. This strategy is convincing for controlling RA. Pegagan have to play role in overcoming the problem of joint inflammation. Phytosterols are compounds that are commonly found in pegagan and include antioxidants that are beneficial for health. This study aims to determine the mechanism pathway of pegagan's active compounds in the treatment of RA. This study used an in silico approach by analyzing target proteins and active compounds of pegagan through Lipinski rule of five and molecular docking analysis. This study used 3 phytosterol compounds including campesterol. β-sitosterol. and stigmasterol. The control used in this study was the tartaric acid compound whose receptor molecule was interleukin-6 (IL-6) with PDB ID: 1-ALU. The results of the Lipinski rule analysis found that all the test compounds used met the criteria and could be applied as drugs. Based on the results of molecular docking, stigmasterol has a good binding affinity value and is able to exceed the control compound with the highest binding affinity with score of -6.4 kcal/mol. Visualization results show that there is an interaction formed between the active compound and the target protein so that phytosterl compounds have a role that can be an alternative medicine in the prevention and treatment of RA.

show abstract

“…Interleukin-6 menentukan dampak yang signifikan terhadap ketahanan sistem pernapasan terhadap peningkatan kerja mekanik pernapasan saat inspirasi. Interleukin-6 diproduksi dibeberapa jenis sel limfoid maupun non limfoid, antara lain sel T, sel B, monosit, fibroblast, keratinosit, sel endotel, sel mesangial, dan beberapa sel tumor, artinya sitokin ini tidak spesifik untuk menunjukkan parameter penyakit tertentu 15 .…”

Section: Hasilunclassified

Hubungan Fungsi Paru dengan Kadar Interleukin-6 (Il-6) Pada Penduduk Yang Berada Di Sekitar Pabrik Karet Gandus Dan Tempat Pembuangan Akhir (Tpa) Sampah Sukawinatan Palembang

Adela¹,

Zulkarnain²,

Flora³

2019

BioJInd

View full text Add to dashboard Cite

Paparan dari polusi udara dapat mengganggu kapasitas fungsi paru dan sistem imum tubuh. Kapasitas fungsi paru merupakan penjumlahan dari dua volume paru atau lebih. Interleukin-6 (IL-6) merupakan mediator inflamasi pada patogenesis pernapasan. Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi paru dan kadar Interleukin-6 (IL-6) pada penduduk yang berada di sekitar Pabrik Karet Gandus dan TPA Sukawinatan Palembang. Rancangan penelitian yang digunakan adalah jenis korelasi atau explanatory yaitu mengkaji hubungan antara variabel. Sampel sebanyak 72 dan dibagi menjadi 2 kelompok : kelompok di wilayah Pabrik Karet Gandus dan kelompok di wilayah Tempat Pembuangan Akhir (TPA) Sampah Sukawinatan Palembang. Uji fungsi paru di ukur menggunakan spirometri dan kadar Interleukin-6 diukur menggunakan pemeriksaan ELISA. Hasil uji Chi square menunjukkan bahwa tidak terdapat hubungan yang bermakna (p value = 0,001) antara fungsi paru pada penduduk yang berada di sekitar Pabrik Karet Gandus dan TPA Sampah Sukawinatan. Dan tidak terdapat hubungan yang bermakna (p value = 0,337) antara kadar Interleukin-6 (IL-6) pada penduduk yang berada di sekitar Pabrik Karet Gandus dan TPA Sampah Sukawinatan. Hasil uji Chi Square menunjukkan bahwa tidak terdapat hubungan yang bermakna (p value = 0,626) antara fungsi paru dan kadar Interleukin-6 (IL-6) pada penduduk yang berada di sekitar Pabrik Karet Gandus. Hasil uji Chi Square menunjukkan bahwa tidak terdapat hubungan yang bermakna (p value = 1,000) antara fungsi paru dan kadar Interleukin-6 (IL-6) pada penduduk yang berada di sekitar TPA Sampah Sukawinatan Palembang. Kesimpulan dari hasil penelitian bahwa Tidak terdapat hubungan yang bermakna (p<0,05) antara kadar Interleukin-6 dan Fungsi Paru pada penduduk yang berada di sekitar Pabrik Karet Gandus dan TPA Sukawinatan Palembang.

show abstract

Interleukin-6 (IL-6) Level as an Indikator of Progresivity Rheumatoid Arthritis (RA) Disease

Cited by 4 publications

References 0 publications

Effects of Upper Arm and Breathing Exercise on Interleukin-6 in COVID-19 Patients

Effects of Upper Arm and Breathing Exercise on Interleukin-6 in COVID-19 Patients

Virtual Prediction of Phytosterol Compounds from Pegagan (Centella asiatica L.) As Inhibitor for Interleukin-6 (IL-6) to Prevent Rheumatoid Arthritis Disease

Hubungan Fungsi Paru dengan Kadar Interleukin-6 (Il-6) Pada Penduduk Yang Berada Di Sekitar Pabrik Karet Gandus Dan Tempat Pembuangan Akhir (Tpa) Sampah Sukawinatan Palembang

Contact Info

Product

Resources

About