Interleukin-6 in neutrophils from peripheral blood and inflammatory periradicular tissues

Serum interleukin-6 as a serologic marker of chronic periapical lesions: a case-control study

“…Their findings indicated that there was a dose-dependent increase in IL-6 levels when cells were stimulated with A. actinomycetecomitans and P. gingivalis extract, the response in the latter being to a lesser extent. 22 These results are compatible with the present study regarding the elevated levels of IL-6. The higher level of IL-6 in the mentioned study compared to our results could be explained by the fact that IL-6 can be produced by a variety of cells such as neutrophils.…”

“…IL-6 was also detected in neutrophils from peripheral blood and inflammatory periradicular tissues. 22 It was shown that IL-6 plays a central and complex role in regulation of the immune response. 2 An animal study has demonstrated that IL-6 is a pro-inflammatory mediator because it is produced locally and immediately, following stimulation by IL-1 and TNF-α in the inflammatory cascade.…”

“…11 On the other hand, IL-6 interferes with apoptosis in neutrophils. 22 Kawashima et al 11 observed the production of IL-6 in normal murine periapical tissues and found that it is further induced specially on day 14 after pulp exposure; however, they failed to detect IL-6 mRNA. Redics et al 7 suggested that higher local IL-6 concentrations existed in symptomatic lesions containing epithelial cells, representing an active stage of apical periodontitis, compared to asymptomatic, poor PMN cell, non-epithelialized chronic and healing lesions.…”

Levels of GM-CSF, IL-3, and IL-6 in Fluid and Tissue from Human Radicular Cysts

“…These cytokines might be acting synergistically with IL-1, promoting activation/differentiation of osteoclasts and production/secretion of prostaglandins by many cell types, including fibroblasts and osteoblasts (Caracciolo et al, 1989;Torabinejad, 1994). Our results demonstrating the presence of IL-6 in the vast majority of the fluid and tissue samples are in agreement with those of previous studies (Bando et al, 1993;Formigli et al, 1995;Meghji et al, 1996;Euler et al, 1998;Honma et al, 1998). It has been reported that cystic growth may be due to the autocrine stimulation of cyst epithelial cell proliferation by IL-1 and IL-6, and the osteolytic activity of these cytokines, causing local bone loss (Bando e t a l .…”

Can Apical Periodontitis Modify Systemic Levels of Inflammatory Markers? A Systematic Review and Meta-analysis

“…Takahashi et al (1997) (69) Periradicular tissue samples were evaluated instead of serum levels of IMs. Euler et al (1998) (106) Cytokine production by neutrophils from periradicular tissue samples were evaluated instead of serum levels of IM. Matsushita et al (1999) (107) The study evaluated the induction of cytokines by lipopolysaccharides from species of endodontopathic black-pigmented bacteria instead of serum levels of IMs.…”