Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

Quintanilla, Rodrigo A.; Orellana, Daniel; González-Billault, Christian; Maccioni, Ricardo B.

doi:10.1016/j.yexcr.2004.01.002

Cited by 371 publications

(247 citation statements)

References 59 publications

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“…Similar findings have been reported for IL6, recently shown to directly modulate Tau phosphorylation via the cdk5/p35 pathway in hippocampal neurons (Quintanilla et al, 2004). TNFα has also been shown to directly induce the production of Aβ peptides in vitro (Yamamoto et al, 2007) and mediate amyloid-induced toxicity both in vitro and in vivo (Li et al, 2004;Medeiros et al, 2007).…”

Section: Reelin-mediated Signaling In Normal and Pathological Aging: supporting

confidence: 81%

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Knuesel

2010

Progress in Neurobiology

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Section: Reelin-mediated Signaling In Normal and Pathological Aging: supporting

confidence: 81%

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Knuesel

2010

Progress in Neurobiology

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“…Thus, the chronic increase in pro-inflammatory cytokines in the AD brain [134,135] could induce sustained inflammatory-toxicity, causing neuronal dysfunction and ultimately the deterioration observed in AD progression. Furthermore, as noted above, cytokines can also influence AD-related pathology, including Ab and tau [67,79,136,137]. Moreover, indoleamine 2, 3-dioxygenase, which is activated by cytokines, may be an additional candidate mechanism of cytokineinduced AD pathology and could lead to increased levels of the neurotoxic factor, quinolinic acid [138], and promote tau hyperphosphorylation [139].…”

Section: Discussionmentioning

confidence: 94%

“…An in vitro study suggested that overexpressed IL-6 influences the cdk5/p53 pathway to induce the phosphorylation of tau, increasing the AD risk [67]. Regarding genetic polymorphisms of the IL-6 gene, the protective role of IL-6 -174 in AD development has been highlighted [68,69].…”

Section: Il-6mentioning

confidence: 99%

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

2016

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Neuroinflammatory processes are a central feature of Alzheimer's disease (AD) in which microglia are over-activated, resulting in the increased production of proinflammatory cytokines. Moreover, deficiencies in the antiinflammatory system may also contribute to neuroinflammation. Recently, advanced methods for the analysis of genetic polymorphisms have further supported the relationship between neuroinflammatory factors and AD risk because a series of polymorphisms in inflammation-related genes have been shown to be associated with AD. In this review, we summarize the polymorphisms of both pro-and anti-inflammatory cytokines related to AD, primarily interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha, IL-4, IL-10, and transforming growth factor beta, as well as their functional activity in AD pathology. Exploration of the relationship between inflammatory cytokine polymorphisms and AD risk may facilitate our understanding of AD pathogenesis and contribute to improved treatment strategies.

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“…13 MTT reagents from Sigma and the procedure were carried out as described in previous work. 19 Both Pluronic and culture media were sterilized by filtration through filters of 0.2 lm. An appropriate amount of antibiotics were added to culture medium.…”

Section: Determination Of Cell Viabilitymentioning

confidence: 99%

Effects of pluronic F68 micellization on the viability of neuronal cells in culture

Samith

Mino

Ramos-Moore

et al. 2013

J of Applied Polymer Sci

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Triblock copolymers with surface-active properties, referred to as Pluronic, have shown potential medical applications such as drug delivery to selective targets in the human body. In particular, the transport of anti-inflammatory substances to the brain is required for illness treatment, thus the study of delivery agents that cross the blood-brain barrier is relevant. In this article we study the effects of the micelle formation on the morphologic and cytotoxic properties of Pluronic F68. We determinate the critical micellar concentration (CMC) by standard tensiometric and absorbance measurements, and also we analyze the morphology of polymers by atomic force microscopy. Our observations indicate that the morphological properties of F68 are drastically modified in the CMC range, as well as the ability to increase the viability of neuroblastoma cells maintained under culture conditions, as compared with nontreated cells. Our conclusions highlight the close correlation between morphological and physiochemical properties of Pluronic, which must be further understood in order to achieve highly controlled pharmacological uses.

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Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

Cited by 371 publications

References 59 publications

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

Effects of pluronic F68 micellization on the viability of neuronal cells in culture

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