Interleukin 6 induces the hair follicle growth phase (anagen)

Tanabe, Atsuko; Ogawa, Yutaka; Takemoto, Takashi; Wang, Yibiao; Furukawa, Takako; Kono, Hirao; Adachi, Yasushi; Kusumoto, Kenji

doi:10.1016/j.jdermsci.2006.04.004

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…Our data are also in agreement with the recent report by Hamada and Randall (2006), who found that conditioned medium of human balding DP cells delay the onset of anagen in mice. However, our finding differs with the recent report from Tanabe et al (2006) who found a hair growth-promoting effect of IL-6. Although further investigation is needed, we suggest that the discrepancy might be due to the doses of IL-6 used.…”

Section: Discussioncontrasting

confidence: 99%

Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

Kwack

Ahn²,

Kim

et al. 2012

Journal of Investigative Dermatology

129

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Autocrine and paracrine factors are produced by balding dermal papilla (DP) cells following dihydrotestosterone (DHT)-driven alterations and are believed to be key factors involved in male pattern baldness. Herein we report that the IL-6 is upregulated in balding DP cells compared with non-balding DP cells. IL-6 was upregulated 3 hours after 10-100 nM DHT treatment, and ELISA showed that IL-6 was secreted from balding DP cells in response to DHT. IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) were expressed in follicular keratinocytes, including matrix cells. Recombinant human IL-6 (rhIL-6) inhibited hair shaft elongation and suppressed proliferation of matrix cells in cultured human hair follicles. Moreover, rhIL-6 injection into the hypodermis of mice during anagen caused premature onset of catagen. Taken together, our data strongly suggest that DHT-inducible IL-6 inhibits hair growth as a paracrine mediator from the DP.

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Section: Discussioncontrasting

confidence: 99%

Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

Kwack

Ahn²,

Kim

et al. 2012

Journal of Investigative Dermatology

129

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“…In addition to pigmented hairs, numerous small non-pigmented hair follicles and hair pegs were also observed. While punctate ALP staining patterns were only observed in grafted ESS with mDPC-GFP, high ALP activity was detected along the wound edges of both ESS with mDPC-GFP and ESS controls, in agreement with a previous report indicating the promotion of host animals’ hairs along the wound edge following skin transplantation [13]. Induction of anagen hairs in host animals as well as the more advanced stage of neofollicles adjacent to the wound edge suggests the plausible involvement of the wound-induced environment and hair growth.…”

Section: Discussionsupporting

confidence: 92%

Characterization of Hair Follicle Development in Engineered Skin Substitutes

et al. 2013

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Generation of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured postnatal cells. To investigate the feasibility and the limitation of hair regeneration, engineered skin substitutes were prepared with chimeric populations of cultured human keratinocytes from neonatal foreskins and cultured murine dermal papilla cells from adult GFP transgenic mice and grafted orthotopically to full-thickness wounds on athymic mice. Non-cultured dissociated neonatal murine-only skin cells, or cultured human-only skin keratinocytes and fibroblasts without dermal papilla cells served as positive and negative controls respectively. In this study, neonatal murine-only skin substitutes formed external hairs and sebaceous glands, chimeric skin substitutes formed pigmented hairs without sebaceous glands, and human-only skin substitutes formed no follicles or glands. Although chimeric hair cannot erupt readily, removal of upper skin layer exposed keratinized hair shafts at the skin surface. Development of incomplete pilosebaceous units in chimeric hair corresponded with upregulation of hair-related genes, LEF1 and WNT10B, and downregulation of a marker of sebaceous glands, Steroyl-CoA desaturase. Transepidermal water loss was normal in all conditions. This study demonstrated that while sebaceous glands may be involved in hair eruption, they are not required for hair development in engineered skin substitutes.

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“…Recombinant mouse IL-6 (rmIL-6, Biomyx, San Diego, CA) and IL-17 (rmIL-17, R & D Systems, Minneapolis, MN) were reconstituted in sterile Dulbecco’s PBS (Invitrogen) and administered subcutaneously at doses of 4 μg/mouse/day or 0.5 μg/mouse/day, respectively, in a total volume of 100 μL PBS (31, 32). Vehicle-treated controls received 100 μl of PBS alone.…”

Section: Methodsmentioning

confidence: 99%

Cyclooxygenase-1 Orchestrates Germinal Center Formation and Antibody Class-Switch via Regulation of IL-17

Blaho¹,

Buczynski²,

Dennis

et al. 2009

The Journal of Immunology

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The cyclooxygenase (COX) enzymes are known modulators of innate immune cell function; however, their contributions to adaptive immunity are relatively unknown. We investigated the roles of COX-1 and COX-2 in the humoral immune response to infection with the Lyme disease pathogen Borrelia burgdorferi. We report that in vitro, murine B cells constitutively expressed COX-1 and up-regulated expression of both COX-1 and COX-2 as well as their products PGE2, PGF2α, and thromboxane B2 and their receptors following stimulation with B. burgdorferi or anti-CD40. In vitro inhibition of COX-1 and/or COX-2 in murine B cells resulted in decreased eicosanoid production and altered Ab production. Importantly, infection of mice lacking COX-1, but not COX-2, activity resulted in a defect in Ig class-switching and a lack of Borrelia-specific IgG production. This defect correlated with decreased germinal center formation and IL-6 and IL-17 production, and it could be partially recovered by restoration of IL-6, but fully recovered by IL-17. Furthermore, sera from COX-1 inhibitor-treated mice were dramatically less effective in killing B. burgdorferi, but borreliacidal activity was restored in COX-1 inhibitor-treated mice administered IL-17. We conclude that IL-17 plays a role in Ab production and Ig class-switching in response to infection and that COX-1 is a critical, previously unrecognized regulator of this response.

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Interleukin 6 induces the hair follicle growth phase (anagen)

Cited by 11 publications

References 4 publications

Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

Characterization of Hair Follicle Development in Engineered Skin Substitutes

Cyclooxygenase-1 Orchestrates Germinal Center Formation and Antibody Class-Switch via Regulation of IL-17

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