Interleukin-6 promotor gene polymorphisms and susceptibility to chronic hepatitis B virus in Egyptians

El-maadawy, Eman A.; Talaat, Roba M.; Ahmed, Maha M.; El-Shenawy, Soha Z.

doi:10.1016/j.humimm.2018.12.009

Cited by 16 publications

(22 citation statements)

References 44 publications

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“…A direct positive correlation was also detected between HBV and the presence of GC genotype and C allele. [13] Riazalhosseini et al also observed the frequency of allele G of rs1800796 was higher among healthy controls than that among chronic HBV patients (0.303 vs 0.258) and GC+CC genotype was associated with a protection mechanism against HBV infection (OR = 0.40, 95% CI: 0.34-0.48). [14] However, inconsistent conclusions were also reported, with no significant associations of rs1800796 polymorphism with HBV infection, [15] hepatitis C virus (HCV) infection, [16] LC and HCC.…”

Section: Introductionmentioning

confidence: 92%

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Wang

Yan

2019

Medicine

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Background: Several studies have explored the associations between interleukin-6 (IL-6) gene polymorphisms and the susceptibility to liver diseases, however, results remain ambiguous. The goal of this study was to conduct a meta-analysis to provide more credible evidence.Methods: Studies identified in the PubMed, Cochrane Library, and EMBASE databases were used to perform a meta-analysis via the STATA software. Pooled odds ratios (OR) were calculated under fixedand random-effects models to estimate the potential genetic associations.Results: Twenty-five case-control studies involving 5813 cases and 5298 controls were included in this meta-analysis. Overall, the pooled results suggested that rs1800795 polymorphism was significantly associated with the risk of liver diseases in heterozygote (GC vs CC; OR = 1.57) and dominant (GG+GC vs CC: OR = 1.47) models; rs1800796 polymorphism was significantly associated with the susceptibility to liver diseases in heterozygote (GG vs GC; OR = 0.58) and recessive (GG vs GC+CC: OR = 0.68) models; rs1800797 polymorphism was significantly associated with genetic predisposition to liver diseases in homozygote (GG vs AA: OR = 1.63), heterozygote (GA vs AA; OR = 1.53) and dominant (GG + GA vs AA: OR = 1.61) models. A similar conclusion was found in the HBV, HCV, HCC, NASH and alcoholic liver disease of all ethnic populations for rs1800795; HBV and Asian subgroups for rs1800796; HCV and non-Asian subgroups for rs1800797. However, IL-6 rs2069837 and rs2066992 polymorphisms did not exhibit significant associations with the risk of liver diseases under any genetic models. Conclusion:This meta-analysis suggests that patients carrying G (rs1800795), C (rs1800796) or G (rs1800797) allele or genotypes of IL-6 may be more likely to suffer from liver diseases, which was ethnic-dependent.Abbreviations: CI = confidence interval, HBV = hepatitis B virus, HC = healthy, HCC = hepatocellular carcinoma, HCV = hepatitis C virus, HIV = human immunodeficiency virus-type 1, IF = infection resolved, IL-6 = interleukin-6, LC = liver cirrhosis, NASH = nonalcoholic steatohepatitis, NOS = New-castle-Ottawa Scale, OR = odds ratio, PRISMA = Preferred Reporting Items for Systematic Review and Meta-analysis, SNP = single nucleotide polymorphism, STAT3 = signal transducer and activator of transcription 3.

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Section: Introductionmentioning

confidence: 92%

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Wang

Yan

2019

Medicine

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“…On the contrary, genotyping of eight SNPs in the IL6 gene (rs1524107, rs1800795, rs1800797, rs2069827, rs2069830, rs2069837, rs2069840, and rs2069845) revealed that they were not related to the occurrence and short‐term prognosis of HBV‐associated acute‐on‐chronic liver failure in Chinese patients 37 . However, El‐Maadawy et al have also investigated the association between HBV risk and three SNPs of the IL6 gene (−174G/C, −572G/C, and −597G/A) in terms of haplotypes 21 . Their results depicted that G‐C‐A haplotype showed a significantly decreased frequency in chronic patients with HCV, whereas G‐G‐A was observed to be significantly elevated.…”

Section: Discussionmentioning

confidence: 99%

“…However, the serum level and gene expression of IL‐6 have also been correlated with variants mapped to the promoter region of the gene. For instance, IL6 −174 (rs1800795) G allele and GG genotype have been associated with the downregulation of the IL6 gene as compared with CC genotype 21 . Thus, a collective evaluation of the serum level, gene expression, and SNPs of IL‐6 in viral hepatitis is a fruitful approach to understand the role of IL‐6 in etiology and pathogenesis of HBV or HCV infection, especially if these results are correlated with immunological and clinical profiles of the infections, for instance, inflammation, fibrosis, and hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients

Al-Saffar

Ad’hiah

2020

Journal of Medical Virology

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Hepatitis B and C viruses (HBV and HCV) are common causative pathogens of viral hepatitis. Progression of both infections is determined by virus‐ and host‐related factors. Cytokines are important host genetic factors that may have a predisposing role in HBV and HCV infections. This case‐control study evaluated the genetic association of IL4RA+1902 (rs1801275), IL6−174 (rs1800795), IL6−597 (rs1800797), and IL12B−1188 (rs3212227) variants with chronic HBV and HCV infections among Iraqi patients. A total of 220 viral hepatitis patients were enrolled in the study (113 HBV and 107 HCV), together with 141 healthy subjects. Sequence‐specific primer polymerase chain reaction assay was the genotyping method. Results revealed that under a dominant genetic model, IL6−174 variant was significantly associated with HBV infection, whereas no association with the HCV risk was reported. However, the risk for both infections was markedly associated with IL6−597 variant under recessive, dominant, and codominant genetic models. Estimation of IL6−174‐IL6−597 haplotypes depicted that G‐A haplotype was significantly associated with an increased risk to develop HBV infection, whereas a significantly decreased risk was associated with G‐G and C‐G haplotypes. For HCV, G‐G and C‐A haplotypes were significantly associated with risk of HCV infection. IL4RA+1902 and IL12B−1188 variants showed no association with HBV or HCV risk. Analysis of variance revealed no significant association between genotypes of the four determined single‐nucleotide polymorphisms and HBV or HCV viral load. In conclusion, the study supports the concept that IL6−597 variant is associated with susceptibility to HBV and HCV infections among Iraqis. The risk of HBV infection is further associated with IL6−174 variant.

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“…The role of IL-6 gene polymorphisms was also considered to be associated with susceptibility to hepatitis in a previous study. 40 IL-1 family member 10, which was recently renamed IL-38, exerts anti-inflammatory effects by effectively inhibiting inflammatory mediator production (IL-17A and IL-22). 41 , 42 Afzal et al.…”

Section: Methodsmentioning

confidence: 99%

Pathogenesis of liver injury in Takayasu arteritis: advanced understanding leads to new horizons

Kang

Sun

et al. 2020

J Int Med Res

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Liver injury in Takayasu arteritis (TA) is a rare phenomenon. Most symptoms are nonspecific, and the exact pathogenesis remains to be elucidated. Early diagnosis and new treatment methods are important for an improved prognosis. A summary of the clinical information and mechanistic analyses may contribute to making an early diagnosis and development of new treatment methods. A PubMed search was conducted using the specific key words “Takayasu arteritis” and “liver” or “hepatitis” or “hepatic”. Symptoms and treatment of TA with an accompanying liver injury were reviewed retrospectively. Many factors are presumed to be involved in the mechanism of TA with liver injury, including the immune response, genes, infections, and gut microbiota. There are several lines of evidence indicating that immune dysfunction is the main pathogenic factor that triggers granuloma formation in TA patients. However, the role of genetics and infections has not been fully confirmed. Recently, the gut microbiota has emerged as an essential component in the process. We reviewed in detail the current concepts that support the complex pathogenesis of TA accompanied by liver injury, and we presented recent theories from the literature. Finally, we discussed future research directions of liver injury in TA.

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Interleukin-6 promotor gene polymorphisms and susceptibility to chronic hepatitis B virus in Egyptians

Cited by 16 publications

References 44 publications

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Interleukin-6 gene polymorphisms and susceptibility to liver diseases

Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients

Pathogenesis of liver injury in Takayasu arteritis: advanced understanding leads to new horizons

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