Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection

Martino, Maurizio de; Galli, Luisa; Chiarelli, Francesco; Verrotti, Alberto; Rossi, Maria Elisabetta; Bindi, Giuseppe; Galluzzi, F.; Salti, R; Vierucci, A

doi:10.1006/clim.2000.4838

Cited by 38 publications

(33 citation statements)

References 33 publications

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“…IGF-I and IL-6 was found in the present study. In previous studies, IL-6 has been postulated to inhibit the secretion of IGF-I (Lazarus et al, 1993;de Martino et al, 2000). However, a recent study by Barbieri et al (2003).…”

Section: Discussionmentioning

confidence: 95%

“…In adult ESRD patients, reduced IGF-I activity has been postulated to be an important mediator of growth hormone (GH) resistance (Powell et al, 1996) influenced by residual renal function, likely because of a decreased clearance of binding proteins that have a predominantly inhibitory effect on IGF-I signaling (Powell et al, 1996). Furthermore, several studies have shown a link between inflammation and IGF-I activity (Lazarus et al, 1993;de Martino et al, 2000), which is decreased in inflamed individuals. The activity of IGF-I is also determined by its many binding proteins, the two most prominent being IGFBP-1 and IGFBP-3 (Brismar et al, 1994;Iglesias et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease?

et al. 2006

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Introduction: Malnutrition is common in end-stage renal disease (ESRD) and affects both morbidity and mortality. The growth hormone-dependent insulin-like growth factor (IGF)-I may be a good marker of malnutrition because of its short half-life. In the present study, we investigate the influence of decreasing residual renal function as well as of chronic inflammation on the IGF system to assess its usefulness in this patient group. Patients and methods: Cross-sectional analysis of 220 ESRD patients (140 males) with a mean age of 5271 years. Biochemical analyses of insulin, IGF-I, IGFBP-1, IGFBP-3, IL-6, high sensitivity (hs)-CRP and other routine markers. Malnutrition status was recorded using subjective global assessment (SGA), body mass index, estimated protein intake from nitrogen appearance (nPNA), handgrip strength (HGS) and insulin resistance (HOMA-IR). Dual energy X-ray absorptiometry was used to assess body composition. Results: Both IGF-I and IGFBP-1 showed significant and opposite correlations with most markers of nutritional status, including SGA (r ¼ À0.29 and 0.27; Po0.001), nPNA (r ¼ 0.18 and À0.22; Po0.05), S-creatinine (r ¼ 0.19 and À0.19; Po0.01) and HGS (r ¼ 0.21 and À0.25; Po0.01). IFG-I was strongly correlated with IGFBP-3 (r ¼ 0.62; Po0.001) and inversely correlated with IGFBP-1 (r ¼ 0.44; Po0.001). Both IGF-I and IGFBP-3, but not IGFBP-1, were significantly correlated with age (r ¼ À0.25 for IGF-I and À0.35 for IGFBP-3; Po0.001) and hsCRP (r ¼ À0.21 and À0.32; Po0.01). In multivariate analysis, SGA and s-albumin were independent predictors of both IGF-I and IGFBP-1. Conclusion: Both IGF-I and IGFBP-1 appear to correlate well with markers of protein-energy malnutrition and sarcopenia. However, IGF-I is also influenced by age, whereas IGFBP-1 is influenced by glucose metabolism. IGFBP-3 does not correlate with nutritional status in ESRD, perhaps because of a strong association with inflammation.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease?

et al. 2006

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“…We found that in patients with s-JIA levels of intact IGFBP-3 were inversely correlated with serum IL-6 levels and with clinical and laboratory parameters of disease activity. A direct relationship between increased IL-6 and reduced IGFBP-3 is also suggested by 1) the close relation of a rapid fall in IL-6 and CRP levels with a significant increase in IGFBP-3 levels following elementary diet in Crohn's disease (31,33); and 2) the correlation between IL-6 production and decreased levels of IGF-I and IGFBP-3 in HIV-infected children with decreased height velocity (34,35). All together, these clinical observations, as well as our results in mice, strongly suggest that the chronic overproduction of IL-6 is responsible for the decrease in circulating IGFBP-3 in chronic inflammation/infection in childhood.…”

Section: Discussionmentioning

confidence: 96%

Effect of IL-6 on IGF Binding Protein-3: A Study in IL-6 Transgenic Mice and in Patients with Systemic Juvenile Idiopathic Arthritis

Benedetti¹,

Meazza²,

Oliveri³

et al. 2001

Endocrinology

127

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Stunted growth is a common complication of childhood diseases characterized by chronic inflammation or infections.We previously demonstrated that NSE/hIL-6 transgenic mice, overexpressing the inflammatory cytokine IL-6 since early phase of life, showed a marked growth defect associated with decreased IGF-I levels, suggesting that IL-6 is one of the factors involved in stunted growth complicating chronic inflammation in childhood. Here we show that NSE/hIL-6 mice have normal liver IGF-I production, decreased levels of IGF bind-

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“…Interestingly, previous studies (12,21) demonstrated that IL-6 inhibits the secretion of IGF-I and its biological activity and that IL-6 overproduction is a mechanism implicated in IGF-I and insulin-like growth factor-binding protein (IGFBP)-3 downregulation (21). Furthermore, in transgenic mice, an IGF-I deficiency caused by IL-6-related mechanisms determined growth impairment (11).…”

mentioning

confidence: 99%

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

Barbieri

Ferrucci

Ragno

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

271

194

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Deregulation of the inflammatory response plays a major role in the age-related decline of physical performance. The causal pathway leading from inflammation to disability has not been fully clarified, but several researches suggest that interleukin-6 (IL-6) causes a reduction of physical performance in elderly through its effect on muscle function. In vitro studies demonstrated that IL-6 inhibits the secretion of insulin-like growth factor I (IGF-I) and its biological activity, suggesting that the negative effect of IL-6 on muscle function might be mediated through IGF-I. We evaluated the joint effect of IGF-I and IL-6 on muscle function in a population-based sample of 526 persons with a wide age range (20–102 yr). After adjusting for potential confounders, such as age, sex, body mass index, IL-6 receptor, and IL-6 promoter polymorphism, IL-6, IGF-I, and their interaction were significant predictors of handgrip and muscle power. In analyses stratified by IL-6 tertiles, IGF-I was an independent predictor of muscle function only in subjects in the lowest IL-6 tertile, suggesting that the effect of IGF-I on muscle function depends on IL-6 levels. This mechanism may explain why IL-6 is a strong risk factor for disability.

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Interleukin-6 Release by Cultured Peripheral Blood Mononuclear Cells Inversely Correlates with Height Velocity, Bone Age, Insulin-like Growth Factor-I, and Insulin-like Growth Factor Binding Protein-3 Serum Levels in Children with Perinatal HIV-1 Infection

Cited by 38 publications

References 33 publications

Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease?

Are insulin-like growth factor and its binding proteins 1 and 3 clinically useful as markers of malnutrition, sarcopenia and inflammation in end-stage renal disease?

Effect of IL-6 on IGF Binding Protein-3: A Study in IL-6 Transgenic Mice and in Patients with Systemic Juvenile Idiopathic Arthritis

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

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