2012
DOI: 10.1074/jbc.m111.316869
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Interleukin 6 Signaling Regulates Promyelocytic Leukemia Protein Gene Expression in Human Normal and Cancer Cells

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Cited by 38 publications
(35 citation statements)
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“…In a randomized control trial in patients with acute myocardial infarction, a short duration of treatment with vitamin D has significant impact on weakening the rise of CRP and IL-6 (but not TNF-α) [46]. IL-6 is a multi-potential inflammatory cytokine that has a fundamental role in host defence including the immune responses, acute phase reactions and haematopoiesis [47]. Our analysis presented a positive association between vitamin D supplementation and circulating IL-6 levels.…”
Section: Discussionmentioning
confidence: 73%
“…In a randomized control trial in patients with acute myocardial infarction, a short duration of treatment with vitamin D has significant impact on weakening the rise of CRP and IL-6 (but not TNF-α) [46]. IL-6 is a multi-potential inflammatory cytokine that has a fundamental role in host defence including the immune responses, acute phase reactions and haematopoiesis [47]. Our analysis presented a positive association between vitamin D supplementation and circulating IL-6 levels.…”
Section: Discussionmentioning
confidence: 73%
“…5E, left), it has been reported that STAT3 can bind to the IRSE of the PML promoter and activate its transcription. 46 We also showed that knockdown of EGFR decreased STAT3 expression, although the underlying mechanism remains unclear (Fig. 5E, left).…”
Section: Discussionmentioning
confidence: 86%
“…However, there are also studies, which demonstrate the growth-inhibitory role of IL6, in particular, during early stages of cancer progression in melanoma, prostate, and breast cancer (22,23). To investigate whether IL6 is associated with an increase in DCIS mammosphere efficiency in response to EþP, primary human DCIS cells collected from patient biopsies were cultured under nonadherent conditions with vehicle control or estradiol (10 nmol/L; E) and progesterone (100 nmol/L; P).…”
Section: Resultsmentioning
confidence: 99%
“…PML is critical for the formation and stability of PML nuclear bodies (PML-NB), macromolecular subnuclear structures implicated in tumorsuppressing functions including apoptosis, growth arrest, and cellular senescence (29). Recently, it has been shown that IL6 signaling represents an important regulator of PML nuclear expression (23). In this study, NEMO-KD was associated with downregulation in NFkB activity, suppression in IL6 and phospho-STAT3 expression, and a decrease in PML mRNA and protein levels (23).…”
Section: Com Cells In Vitro (Data Not Shown)mentioning
confidence: 99%