Interleukin-6, vitamin D & diabetes risk-factors modified by a short-term yoga-based lifestyle intervention in overweight/obese individuals

Abstract

Background & objectives:Several diabetes prevention programmes have demonstrated a reduction in incidence of diabetes in individuals with prediabetes through weight loss. Short-term yoga-based lifestyle intervention programmes have also been shown to be efficacious in weight loss. This study was undertaken to investigate if interleukin (IL)-6, vitamin D, neopterin, vaspin, and diabetes risk factors can be modified by a short-term yoga-based lifestyle intervention in overweight/obese subjects.Methods:In this pilot study, 34 overweight/obese [body mass index (BMI) ≥23 to <35 kg/m2 per Asian cut-off values] individuals were enrolled, and received directly supervised intervention for 10 days. Thereafter, they were advised to follow this yoga-based lifestyle at home for one month, and were reassessed for study variables at day 30.Results:There was a reduction from baseline to day 10 in weight (P<0.001), BMI (P<0.001), waist/hip-ratio (P<0.05), blood glucose (P<0.01), and a significant improvement in lipid profile. There was a decrease in median fasting insulin (P<0.05), homeostatic model assessment-insulin resistance (P<0.01), and IL-6 (P<0.05). A non-significant increase in 25-OH-vitamin D, and a decrease in neopterin and vaspin were observed. Twenty subjects returned for follow up assessments. At day 30, weight loss was sustained while systolic blood pressure also showed reduction (P<0.05). Changes in vitamin D levels were significantly and negatively correlated with changes in weight, BMI and fasting blood glucose, and positively with change in high density lipoprotein. Changes in body weight and BMI significantly and positively correlated with insulin. Changes in IL-6 levels positively and significantly correlated with change in neopterin levels.Interpretation & conclusions:The findings showed that IL-6, vitamin D, and diabetes risk factors were favourably modified by a short-term yoga-based lifestyle intervention in obesity. This study also highlighted the challenges in compliance associated with the follow up of subjects following an aggressive supervised intervention of 10 days.

Effect of yoga on adipokine levels among overweight and obese people: A systematic review

“…All the six studies [ 29 , 32 , 34 , [36] , [37] , [38] ] reported a significant decrease in IL-6 levels, three studies [ 29 , 34 , 36 ] reported a significant reduction in TNF-alpha levels, and one study [ 32 ]reported an insignificant increase in TNF-alpha after 12-week yoga intervention. One study [ 39 ] reported a nonsignificant decrease in vaspin levels, one study [ 31 ] reported a significant reduction in chemerin, PAI-1, and visfatin levels, and one study reported a significant decrease in TGF-beta levels [ 34 ] following the yoga practice. [ Table 4 ].…”

Yoga For Metabolic Syndrome: A Comprehensive Review

“…Based on these findings, the authors concluded that a short-term yoga-based lifestyle intervention favorably modified IL-6, vitamin D, and diabetes risk factors in obesity. 24 Finally, a study by Kanaya et al tested a restorative yoga intervention with active stretching for metabolic outcomes. For this purpose, the authors conducted a 48-week randomized trial comparing restorative Yoga and stretching among underactive adults with metabolic syndrome at the Universities of California, San Francisco, and San Diego.…”

The effectiveness of yoga to prevent diabetes mellitus type 2

“…Several studies in the prediabetic population show the effectiveness of yoga in reducing the risk of progression to diabetic state. [33–36] There is not a single review to show the benefits of yoga in prediabetes. This will be the 1st systematic review that will show evidence that yoga significantly affects the prediabetic state and will summarize the results of these available studies.…”