Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis

Deng, Chao; Tang, Ting-Xuan; Deng, Hai; Yang, Xun; Tang, Zhaohui

doi:10.3389/fimmu.2021.747324

Cited by 115 publications

(84 citation statements)

References 106 publications

(124 reference statements)

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“…They are activated to become robust producers of IL-12 and are excellent cross-presentation cells. cDC2s are also major producers of IL-23, IL-1, TNF-α, IL-8, and IL-10 ( 39 , 95 – 97 ). pDCs (which were identified first in peripheral blood and tonsils) “sense” and respond to viral infection through rapid production of IFN-I ( 39 , 98 , 99 ).…”

Section: Depletion and Dysfunction Of Dcs In Covid-19mentioning

confidence: 99%

“…Supplementation of IFN in the early stage of SARS-CoV-2 infection is beneficial to patients. IFN-β combined with lopinavir and ribavirin can improve physical status ( 131 ) and alter the production of proinflammatory cytokines in the latter stages of COVID-19 ( 97 , 132 ). There is growing recognition that inappropriate, excessive, and mistimed IFN treatments are deleterious in viral infections ( 131 , 133 ).…”

Section: Depletion and Dysfunction Of Dcs In Covid-19mentioning

confidence: 99%

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Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

et al. 2022

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Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) “bridge” innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2: pyroptosis-induced activation; activation of the renin–angiotensin–aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection.

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Section: Depletion and Dysfunction Of Dcs In Covid-19mentioning

confidence: 99%

Section: Depletion and Dysfunction Of Dcs In Covid-19mentioning

confidence: 99%

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

et al. 2022

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“…A recent study discovered that Interleukin-7 (IL-7) signaling promotes Foxo1-Tcf1-Id3 pathways to maintain memory CD8 T cell differentiation, survival, and function ( 78 ). Although IL-7 signaling is well-established to play an important role in T cell survival and proliferation ( 79 , 80 ), before this finding, it was primarily believed to function by enhancing the expression of anti-apoptotic Bcl-2 family of proteins, especially Mcl1 and Bcl-2 ( 81 ). In another study, Han et al.…”

Section: Endogenous Factors and Cell-extrinsic Signaling Pathways Imp...mentioning

confidence: 99%

Signaling networks controlling ID and E protein activity in T cell differentiation and function

Hwang

Im²,

Rudra³

2022

Front. Immunol.

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E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental processes and effector activities in T cells. Recent findings indicate that E and ID proteins are not only responsible for regulating thymic T cell development but also modulate the differentiation, function, and fate of peripheral T cells in multiple immune compartments. Based on the well-established E and ID protein axis (E-ID axis), it has been recognized that ID proteins interfere with the dimerization of E proteins, thus restricting their transcriptional activities. Given this close molecular relationship, the extent of expression or stability of these two protein families can dynamically affect the expression of specific target genes involved in multiple aspects of T cell biology. Therefore, it is essential to understand the endogenous proteins or extrinsic signaling pathways that can influence the dynamics of the E-ID axis in a cell-specific and context-dependent manner. Here, we provide an overview of E and ID proteins and the functional outcomes of the E-ID axis in the activation and function of multiple peripheral T cell subsets, including effector and memory T cell populations. Further, we review the mechanisms by which endogenous proteins and signaling pathways alter the E-ID axis in various T cell subsets influencing T cell function and fate at steady-state and in pathological settings. A comprehensive understanding of the functions of E and ID proteins in T cell biology can be instrumental in T cell-specific targeting of the E-ID axis to develop novel therapeutic modalities in the context of autoimmunity and cancer.

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“…IL-7 -это лимфопоэтиче-ский фактор роста, который относится к короткоцепочечным цитокинам 1-го типа семейства гематопоэтина. IL-7 занимает особое положение среди других цитокинов из-за его уникальной функции в гематопоэзе, не дублирующейся другими факторами [9]. Поскольку IL-7 вовлечен в отторжение аллотрансплантата [32], снижение его концентрации в данном случае может быть благоприятным фактором.…”

Section: Discussionunclassified

Effect of short PSG peptide fragments on the cytokine profile in Wistar rats during allogeneic transplantation <i>in vivo</i>

et al. 2022

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Pregnancy-specific beta-1-glycoprotein (PSG) is a protein with pleiotropic biological effects, particularly immunoregulatory and immunosuppressive potential. The use of recombinant PSG may exert therapeutic effects in experimental animals with induced autoimmune diseases. Recently, a search for the biological effects of short linear motifs (SLiMs) has become a new strategy for designing the pharmacological compounds. Tetrapeptide regions have been identified in the primary structure of several PSGs: YQCE, YECE and YACS, these SLiMs exhibit immunomodulatory activity. The aim of our study was to evaluate the prospectives for usage of PSG peptide fragments as pharmacological agents to modulate transplant immunity. We used an original model of host-versus-graft response in male Wistar rats transplanted with bone marrow, without prior conditioning treatment of recipients. We used a cocktail of the PSG peptide fragments administered to Wistar rats in the course of allogeneic bone marrow transplantation (BM) in dynamic manner, evaluating the cytokine profile as an integral index of immune response. Cytokine levels were determined by multiplex method using Bio-Plex ProTM Rat 23-Plex kit. Statistical processing of the data was performed by means of two-way analysis of variance and Tukey’s post hoc test for multiple comparisons. We have found that the levels of pro-inflammatory cytokines (IFNγ, IL-1α, IL-1β, IL-18), as well as the contents of G-CSF, GM-CSF and IL-7 were increased in the animals injected with BM only. In the group of animals injected with BM + PSG peptides, an increase in IFNγ, IL-6, TNFα was observed, which decreased by the end of the experiment. Increased levels of antiinflammatory cytokines IL-4 and IL-13 were detected in blood serum of the animals on day +14. Moreover, administration of PSG peptides also led to increase in IL-2, M-CSF, MCP-1, and RANTES levels on day 14 from the beginning of the experiment, and to a gradual decrease in their levels till the end of the experiment. Meanwhile, control group showed a marked tendency for increase of these and other cytokines. Thus, it was shown that the use of PSG peptides upon development of immune response to BM allograft may promote a return to normal levels for the most cytokines studied, thus presuming the immunopharmacological potential of these peptides. The obtained data can be used to develop a pharmacological preparation of the studied peptides to correct the imbalance of immune system.

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Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis

Cited by 115 publications

References 106 publications

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Signaling networks controlling ID and E protein activity in T cell differentiation and function

Effect of short PSG peptide fragments on the cytokine profile in Wistar rats during allogeneic transplantation <i>in vivo</i>

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