Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes

Identification of Shared Biomarkers and Immune Infiltration Signatures between Vitiligo and Hashimoto’s Thyroiditis

“… 29 In the mouse model, the neutralization of CXCL10 was able to reverse the depigmentation partially. The upregulation of the level of CXCL10 was also found in the serum and tissue of HT patients 30 with a higher titer in those with a more aggressive thyroid autoimmune process such as hypothyroidism or a hypoechoic ultrasonographic pattern. 31 CXCL10 is absent in normal human thyrocytes but could be triggered by synergistic stimulation of IFN-γ and TNF-α in a dose-dependent pattern.…”

Ultrafast screening of serum for early prediction of diabetes by fractalkine detection

“…Clinical studies performed by Sindhu et al 15 using immunofluorescence showed concentrations of FKN significantly higher in type 2 diabetes subjects (higher than 166 ± 14.22 pg mL −1 ) versus healthy subjects (lower than 118 ± 8.90 pg mL −1 ). We also performed some clinical studies regarding the level of concentrations in prediabetes, obese, and healthy subjects using immunofluorescence and the screen-printed stochastic sensor developed by us; 16 elevated levels of FKN were observed in prediabetes subjects (higher than 221.93 ± 18.46 pg mL −1 ) versus obese subjects (between 182.89 and 191.5 pg mL −1 ) or healthy subjects (less than 150.22 ± 67.14 pg mL −1 ). The linear concentration range (2.05 fg mL −1 and 0.5 μg mL −1 ) in which the stochastic sensor can be used covered well all categories: diabetic and prediabetic subjects, as well as healthy subjects.…”