1995
DOI: 10.1001/archotol.1995.01890020064013
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Interleukin-8 Expression by Head and Neck Squamous Cell Carcinoma

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Cited by 87 publications
(41 citation statements)
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“…GRO-a is an autocrine growth factor identi®ed in melanoma (Balentien et al, 1991), and is a member of the C-X-C family of chemokines which promote chemotaxis of granulocytes and endothelia (Strieter et al, 1996). We and others have found that human SCC also produce C-X-C chemokines with potential proin¯ammatory and proangiogenic activity, including IL-8 Cohen et al, 1995;Smith et al, 1994) and GRO-a (Loukinova, unpublished results). mGRO-a shares major sequence homology and leukocyte chemotactic activity (Oquendo et al, 1989;Bozic et al, 1995) with both human GRO-a and IL-8, for which independent murine counterparts have not been identi®ed.…”
Section: Introductionmentioning
confidence: 64%
“…GRO-a is an autocrine growth factor identi®ed in melanoma (Balentien et al, 1991), and is a member of the C-X-C family of chemokines which promote chemotaxis of granulocytes and endothelia (Strieter et al, 1996). We and others have found that human SCC also produce C-X-C chemokines with potential proin¯ammatory and proangiogenic activity, including IL-8 Cohen et al, 1995;Smith et al, 1994) and GRO-a (Loukinova, unpublished results). mGRO-a shares major sequence homology and leukocyte chemotactic activity (Oquendo et al, 1989;Bozic et al, 1995) with both human GRO-a and IL-8, for which independent murine counterparts have not been identi®ed.…”
Section: Introductionmentioning
confidence: 64%
“…In recent years, studies have shown that IL-8 is closely associated with the occurrence of tumors. The secretion and expression of IL-8 mRNA and protein have been detected in many tumor tissues and GA cell lines (Cohen et al, 1995;Brew et al, 1996;Yoshimura et al, 2002). Promoter regions of a number of cytokine genes contain polymorphisms that directly influence cytokine production (Bidwell et al, 2001).…”
Section: Lack Of Association Of a Common Polymorphism In The 3' -Utr mentioning
confidence: 99%
“…Among the repertoire of cytokines detected in HNSCC cells, IL-8 is a pro-in¯ammatory and proangiogenic cytokine consistently expressed at elevated concentrations in tumor specimens, cell lines, and serum from patients relative to controls [2,5,6], and the IL-8 promoter contains NF-kB, AP-1, and NF-IL6 binding sites that have been shown to promote inducible IL-8 gene expression in response to various stimuli [13,36]. To examine the functional importance of NF-kB, AP-1, and NF-IL6 sites present in the proximal region of the IL-8 promoter, we performed luciferase reporter gene assays in UM-SCC-9 cells by using plasmids that contain a wildtype 133-bp IL-8 promoter fragment or mutagenized NF-kB, AP-1, and NF-IL6 sites [36].…”
Section: Nf-kb and Ap-1 Sites In The Il-8 Promoter Involved In Cytokimentioning
confidence: 99%