Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

Candel-Marti, Maria-Eugenia; Flichy-Fernández, Antonio-Juan; Alegre-Domingo, Teresa; Ata-Ali, Javier; Peñarrocha-Diago, María

doi:10.4317/medoral.16.e518

Cited by 46 publications

(36 citation statements)

References 9 publications

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“…A similar danger signal-related release of mediators like IL-1 β or IL-6 has also been observed in Ti dental implant patients with peri-implantitis [23]. …”

Section: Introductionsupporting

confidence: 53%

“…Correspondingly, Nowzari et al concluded from their experiments that there is an inevitable and ongoing spectrum of microorganisms and interleukins around teeth and implants [55]. There is, however, still controversy about the interplay and significance of the different interleukins in crevicular fluid and peri-implantitis [23]. At present, we know little about the immune mechanisms leading to well-tolerated Ti dental implants, but our results indicate that adaptive mechanisms may exist.…”

Section: Discussionmentioning

confidence: 76%

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Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Thomas

Iglhaut

Wollenberg

et al. 2013

BioMed Research International

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Hypersensitivity reactions to titanium (Ti) are very rare. Thus, we assessed the proinflammatory response and also potential tolerance favoring in vitro reactivity of human blood lymphocytes and monocytes (PBMC) to Ti in healthy individuals (14 without, 6 with complication-free dental Ti implants). The proliferation index (SI) in lymphocyte transformation test (LTT) and production of cytokines linked to innate immune response (IL-1β, IL-6, and TNFα) or immune regulation (IL-10) were assessed in response to TiO2 particles or Ti discs. In both groups, the Ti-LTT reactivity was not enhanced (e.g., SI < 3). The control antigen tetanus toxoid (TT) gave adequate reactivity (median SI individuals without/with implant: 20.6 ± 5.97/19.58 ± 2.99). Individuals without implant showed higher cytokine response to Ti materials than individuals with symptom-free implants; for example, TiO2 rutile particle induced increase of IL-1β 70.27-fold/8.49-fold versus control medium culture. PBMC of 5 of the 6 individuals with complication-free Ti implants showed an ex vivo ongoing production of IL-10 (mean 4.18 ± 2.98 pg/mL)-but none of the 14 controls showed such IL-10 production. Thus in vitro IL-1β-, IL-6-, and TNF-α production reflects “normal” unspecific immune response to Ti. This might be reduced by production of tolerogenic IL-10 in individuals with symptom-free Ti dental implants.

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“…A similar danger signal-related release of mediators like IL-1 β or IL-6 has also been observed in Ti dental implant patients with peri-implantitis [23]. …”

Section: Introductionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 76%

Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Thomas

Iglhaut

Wollenberg

et al. 2013

BioMed Research International

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“…The maintenance of bone volume is regulated by balanced processes of apposition and resorption; these processes are controlled in part by the local production of cytokines, small polypeptides with a wide range of pro‐inflammatory, metabolic, and immunomodulatory properties 11,12 . For example, interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α are potent pro‐inflammatory cytokines 11 that are involved in the pathogenesis of many chronic inflammatory diseases (e.g., peri‐implantitis 13 ) and are present in peri‐implant crevicular fluid (PICF) 14‐17 . The titanium surfaces of dental implants can stimulate peripheral blood mononuclear cells to secrete IL‐1β, TNF‐α, 18 IL‐1, IL‐6, and IL‐18 19 in vitro, indicating that dental implants are not biochemically inert.…”

mentioning

confidence: 99%

Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Nogueira-Filho

Pesun

Isaak-Ploegman

et al. 2014

Journal of Periodontology

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“…According to clinical surveys, peri-implantitis develops in 12-43 % of cases, mucositis -in 60-80 % of patients with dental implants. Symptoms of inflammation can occur both immediately after the implantation, and in the long run (in many months or even years) [6]. There is no reliable data indicating which treatment (therapeutic, surgical) may be most effective in these diseases.…”

Section: Introductionmentioning

confidence: 99%

Indicators of the Cytokine System as Markers for the Complications Development in Patients Who Went Through Dental Implantation

Matolych

2017

Technology transfer: innovative solutions in medicine

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According to clinical surveys, peri-implantitis develops in 12–43% of cases, mucositis — in 60-80% of patients with dental implants. The universal regulatory function is performed by immune system mediators – cytokines (interleukins – IL). The purpose of this research is to determine the functional condition of the cytokine system in blood serum at dental implantation in order to improve the early diagnosis of inflammatory complications. The research aim: to find out the features of immunological parameters changes in peripheral blood at mucositis, peri-implantitis in dynamics. Depending on the nosological nature of the inflammatory complications that arose in the peri-implant zone at the initial stage, the patients were divided into two groups: 1st – 14 patients with dental mucositis, 2nd – 12 patients with dental peri-implantitis of the I-II degree. The control group consisted of 15 patients who had no inflammatory complications.The level of IL-6, IL-8 and IL-17 in blood serum was defined by applying enzyme multiplied immunoassay using the set of chemical agents “Diaclone”. There were no probable changes in the cytokines system with mucositis. The obtained results of laboratory and clinical studies indicate that dental peri-implantitis features with decrease in IL-6, increase in IL-8, IL-17 levels. That is why implantation requires thorough preliminary diagnostics, namely determination of patients' cytokine status. Assessment of the functional condition of the body cytokines system may be important for determining the strategy of dental implantation and prevention of early postoperative complications

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Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

Cited by 46 publications

References 9 publications

Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Allergy or Tolerance: Reduced Inflammatory Cytokine Response and Concomitant IL-10 Production of Lymphocytes and Monocytes in Symptom-Free Titanium Dental Implant Patients

Longitudinal Comparison of Cytokines in Peri‐Implant Fluid and Gingival Crevicular Fluid in Healthy Mouths

Indicators of the Cytokine System as Markers for the Complications Development in Patients Who Went Through Dental Implantation

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