Interleukins levels associated with Chronic Otitis Media (CSOM)

Saleh, Anas Ahmed; Tektook, Nihad Khalawe; Rasheed, Inas Abd Al Majed

doi:10.5958/0974-360x.2019.01004.7

Rese. Jour. of Pharm. and Technol.

2019

DOI: 10.5958/0974-360x.2019.01004.7

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Interleukins levels associated with Chronic Otitis Media (CSOM)

Anas Ahmed Saleh¹,

Nihad Khalawe Tektook²,

Inas Abd Al Majed Rasheed³

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2023

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Cited by 3 publications

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The most common route of administration used during COVID-19

Khalil¹,

Hameed²,

Hanna³

2023

AJPS

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the virus that caused the COVID-19 pandemic. Initial symptoms include fever, cough, and dyspnea. Symptoms include nausea, vomiting, and abdominal pain, GIT involvement is also possible. The COVID-19 outbreak has increased the need for alternative medicine administration routes, particularly in public places. Buccal, sublingual, and rectal administration are all considered transmucosal methods. They are self-administration options for non-invasive systemic distribution. In addition, they are great for use in palliative and end-of-life care because of their quick onset of action and decreased first-pass metabolism. A mucosal atomization device allows for the intranasal administration of a parenteral formulation through nasal spray. Rectal mucosal absorption is comparable to that of the oral route, making the rectal route an extremely versatile and useful method of drug administration for a wide variety of medications. Covid-19 illness is treated with a variety of drugs, including anti-malaria medication (hydroxychloroquine), glucocorticoids (dexamethasone), antibiotics (azithromycin), and antiviral medications (favipiravir). This article discusses the route of drug administration for COVID-19, as well as symptoms, treatments, and the various ways it can be spread

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The most common route of administration used during COVID-19

Khalil¹,

Hameed²,

Hanna³

2023

AJPS

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Quantification of Interleukins in the Serum: A Non-invasive markers of Endometriosis

Balunathan,

Perumal

et al. 2023

RJPT

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Background: Endometriosis is a common gynaecological disease, with many theories on the endometriosis pathogenesis in association with the regulation of cell multiplication and neo-angiogenesis. Objective: The current study is a case control estimation of Interleukin 4 and Interleukin 18 in women with endometriosis, compared with that of a control group of healthy women without endometriosis. Methods: Peripheral blood samples were collected from the study groups: 40 women with endometriosis and 40 women without non-endometriosis. Concentration of cytokines, IL-4 and IL-18 were estimated using ELISA method. Results: Results showed that the concentration of both IL-4 and IL-18 serum were significantly higher in women with endometriosis when compared with women without endometriosis group (p=0.0005). Conclusion: Cytokines play their specific roles in pathogenesis of endometriosis. IL-4 and IL-18 cytokines could be used as a biomarker for non-invasive test for endometriosis. Further studies are needed with more data to determine their role as a biomarker for endometriosis.

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Effect of Acetic Acid on Clinical Isolated Pseudomonas aeruginosa Biofilm in Chronic Suppurative Otitis Media: In vitro Study

Artono,

Nisa Janitra,

Purnami

et al. 2023

RJPT

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Background: Forming biofilms on bacteria can inhibit the penetration of antimicrobial agents and avoid the immune defence system. It becomes one of the factors causing therapy failure and chronicity of infection. Pseudomonas aeruginosa is the most common bacteria found in Chronic Suppurative Otitis Media (CSOM), which has the virulence ability to form biofilm structures. Some studies have reported that acetic acid can inhibit and eradicate biofilm complexes and is thought to be an alternative to additional therapy against bacterial infections that form biofilms. Objective: to explain the effect of acetic acid inhibiting and eradicating Pseudomonas aeruginosa biofilm in CSOM. Methods: This study used an experimental in vitro laboratory with a post-test-only control group method. Samples were taken from the secretions of the mastoid cavity of CSOM patients. The inhibitory effect of acetic acid was observed by administering acetic acid to Pseudomonas aeruginosa. In contrast, the effect of eradicating biofilm was observed by administering acetic acid to Pseudomonas aeruginosa which had already formed a biofilm. The observations in this study were using the microtiter plate assay method and were measured with an ELISA reader. Data analysis used the One-Way Anova test and multiple comparisons (Tukey HSD Test). Result: The inhibitory effect of acetic acid on the growth of Pseudomonas aeruginosa biofilm was obtained (p=0.000) with significant results (p <0.05) between the positive control group and the concentration group of 0.16%, 0.31%, 0.63%, 1.25%, 2.5%, and 5%. The Minimum Biofilm Inhibitory Concentration (MIBC) value of acetic acid in forming Pseudomonas aeruginosa biofilms was 0.16%. The effect of acetic acid eradication on Pseudomonas aeruginosa biofilms (p=0.000) with significant results (p<0.05) between the positive control group and the concentration group of 0.08%, 0.16%, 0.31%, 0.63%, 1.25%, 2.5%, and 5%. While the minimum value of acetic acid Biofilm Eradication Concentration (MEBC) for Pseudomonas aeruginosa biofilm eradication was 0.08%. Conclusion: Acetic acid inhibits the formation and eradication of Pseudomonas aeruginosa biofilms in CSOM.

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Interleukins levels associated with Chronic Otitis Media (CSOM)

Cited by 3 publications

References 0 publications

The most common route of administration used during COVID-19

The most common route of administration used during COVID-19

Quantification of Interleukins in the Serum: A Non-invasive markers of Endometriosis

Effect of Acetic Acid on Clinical Isolated Pseudomonas aeruginosa Biofilm in Chronic Suppurative Otitis Media: In vitro Study

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