Intermittent administration of parathyroid hormone ameliorated alveolar bone loss in experimental periodontitis in streptozotocin-induced diabetic rats

Chen, Helin; Fu, Taozi; Ma, Yuanyuan; Wu, Xiangnan; Li, Xianxian; Shen, Jiefei; Wang, Hang

doi:10.1016/j.archoralbio.2017.06.033

Cited by 16 publications

(10 citation statements)

References 34 publications

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“…In addition, using computed tomography to assess bone mineral changes in different parts of the alveolar bone may be useful for examining in detail how periodontitis affects alveolar bone metabolism. Furthermore, controlling calcium metabolism by calcium‐regulating hormones, such as parathyroid hormone and calcitonin, may have clinical significance for suppressing alveolar bone loss 63‐66 . However, in view of the site‐specific changes in calcium metabolism in periodontitis, it would be desirable to administer these drugs locally, not systemically, and more proximal to the inflammation.…”

Section: Discussionmentioning

confidence: 99%

Periodontal inflammation triggers a site‐specific and wide radius of calcium metabolic effects on alveolar bone

Kuraji

Hashimoto

et al. 2020

J of Periodontal Research

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Background and Objective There is a close relationship between inflammation and bone remodeling in the periodontium. However, previous studies have not delineated the alterations in calcium (Ca) metabolism during periodontitis progression. The aim of this current investigation was to examine Ca dynamics in alveolar bone of rats during progression of ligature‐induced periodontal inflammation by using 45Ca, which is an index of hard tissue neogenesis. Material and Methods To induce periodontitis, the maxillary right first molar (M1) of 8‐week‐old male rats was ligated with a silk suture for 1, 3, 7, and 28 days. The left M1 was not ligated as a control. To evaluate resultant changes in bone neogenesis, 45CaCl2 was injected intraperitoneally 24 hours before euthanasia. The left‐and‐right palatal mucosa, molar teeth (M1 and M2), and alveolar bone were harvested for evaluation of 45Ca radioactivity using a liquid scintillation counter. The distribution of 45Ca in maxillary tissues was evaluated using autoradiography (ARG). In addition, we analyzed the bone volume fraction (BV/TV) and bone mineral density (BMD) of the alveolar bone by micro‐computed tomography. To investigate the number of osteoclasts and osteoblasts, tartrate‐resistant acid phosphatase (TRAP) and bone‐specific alkaline phosphatase (BAP) were measured by an enzymatic assay and immunohistochemistry, respectively. Results 45Ca radioactivity in the alveolar bone of the ligature side decreased by 8% compared to the unligated control‐side on day 1, whereas on day 7, it markedly increased by 33%. The 45Ca levels in the gingival tissue and molar teeth were slightly but significantly lower than the control‐side on day 1 and higher from day 3 to 28. The variation in 45Ca levels for the alveolar bone was greater and specific compared with other tissues. Furthermore, on day 7, ARG data revealed that 45Ca on the control side was primarily localized to the periodontal ligament (PDL) space and alveolar bone crest and barely detected in the gingival tissues and deeper parts of the alveolar bone. On the ligature side, 45Ca disappeared from the PDL and alveolar crest, but instead was broadly and significantly increased within the deeper zones of the alveolar bone and furcation areas and distant from the site of ligature placement and periodontal inflammation. In the shallow zone of the alveolar bone, these changes in 45Ca levels on day 7 were consistent with decreases in the bone structural parameters (BV/TV and BMD), enhanced osteoclast presence, and suppressed levels of BAP expression in osteoblasts. In contrast, the deep zone and furcation area showed that TRAP‐positive cells increased, but BAP expression was maintained in the resorption lacunae of the alveolar bone. Conclusion During periodontitis progression in rats, 45Ca levels in the alveolar bone exhibited biphasic alterations, namely decreases and increases. These data indicate that periodontitis induces a wide range of site‐specific Ca metabolism alterations within the alveolar bone.

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Section: Discussionmentioning

confidence: 99%

Periodontal inflammation triggers a site‐specific and wide radius of calcium metabolic effects on alveolar bone

Kuraji

Hashimoto

et al. 2020

J of Periodontal Research

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“…PTH is an important hormone to regulate the bone metabolism. PTH has been shown to reduce the alveolar bone loss in the intermittent and systemic administrations by decreasing the RANKL/OPG ratio in diabetic rats (119). However, some studies found that PTH did not improve the post-extraction wound healing or stimulate the osseointegration in hyperglycemic rats, regardless of administration of PTH (intermittent versus continuous) (120).…”

Section: Molecular Targetsmentioning

confidence: 99%

Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction

Yang

Liu

et al. 2022

Front. Endocrinol.

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Diabetes mellitus is a common systematic chronic disease amongst dental patients. The elevated glucose microenvironment can prolong the healing of tooth extraction sockets. Therefore, the promotion of healing up tooth extraction sockets is of great clinical importance to the patients with diabetes mellitus. The current evidence indicates the mechanism of the recovery period of extraction sockets in hyperglycaemia conditions from physiological, inflammation, immune, endocrine and neural aspects. New advancements have been made in varied curative approaches and drugs in the management of wound healing of tooth extraction sockets in diabetes. However, most of the interventions are still in the stage of animal experiments, and whether it can be put into clinical application still needs further explorations. Specifically, our work showed topical administration of plasma-rich growth factor, advanced platelet-rich fibrin, leukocyte- and platelet-rich fibrin and hyaluronic acid as well as maxillary immediate complete denture is regarded as a promising approach for clinical management of diabetic patients requiring extractions. Overall, recent studies present a blueprint for new advances in novel and effective approaches for this worldwide health ailment and tooth extraction sockets healing.

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“…A variety of studies using both animal models and clinical trials have suggested a promising outcome for PTH treatment in periodontitis. PTH-treated periodontitis rodents had reduced alveolar bone resorption and milder infiltration of inflammatory cells at the marginal gingiva ( Barros et al, 2003 ; Chen et al, 2017 ). PTH applied to rats with partially removed PDL and cementum attenuated the extension of the bone defect, increased total callus bone, and accelerated the formation of cementum-like tissue at the healing site ( Vasconcelos et al, 2014 ).…”

Section: Therapeutic Application Of Parathyroid Hormone/parathyroid Hormone-related Protein In Orofacial Regionmentioning

confidence: 99%

Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

Lyu

et al. 2021

Front. Cell Dev. Biol.

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Parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) are two peptides that regulate mineral ion homeostasis, skeletal development, and bone turnover by activating parathyroid hormone 1 receptor (PTH1R). PTH1R signaling is of profound clinical interest for its potential to stimulate bone formation and regeneration. Recent pre-clinical animal studies and clinical trials have investigated the effects of PTH and PTHrP analogs in the orofacial region. Dental mesenchymal stem cells (MSCs) are targets of PTH1R signaling and have long been known as major factors in tissue repair and regeneration. Previous studies have begun to reveal important roles for PTH1R signaling in modulating the proliferation and differentiation of MSCs in the orofacial region. A better understanding of the molecular networks and underlying mechanisms for modulating MSCs in dental diseases will pave the way for the therapeutic applications of PTH and PTHrP in the future. Here we review recent studies involving dental MSCs, focusing on relationships with PTH1R. We also summarize recent basic and clinical observations of PTH and PTHrP treatment to help understand their use in MSCs-based dental and bone regeneration.

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Intermittent administration of parathyroid hormone ameliorated alveolar bone loss in experimental periodontitis in streptozotocin-induced diabetic rats

Cited by 16 publications

References 34 publications

Periodontal inflammation triggers a site‐specific and wide radius of calcium metabolic effects on alveolar bone

Periodontal inflammation triggers a site‐specific and wide radius of calcium metabolic effects on alveolar bone

Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction

Parathyroid Hormone 1 Receptor Signaling in Dental Mesenchymal Stem Cells: Basic and Clinical Implications

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