Intermittent bacteremia detected in an asymptomatic apheresis platelet donor with repeat positive culture for <i>Escherichia coli</i>: a case report

Ramírez‐Arcos, Sandra; Alport, Ted; Goldman, Mindy

doi:10.1111/trf.13218

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…It is reasonable to consider that such a donor harbours some pathological status that allows the occurrence of intermittent bacteraemia. In Canada, Escherichia coli was detected twice in PC collected from the same donor, and the donor was permanently deferred after identifying multiple diverticula in his colon [12]. In our cases, two TTBIs were caused by the same bacteria derived from consecutive blood collections from the same donor.…”

Section: Discussionmentioning

confidence: 74%

Two cases of Streptococcus dysgalactiae subspecies equisimilis infection transmitted through transfusion of platelet concentrate derived from separate blood donations by the same donor

et al. 2023

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Background Transfusion‐transmitted bacterial infections (TTBIs) in Japan have been largely prevented due to a short shelf life of 3.5 days after blood collection for platelet concentrate (PC) and washed PCs (WPCs; PC in which 95% plasma is replaced by platelet additive solution). Case Presentation Case 1: In January 2018, a woman in her 50s with aplastic anaemia who received WPC transfusion and developed a fever the next day and Streptococcus dysgalactiae subspecies equisimilis (SDSE) was detected in the residual WPC. Case 2: In May 2018, a man in his 60s with a haematologic malignancy who received PC transfusion and developed chills during the transfusion. SDSE was detected in the patient's blood and residual PC. The contaminated platelet products were both manufactured from blood donated by the same donor. The multi‐locus sequencing typing revealed that SDSE detected in case 1 was identical to that from case 2; however, whole blood subsequently obtained from the donor was culture negative. Conclusion WPC and PC produced from two blood donated 106 days apart by the same donor were contaminated with SDSE of the same strain and both caused TTBIs. Safety measures should be considered regarding blood collection from a donor with a history of bacterial contamination.

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Section: Discussionmentioning

confidence: 74%

Two cases of Streptococcus dysgalactiae subspecies equisimilis infection transmitted through transfusion of platelet concentrate derived from separate blood donations by the same donor

et al. 2023

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“…The two main origins of BC contaminants are the skin and the blood of the donor through transient bacteremia. 5,39 Regarding the second mechanism, there are two different options, either an asymptomatic transient bacteremia involving a nonvirulent bacterial strain, such as viridans streptococci after teeth brushing, or a pauci-symptomatic real bacteremia involving a highly virulent strain. 2 The phylogenetic analysis, virulence score, and mouse assay clearly supported the second hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion‐transmitted bacterial infections: implications for preventive strategies

et al. 2018

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“…13 E. coli, Orientia tsutsugamushi, and Plasmodium sp. have proved to be associated with transfusion in many countries, [14][15][16][17] and the other identified pathogens could also have a bad influence on blood safety. Therefore, as to the abovementioned pathogens, prevalence and incidence investigations are needed to determine the specific transfusion risks.…”

Section: Discussionmentioning

confidence: 99%

Metagenomics in pooled plasma, with identification of potential emerging infectious pathogens

Yang

et al. 2017

Transfusion

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Intermittent bacteremia detected in an asymptomatic apheresis platelet donor with repeat positive culture for Escherichia coli: a case report

Abstract: This asymptomatic donor has intermittent bacteremia likely related to diverticular disease. Isolation of E. coli twice prompted further investigation and donor deferral.

Cited by 10 publications

References 21 publications

Two cases of Streptococcus dysgalactiae subspecies equisimilis infection transmitted through transfusion of platelet concentrate derived from separate blood donations by the same donor

Two cases of Streptococcus dysgalactiae subspecies equisimilis infection transmitted through transfusion of platelet concentrate derived from separate blood donations by the same donor

Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion‐transmitted bacterial infections: implications for preventive strategies

Metagenomics in pooled plasma, with identification of potential emerging infectious pathogens

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