Intermittent fasting enhances hippocampal NPY expression to promote neurogenesis after traumatic brain injury

Cao, Shuqiang; Li, Manrui; Sun, Yuhui; Wu, Peiyan; Yang, Wenjie; Dai, Hao; Guo, Yadong; Ye, Yi; Wang, Zheng; Xie, Xiaoqi; Chen, Xiameng; Liang, Weibo

doi:10.1016/j.nut.2022.111621

Cited by 20 publications

(28 citation statements)

References 32 publications

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“…Upon close examination of the available literature on IF in rodents, we wonder whether publication bias might be playing a role in skewing it towards reporting positive results. We noticed high diversity in its effects on adult neurogenesis, with an overwhelming majority of reports showing variable positive impact (Apple et al, 2019;Baik et al, 2020;Brandhorst et al, 2015;Cao et al, 2022;Dias et al, 2021;Kaptan et al, 2015;Kim et al, 2015;Kitamura et al, 2006;Kumar et al, 2009;Lee et al, 2000;Lee et al, 2002b;Lee et al, 2002a;Li et al, 2020;Park et al, 2013;Wu et al, 2008) and very few showing no effect or a mild impairment (Bondolfi et al, 2004;Staples et al, 2017). In some reviews, even studies reporting no effect are cited as evidence for improved neurogenesis upon IF.…”

Section: Discussionmentioning

confidence: 99%

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

Gabarró-Solanas

Davaatseren

Kepcija

et al. 2022

Preprint

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Intermittent fasting (IF) is a promising non-pharmacological strategy to counteract ageing which has been shown to increase the number of adult-born neurons in the dentate gyrus of mice. However, it is still unclear which steps of the adult neurogenesis process are regulated by IF. The number of adult neural stem cells (NSCs) decreases with age in an activation-dependent manner. To counteract the loss of the stem cell pool, adult NSCs are mostly found in an inactive, quiescent state which ensures their long-term maintenance. We aimed to determine if and how IF impacts the activity and maintenance of adult NSCs in the hippocampus. We chose an every-other-day fasting protocol with food re-administration at night, which we found effectively induces fasting features and preserves the circadian activity pattern of mice. To determine the effects of IF on NSCs and all following steps in the neurogenic lineage, we combined fasting with lineage tracing and label retention assays. We found that IF does not affect NSC activation or maintenance. Contrary to previous reports, we also found that IF does not increase hippocampal neurogenesis. We obtained the same results regardless of strain, sex, diet length, tamoxifen administration or new-born neuron identification method. Our data suggest that NSCs maintain homeostasis upon IF and that this intervention is not a reliable strategy to increase adult neurogenesis.

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Section: Discussionmentioning

confidence: 99%

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

Gabarró-Solanas

Davaatseren

Kepcija

et al. 2022

Preprint

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“…These results raised the following questions: (1) Does the 1-month IF regimen promote or inhibit hippocampal basal cell proliferation following TBI? (2) If the fasting regimen was prolonged to 3 months, would there be any difference in the behavior of NSCs in the SGZ as we reported [ 48 ]?…”

Section: Neuroprotective Effects Of Cr and If In Tbimentioning

confidence: 94%

“…Hippocampal dysfunction is a major pathological aspect of TBI that generally affects patients’ spatial learning and memory [ 62 , 63 , 64 , 65 ]. We recently found that a 1-month IF regimen other than acute fasting prior to CCI significantly enhanced the proliferation of neural stem cells (NSCs) in the subgranular zone (SGZ) of the hippocampus and improved cognitive function postinjury [ 48 ]. A subsequent loss of function study demonstrated that the neurogenesis-promoting effect of IF following TBI was achieved by increasing the neuronal NPY expression in the hippocampus [ 48 ].…”

Section: Neuroprotective Effects Of Cr and If In Tbimentioning

confidence: 99%

“…We recently found that a 1-month IF regimen other than acute fasting prior to CCI significantly enhanced the proliferation of neural stem cells (NSCs) in the subgranular zone (SGZ) of the hippocampus and improved cognitive function postinjury [ 48 ]. A subsequent loss of function study demonstrated that the neurogenesis-promoting effect of IF following TBI was achieved by increasing the neuronal NPY expression in the hippocampus [ 48 ]. Our study, contrary to that of Davis, suggests the health benefits of an IF regimen in TBI and its underlying mechanisms.…”

Section: Neuroprotective Effects Of Cr and If In Tbimentioning

confidence: 99%

“…To improve the quality of life for patients suffering from TBI, the search for more effective interventions for TBI has to continue. Our study recently found that a 1-month IF regimen prior to TBI significantly improved cognitive function following the insult, in which Npy (Neuropeptide Y)-induced neurogenesis made a contribution [ 48 ]. In addition, several studies have shown that multiple FR regimens, mainly CR and IF, exert positive effects on the development of TBI via various mechanisms [ 19 , 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

Yang

Liu

et al. 2022

Nutrients

Self Cite

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It has widely been accepted that food restriction (FR) without malnutrition has multiple health benefits. Various calorie restriction (CR) and intermittent fasting (IF) regimens have recently been reported to exert neuroprotective effects in traumatic brain injury (TBI) through variable mechanisms. However, the evidence connecting CR or IF to neuroprotection in TBI as well as current issues remaining in this research field have yet to be reviewed in literature. The objective of our review was therefore to weigh the evidence that suggests the connection between CR/IF with recovery promotion following TBI. Medline, Google Scholar and Web of Science were searched from inception to 25 February 2022. An overwhelming number of results generated suggest that several types of CR/IF play a promising role in promoting post-TBI recovery. This recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. Further, we represent our views on the current issues and provide thoughts on the future direction of this research field.

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Cellular Adaptations to Intermittent Fasting with Emphasis on the Brain

Mattson

2024

Intermittent and Periodic Fasting, Aging and Disease

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Intermittent fasting enhances hippocampal NPY expression to promote neurogenesis after traumatic brain injury

Cited by 20 publications

References 32 publications

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

Adult neural stem cells and neurogenesis are resilient to intermittent fasting

Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

Cellular Adaptations to Intermittent Fasting with Emphasis on the Brain

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