Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons

Dasgupta, Ananya; Kim, Joonki; Manakkadan, Anoop; Sajikumar, Sreedharan

doi:10.1016/j.nlm.2017.12.004

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…For example, the effect of IF a well as neurogenesis and synaptic plasticity was demonstrated to involve BDNF/TrkB signaling [35]. Previous studies have described IF as a metaplastic priming signal extending the duration of tags and thus the time window between activations [45].…”

Section: Neurotrophic Effects Of If Via Bdnf and Bfgfmentioning

confidence: 99%

Neuroprotective Effects of Intermittent Fasting in the Aging Brain

Dong,

Wang,

et al. 2024

Ann Nutr Metab

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Background: A major risk factor for neurodegenerative disorders is old age. Nutritional interventions that delay aging, such as calorie restriction (CR) and intermittent fasting (IF), as well as pharmaceuticals that affect the pathways linking nutrition and aging processes, have been developed in recent decades and have been shown to alleviate the effects of aging on the brain. Summary: CR is accomplished by alternating periods of ad libitum feeding and fasting. In animal models, IF has been shown to increase lifespan and slow the progression and severity of age-related pathologies such as cardiovascular and neurodegenerative diseases and cancer. According to recent research, dietary changes can help older people with dementia retain brain function. However, the mechanisms underlying the neuroprotective effect of IF on the aging brain and related questions in this area of study (i.e., the potential of IF to treat neurodegenerative disorders) remain to be examined. Key Messages: This review addresses the hypothesis that IF may have translational potential in protecting the aged brain while summarizing the research supporting the putative neuroprotective mechanisms of IF in animal models. Additionally, given the emerging understanding of the connection between aging and dementia, our investigations may offer a fresh perspective on the use of dietary interventions for enhancing brain function and preventing dementia in elderly individuals. Finally, the absence of guidelines regarding the application of IF in patients hampers its broad utilization in clinical practice, and further studies are needed to improve our knowledge of the long-term effects of IF on dementia before it can be widely prescribed. In conclusion, IF may be an ancillary intervention for preserving memory and cognition in elderly individuals.

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Section: Neurotrophic Effects Of If Via Bdnf and Bfgfmentioning

confidence: 99%

Neuroprotective Effects of Intermittent Fasting in the Aging Brain

Dong,

Wang,

et al. 2024

Ann Nutr Metab

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“… 34 Intermittent fasting also contributes to neuronal synaptic plasticity by controlling the secretion of neurotransmitters including serotonin, noradrenaline, and dopamine. 35 Intermittent fasting additionally improves the impairment of synaptic plasticity in hippocampal neurons 36 and enhances autonomic synaptic plasticity, 37 subsequently rescuing cognitive impairment. 38 …”

Section: The Effects Of Intermittent Fasting In Dementiamentioning

confidence: 99%

Intermittent Fasting: a Promising Approach for Preventing Vascular Dementia

Yoon

Song

2019

J Lipid Atheroscler

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Vascular dementia is the most common neuropsychiatric syndrome and is characterized by synaptic dysfunction, neuroinflammation, and cognitive dysfunction. Vascular dementia is associated with various environmental, genetic, and lifestyle risk factors. Recent research has focused on the association between vascular dementia and dietary patterns, suggesting that dietary regulation leads to better control of energy metabolism, improvements in brain insulin resistance, and the suppression of neuroinflammation. Intermittent fasting is a calorie-restriction method known to be more effective in promoting fat loss and regulating the impairment of glucose metabolism as compared with other dietary restriction regimens. Herein, the authors review the effects of intermittent fasting with regard to vascular dementia based on recent evidence and propose that intermittent fasting could be a therapeutic approach for ameliorating vascular dementia pathology and preventing its onset.

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“…Cellular/molecular pathways encompass: delayed oxidative stress and improved bioenergetics (Merry, 2004;Hunt et al, 2006;Mattson and Arumugam, 2018;Bayliak et al, 2021;Green et al, 2022), increased protein chaperone activity (Arumugam et al, 2010), reduced inflammation (Spaulding et al, 1997;Bhattacharya et al, 2006;Ugochukwu and Figgers, 2007), or by increased neurogenesis and upregulation of neurotrophic factors (Lee et al, 2002;Cheng et al, 2003;Joseph D'Ercole and Ye, 2008;Mattson, 2010;Vasconcelos et al, 2021;Dias et al, 2021). Interestingly, synaptic function was shown to improve following only days (Campanelli et al, 2021) or months (Dasgupta et al, 2018) of diet restriction or IF. Because many of these cellular mechanisms are ultimately reflected in changes in synaptic signals and/or calcium homeostasis, we focused on synaptic transmission and calcium signaling during IF.…”

Section: Introductionmentioning

confidence: 99%

Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons

et al. 2021

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Aging is often associated with cognitive decline and recurrent cellular and molecular impairments. While life-long caloric restriction (CR) may delay age-related cognitive deterioration as well as the onset of neurologic disease, recent studies suggest that late-onset, short-term intermittent fasting (IF), may show comparable beneficial effects as those of life-long CR to improve brain health. We used a new optogenetic aging model to study the effects of late-onset (.18 months), short-term (four to six weeks) IF on age-related changes in GABAergic synaptic transmission, intracellular calcium (Ca 21 ) buffering, and cognitive status. We used male mice from a bacterial artificial chromosome (BAC) transgenic mouse line with stable expression of the channelrhodopsin-2 (ChR2) variant H134R [VGAT-ChR2(H134R)-EYFP] in a reduced synaptic preparation that allows for specific optogenetic light stimulation on GABAergic synaptic terminals across aging. We performed quantal analysis using the method of failures in this model and show that short-term IF reverses the age-related decrease in quantal content of GABAergic synapses. Likewise, short-term IF also reversed age-related changes in Ca 21 buffering and spontaneous GABAergic synaptic transmission in basal forebrain (BF) neurons of aged mice. Our findings suggest that late-onset shortterm IF can reverse age-related physiological impairments in mouse BF neurons but that four weeks IF is not sufficient to reverse age-related cognitive decline.

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Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons

Cited by 10 publications

References 47 publications

Neuroprotective Effects of Intermittent Fasting in the Aging Brain

Neuroprotective Effects of Intermittent Fasting in the Aging Brain

Intermittent Fasting: a Promising Approach for Preventing Vascular Dementia

Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons

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