Intermittent Hypoxia and Experimental Parkinson’s Disease

Belikova, M. V.; Колесникова, Е. Э.; Serebrovskaya, Tatiana V.

doi:10.1007/978-1-4471-2906-6_12

Cited by 11 publications

(7 citation statements)

References 41 publications

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“…It has been reported that dopamine helped regulate Na + /K + -ATPase [ 70 ]. A novel therapy of epilepsy focusing on targeting GABA and dopamine regulation has been discussed [ 71 , 72 ] and, in a study of Parkinson’s disease, dopamine was demonstrated to increase anti-oxidative damage in the blood and delay neurodegeneration [ 73 , 74 ]. Therefore, we hypothesized that when common carp were placed under hypoxic stress, the brain would first activate neuron-related genes, as described above, through the HIF-1 regulation system and activate multiple neuron-related pathways via dopamine-related pathway regulation to avoid damage from hypoxic stress.…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Hung

Chen

Hsu

et al. 2022

Genes

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The common carp is a hypoxia-tolerant fish, and the understanding of its ability to live in low-oxygen environments has been applied to human health issues such as cancer and neuron degeneration. Here, we investigated differential gene expression changes during hypoxia in five common carp organs including the brain, the gill, the head kidney, the liver, and the intestine. Based on RNA sequencing, gene expression changes under hypoxic conditions were detected in over 1800 genes in common carp. The analysis of these genes further revealed that all five organs had high expression-specific properties. According to the results of the GO and KEGG, the pathways involved in the adaptation to hypoxia provided information on responses specific to each organ in low oxygen, such as glucose metabolism and energy usage, cholesterol synthesis, cell cycle, circadian rhythm, and dopamine activation. DisGeNET analysis showed that some human diseases such as cancer, diabetes, epilepsy, metabolism diseases, and social ability disorders were related to hypoxia-regulated genes. Our results suggested that common carp undergo various gene regulations in different organs under hypoxic conditions, and integrative bioinformatics may provide some potential targets for advancing disease research.

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Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Hung

Chen

Hsu

et al. 2022

Genes

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“…HIF‐1 stabilization stimulates tyrosine hydroxylase (TH) expression, 87,88 whereas Hif‐1α knockout in mice reduced this expression 89 . As TH is the main rate‐limiting enzyme in DA production, hypoxia‐ or HIF‐1‐induced TH upregulation augments striatal DA release 13,23,25 and may thereby mitigate parkinsonian symptoms 90,91 . Similarly, the glucagon‐like peptide‐1 (GLP‐1) receptor agonist exenatide might also induce TH 25,92,93 .…”

Section: Targeting the Hypoxia Response Pathway In Pdmentioning

confidence: 99%

“…Furthermore, striatal DA release in mice with different levels of hypoxia is dose dependent, 13 and applying these hypoxic levels to humans is not feasible. In one nonblinded PD trial, a 14‐day intermittent hypoxia protocol in 18 individuals resulted in decreased DOPA (DA precursor) and DA in serum 95 . However, it should be noted that the latter effect is not indicative of the dopaminergic state in the nigrostriatal pathway.…”

Section: Targeting the Hypoxia Response Pathway In Pdmentioning

confidence: 99%

The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?

Janssen Daalen,

Koopman,

Saris

et al. 2023

Movement Disorders

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Parkinson's disease (PD) is a progressive neurodegenerative disorder for which only symptomatic treatments are available. Both preclinical and clinical studies suggest that moderate hypoxia induces evolutionarily conserved adaptive mechanisms that enhance neuronal viability and survival. Therefore, targeting the hypoxia response pathway might provide neuroprotection by ameliorating the deleterious effects of mitochondrial dysfunction and oxidative stress, which underlie neurodegeneration in PD. Here, we review experimental studies regarding the link between PD pathophysiology and neurophysiological adaptations to hypoxia. We highlight the mechanistic differences between the rescuing effects of chronic hypoxia in neurodegeneration and short‐term moderate hypoxia to improve neuronal resilience, termed “hypoxic conditioning”. Moreover, we interpret these preclinical observations regarding the pharmacological targeting of the hypoxia response pathway. Finally, we discuss controversies with respect to the differential effects of hypoxia response pathway activation across the PD spectrum, as well as intervention dosing in hypoxic conditioning and potential harmful effects of such interventions. We recommend that initial clinical studies in PD should focus on the safety, physiological responses, and mechanisms of hypoxic conditioning, as well as on repurposing of existing pharmacological compounds. © 2023 International Parkinson and Movement Disorder Society.

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“…119,139,140 Preclinical studies in rodents further emphasize this potential, for example, in models of Alzheimer's disease 141,142 and Parkinson's disease. 143 Epidemiological studies on the effect of altitude of residence on brain function are conflicting, due in part to socioeconomic confounders. While reduced memory capacities were reported in young Tibetans living at 3650 m vs low altitude residents 144 and subtle impairments in speed of neurocognitive functions were reported in Andean high vs low altitude residents of different age groups, 145 no adverse cognitive effects were found in adolescent Bolivian high altitude (3700 m) residents.…”

Section: Relation Between Cardiovascular Pathologies and Neurodegenerative Diseases At Altitudementioning

confidence: 99%

Impact of High Altitude on Cardiovascular Health: Current Perspectives

Mallet¹,

Burtscher²,

Richalet³

et al. 2021

VHRM

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Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more than 100 million lowlanders visit mountainous areas above 2500 m annually. The interactions between the low barometric pressure and partial pressure of O 2 , climate, individual genetic, lifestyle and socio-economic factors, as well as adaptation and acclimatization processes at high elevations are extremely complex. It is challenging to decipher the effects of these myriad factors on the cardiovascular health in high altitude residents, and even more so in those ascending to high altitudes with or without preexisting diseases. This review aims to interpret epidemiological observations in high-altitude populations; present and discuss cardiovascular responses to acute and subacute high-altitude exposure in general and more specifically in people with preexisting cardiovascular diseases; the relations between cardiovascular pathologies and neurodegenerative diseases at altitude; the effects of high-altitude exercise; and the putative cardioprotective mechanisms of hypobaric hypoxia.

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Intermittent Hypoxia and Experimental Parkinson’s Disease

Cited by 11 publications

References 41 publications

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases

The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?

Impact of High Altitude on Cardiovascular Health: Current Perspectives

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