Intermittent hypoxia is an independent marker of poorer glycaemic control in patients with uncontrolled type 2 diabetes

Torrella, M.; Castells, Ignasi; Giménez-Pérez, Gabriel; Recasens, A; Miquel, Maria Angels de; Simó, Olga; Barbeta, Enric; Sampol, Gabriel

doi:10.1016/j.diabet.2015.01.002

Cited by 29 publications

(21 citation statements)

References 40 publications

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“…The relationship between ODI and glycemic control was mediated by abdominal obesity: ODI was associated with HbA1c levels in the model adjusted for BMI and the no association was observed after adjusting for waist circumference. A similar association between glycemic control and oxygen saturation was reported recently by Torrella et al 12 In that study, 145 patients with T2D underwent overnight pulse oxymetry and intermittent hypoxia was found to be associated with poorer glycemic control after adjusting for obesity, age at onset of diabetes, duration of diabetes, insulin requirement, sleep quality, and depressive mood (odds ratio 2.31, 95 % CI 1.06-5.04). 12 The present study has several limitations.…”

Section: Discussionsupporting

confidence: 86%

“…A similar association between glycemic control and oxygen saturation was reported recently by Torrella et al 12 In that study, 145 patients with T2D underwent overnight pulse oxymetry and intermittent hypoxia was found to be associated with poorer glycemic control after adjusting for obesity, age at onset of diabetes, duration of diabetes, insulin requirement, sleep quality, and depressive mood (odds ratio 2.31, 95 % CI 1.06-5.04). 12 The present study has several limitations. First, the evaluation of sleep apnea was performed using ApneaLink with oximetry, a portable device, instead of polysomnography.…”

Section: Discussionsupporting

confidence: 86%

“…Data regarding the effect of untreated SAS on glucose control in patients with T2D is still limited and results are conflicting . Among the 10 studies identified in the literature assessing the association between SAS or suspected SAS and glycemic control in patients with T2D, five reported a positive association, four reported no association, and one reported an association only in patients with untreated diabetes …”

Section: Introductionmentioning

confidence: 99%

“…11 Data regarding the effect of untreated SAS on glucose control in patients with T2D is still limited and results are conflicting. 4,5,[12][13][14][15][16][17][18][19][20] Among the 10 studies identified in the literature assessing the association between SAS or suspected SAS and glycemic control in patients with T2D, five reported a positive association, 4,5,[12][13][14] four reported no association, [16][17][18][19] and one reported an association only in patients with untreated diabetes. 20 The aim of the present study was to assess the effect of untreated sleep apnea on glycemic control, as evaluated by HbA1c, in patients with T2D.…”

Section: Introductionmentioning

confidence: 99%

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HbA1c levels are associated with severity of hypoxemia and not with apnea hypopnea index in patients with type 2 diabetes: Results from a cross‐sectional study

Rusu

Bala

Crăciun

et al. 2016

Journal of Diabetes

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HbA1c levels are associated with severity of hypoxemia and not with apnea hypopnea index in patients with type 2 diabetes: Results from a cross‐sectional study

Rusu

Bala

Crăciun

et al. 2016

Journal of Diabetes

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“…Chronic intermittent hypoxia (CIH), characterized by periods of low oxygen, is the most common physiological characteristic of OSAHS. Diabetes mellitus (DM), particularly type Ⅱ DM (T2DM), is one of the risk factors of OSAHS (9)(10)(11). However, data on the association between DM and CIH are scarce.…”

Section: Introductionmentioning

confidence: 99%

Effect of garlic on rats with chronic intermittent hypoxia combined with diabetes mellitus

Peng

2018

Mol Med Report

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The present study investigated the effect of garlic (G) on serum, liver, renal and cerebral parameters of rats with chronic intermittent hypoxia (CIH) combined with diabetes mellitus (DM). A total of 32 rats were divided into eight groups, with 4 rats/group. A total of three models were established, including CIH, DM and CIH‑DM, and an additional healthy control (C) group. Rats in C‑G, CIH‑G, DM‑G and CIH‑DM‑G groups were injected with a G extract daily. Serum, liver, renal and cerebral parameters were detected. The results demonstrated that the rats' weight increased gradually, but at a slower rate in the CIH, DM and CIH‑DM groups compared with the healthy rats. Blood glucose increased in the DM and CIH‑DM groups compared with the healthy control group, while insulin level increased in the CIH group, but decreased in the DM and CIH‑DM groups, resulting in increased homeostatic model assessment of insulin resistance (HOMA‑IR) value in the CIH group, compared with healthy controls. Serum thiobarbituric acid reactive substances (TBARS), glutathione S‑transferase (GST), uric acid (UA), urine protein (UP), total cholesterol (TC), triglycerides (TG), total lipids (TL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and acid phosphatase (ACP) increased in the CIH, DM and CIH‑DM groups, while albumin and superoxide dismutase (SOD) decreased in all model groups compared with healthy controls. Nitric oxide (NO) increased in the DM and CIH‑DM groups but decreased in the CIH group, compared with the control group. Glutathione peroxidase (GSH‑Px) increased in the CIH group but decreased in the DM and CIH‑DM groups, compared with the control group. Glutathione reductase (GR) increased in the DM group but decreased in the CIH and CIH‑DM groups, compared with the control group. Liver TBARS and GST increased, while AST, ALT, LDH, ALP, ACP, catalase activity (CAT) and SOD decreased in the CIH, DM and CIH‑DM groups, compared with the control group. Liver GSH‑Px decreased in the DM and CIH‑DM groups, compared with the control group. Renal TBARS in the DM and CIH‑DM groups increased compared with the control group. Renal GST increased while CAT and SOD decreased in the CIH, DM and CIH‑DM groups, compared with the control group. Cerebral TBARS increased in the CIH, DM and CIH‑DM groups and LDH increased in the DM and CIH‑DM groups, compared with the control group. Cerebral LDH in CIH decreased compared with the control group. G treatment improved weight gain, blood insulin and HOMA‑IR in the DM and CIH‑DM groups, reduced blood glucose in the DM and CIH‑DM groups, and insulin and HOMA‑IR in the CIH group, compared with the respective G‑untreated groups. G treatment increased serum SOD in CIH‑G, DM‑G and CIH‑DM‑G groups, GSH‑Px and albumin in the DM‑G and CIH‑DM‑G groups, and GR in the DM‑G group, compared with the respective G‑untreated groups. G treatment decreased serum TBARS, UA, UP, TC, TG, TL, AST, ALT, LDH and ACP in the CIH‑G, DM‑G and CIH‑DM‑G groups; N...

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Obesity and Obstructive Sleep Apnea

Bonsignore

2021

Handbook of Experimental Pharmacology

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Intermittent hypoxia is an independent marker of poorer glycaemic control in patients with uncontrolled type 2 diabetes

Cited by 29 publications

References 40 publications

HbA1c levels are associated with severity of hypoxemia and not with apnea hypopnea index in patients with type 2 diabetes: Results from a cross‐sectional study

HbA1c levels are associated with severity of hypoxemia and not with apnea hypopnea index in patients with type 2 diabetes: Results from a cross‐sectional study

Effect of garlic on rats with chronic intermittent hypoxia combined with diabetes mellitus

Obesity and Obstructive Sleep Apnea

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