Intermittent injection of Methylprednisolone Sodium Succinate in the treatment of Cervical Spinal Cord injury complicated with incomplete paraplegia

Abstract

Objective: To evaluate the clinical efficacy and safety of intermittent injection of methylprednisolone sodium succinate in the treatment of cervical spinal cord injury complicated with incomplete paraplegia.
 Methods: Seventy-eight patients with cervical spinal cord injury complicated with incomplete paraplegia who were admitted between August 2016 and December 2017 were enrolled and grouped into an observation group and a control group using random number table, 39 in each group. Patients in the control group were given vertebral body decompression and bone grafting and internal fixation according to the severity of spinal cord compression, while patients in the observation group were treated by methylprednisolone sodium succinate in addition to the same treatment as the control group. The clinical efficacy and medicine associated adverse reactions were compared between the two groups.
 Results: The cure rate of the observation group was significantly higher than that of the control group (46.2% (18/39) vs. 20.5% (8/39)). After the treatment, the Japanese Orthopaedic Association (JOA) score and American Spinal Cord Injury Association (ASIA) score of the two groups after treatment were significantly higher compared to before treatment, and the scores of the observation group were much higher than those of the control group (P<0.05). The incidence of adverse reactions of the observation and control groups was 15.4% and 17.9% respectively, and the difference was not statistically significant (P>0.05).
 Conclusion: Intermittent injection of methylprednisolone sodium succinate has definite efficacy in treating cervical spinal cord injury complicated with incomplete paraplegia, with a low incidence of adverse reactions; hence it is worth promotion.
 How to cite this:Wang W, Zuo B, Liu H, Cui L. Intermittent injection of Methylprednisolone Sodium Succinate in the treatment of Cervical Spinal Cord injury complicated with incomplete paraplegia. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.211
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The safety and efficacy of steroid treatment for acute spinal cord injury: A Systematic Review and meta-analysis

“…A total of 12 studies met the inclusion criteria and were incorporated into the meta-analysis. These included five randomized controlled trials (RCTs) [4,8,16,17,18] and seven observational studies (OBSs) [19,20,21,22,23,24,25]. The characteristics of the twelve studies are shown in Table 1.…”

“…The included studies were conducted in Asia, North America, and Europe. Assessment of the quality of the randomized trials using the risk of bias assessment tool yielded three studies with low bias [4,16,18] and two studies with high bias (Table 1) [8,17]. A total of four studies (2 RCTs and 2 OBSs) had short term follow-up [8,17,19,24].…”

“…Assessment of the quality of the randomized trials using the risk of bias assessment tool yielded three studies with low bias [4,16,18] and two studies with high bias (Table 1) [8,17]. A total of four studies (2 RCTs and 2 OBSs) had short term follow-up [8,17,19,24]. Assessment of study quality of the OBSs using the NOS score yielded an average of 6.86 ranging from 6 to 9.…”

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Application of stem cells and chitosan in the repair of spinal cord injury

“…The pathophysiologic mechanism of SCI is complicated and includes the loss of neurons and glial cells, degeneration of extracellular matrix architecture and destruction of the neural circuit at the lesion site (Kumar et al, 2015; Chen et al, 2018a). Current strategies to cure SCI include surgical decompression (Jug et al, 2015; Liu et al, 2016) and pharmacotherapy (Wang et al, 2019) as well as focus on the restoration of nerve function by enhancing the survival of neurons after injury and promotion of axon regeneration via the injury site. Notably, surgical decompression and methylprednisolone could only remove the initial pathogen and preclude secondary damage of SCI.…”