Internal and external flavonoids from the leaves of Japanese Chrysanthemum species (Asteraceae)

Uehara, Ayumi; Nakata, Masashi; Kitajima, Junichi; Iwashina, Tsukasa

doi:10.1016/j.bse.2011.12.020

Cited by 19 publications

(27 citation statements)

References 21 publications

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“…Flavonoids are improtant phytochemicals characterized by a common benzo-γ-pyrone chemical structure and found widely in different plants, especially in genus Citrus (Nogata et al, 2006;Rutaceae et al, 2006;Uehara et al, 2012). Flavonoids exhibit various beneficial properties in a multitude of disease states, including cardiovascular disease, neurodegenerative disorders and cancer (Gao et al, 2012;Master et al, 2012;McCullough et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

Wang¹,

Wang²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Luteolin is a plant flavonoid which exhibits anti-oxidative, anti-inflammatory and anti-tumor effects. However, the antiproliferative potential of luteolin is not fully understood. In this study, we investigated the effect of luteolin on cell cycling and apoptosis in human esophageal squamous carcinoma cell line Eca109 cells. MTT assays showed that luteolin had obvious cytotoxicity on Eca109 with an IC 50 of 70.7±1.72μM at 24h. Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose-and time-dependent manner. as assessed by FCM. Luteolin induced apoptosis of Eca109 cells was demonstrated by AO/EB staining assay and annexin V-FITC/PI staining. Moreover, luteolin downregulated the expression of cyclin D1, survivin and c-myc, and it also upregulated the expression of p53, in line with the fact that luteolin was able to inhibit Eca109 cell proliferation.

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Section: Introductionmentioning

confidence: 99%

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

Wang¹,

Wang²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Several flavonoids have been isolated from some Chrysanthemum in China (12) and Japan (13). Chrysanthemum zawadskii var.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

Kim

Lee

Choi

et al. 2015

Food Sci Biotechnol

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This study was conducted to compare flavonoids and anti-inflammatory effects in Korean Chrysanthemum species. Leaf samples were identified using HPLC/MS with five flavonoids: luteolin-7-O-rutinoside, luteolin-7-Oglucoside, apigenin-7-O-glucoside, apigenin, and acacetin-7-O-rutinoside. Leaf extracts from four taxa dose-dependently suppressed LPS-stimulated NO production significantly (p<0.05) inhibited production of LPS-induced PGE 2 compared with controls. The extracts reduced the LPS-induced expressions of inducible NO synthase and cyclooxygenase-2 and inhibited LPS-induced tumor necrosis factor-α and interleukin-6 production for anti-inflammatory effects.

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“…(1) Purification and NMR identification of the flavonoids were described by Spindola (2015), and all the compounds were described to occur in D. grandiflorum (Lin and Harnly, 2010;Uehara et al, 2012). Table 1 shows the identified compounds for fatty and caffeic acids, as well as flavonoids of D. grandiflorum methanol extract, as identified from ESI(-)-FT-ICR MS data.…”

Section: Phytochemical Analysismentioning

confidence: 99%

Dendranthema grandiflorum, a hybrid ornamental plant, is a source of larvicidal compounds against Aedes aegypti larvae

Spindola

Simas

Santos

et al. 2016

Revista Brasileira de Farmacognosia

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a b s t r a c tIn hybrid cultivated form, Dendranthema grandiflorum (Ramat.) Kitam., Asteraceae, flowers (Chrysanthemum morifolium Ramat.) were utilized in the production of extracts, which were analyzed for larvicidal activity against Aedes aegypti third instar larvae. Methanol and dichloromethane extracts showed LC 50 values of 5.02 and 5.93 ppm, respectively. Using GC-MS, phytochemical analyses of the dichloromethane extract showed the presence of triterpenoids and fatty acids, while flavonoids and caffeoylquinic acids were shown to occur in the methanol extract by ESI Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (ESI-FT-ICR-MS). Triterpenoids and fatty acids are well known insecticidal compounds. From this study, it can be concluded that D. grandiflorum grown for floriculture, as an agribusiness, can have additional applications as raw material for the production of insecticidal products.

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Internal and external flavonoids from the leaves of Japanese Chrysanthemum species (Asteraceae)

Cited by 19 publications

References 21 publications

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

Dendranthema grandiflorum, a hybrid ornamental plant, is a source of larvicidal compounds against Aedes aegypti larvae

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