Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions

Abstract

In a series of our recent studies, stress was found to induce simultaneously hypothermia and hyperglycemia. These conditions are beneficial to obtain prompt force which depends on the glycolysis pathway and to escape emergency. Since we have noticed that such conditions resemble the internal environment seen in some cancer patients, it was investigated whether such conditions were accompanied with other patients. We selected patients with early and advanced cancer. Body temperature and other parameters including blood gas contents were examined. A difference was seen in body temperature, namely, many patients showed hypothermia, irrespective of cancer stages. Further characterization of other parameters showed that hypothermia and hyperglycemia existed in many patients. They had immunosuppressive state and anemia. Blood gas analysis showed that oxygen contents were low and carbon dioxide contents were high in patients. These results suggest a possibility that the internal environment seen in patients is responsible to induce onset of disease and to maintain their cell growth, because cancer cells have an energy system of predominant glycolysis. Although hypothermia, hypoxia and hyperglycemia are important to activate the glycolysis pathway and to escape from emergency, such responses suppress the mitochondrial pathway for long span and may result in carcinogenesis.

The effects of application of an ancient type of acupuncture needle on body temperature, immune function and the autonomic nerve system

“…Fresh venous blood was obtained before and after the DZ application for the measurement of PO 2 , SO 2 , PCO 2 and hemoglobin, using i-STAT 300 F (i-STAT Corporation, East Windsor, NJ, USA) as previously described [4][5][6][7]. WBCs were measured using a hemocytometer and the May-Grünwald Giemsa stain method.…”

A Medical Hypothesis: Excessive Adaptation Results in Relative Hypothermia and Lymphocytopenia, as Seen in Carnivorous Aquatic Mammals

“…This hypothesis may provide insights into our own health. Hypothermia and lymphocytopenia, which are features of aquatic mammals with stressful evolutionary histories, are also characteristics of the internal environment of cancer patients [5] [6]. In Japanese people, the average axillary body temperature had decreased from 36.8˚C to 36.2˚C -36.3˚C during the last five decades in conjunction with an enormous change in lifestyle.…”

“…Adaptive responses are often induced by stress and we have previously reported an adaptive glycolytic response to adverse internal conditions [5] [6]. In addition, we have shown that both hypothermia and lymphocytopenia are induced by stress [3] [4].…”

“…We also suggest that an excessive stress may lead to a shift of glucose metabolism from glycolysis pathway to the mitochondria pathways [6]. It may be considered that a drastic change in lifestyle can induce.…”

The Association between Self-Monitored Reproductive Parameters, Pregnancy Outcomes and Acupuncture Treatment

“…For example, one of our patients, who was observed in this study, had a miscarriage soon after exercising in a cold water pool, possibly due to a cold stress-induced imbalance in autonomic nerve status (excess sympathetic nerve dominance) via hypothermia. Accordingly, our patients were advised to avoid stressful situations (e.g., overwork) and the use of hot-water bottles while sleeping, and advised to practice deep breathing several times a day to promote relax [14]. Psychological advice from a specialist, as well as medical support, may be beneficial for pregnant women.…”