1998
DOI: 10.1002/(sici)1097-0142(19981101)83:9<1894::aid-cncr4>3.3.co;2-f
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Internal radiation therapy for patients with primary or metastatic hepatic cancer

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Cited by 23 publications
(26 citation statements)
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“…We can assure the authors of a similar cell killing effect as observed with 131 I-Lipiodol if they try to increase the NaI ( 131 I) concentration to 250 µCi ml -1 . From our own experience in treating 26 patients with hepatocellular carcinoma using 131 I-Lipiodol (Leung et al, 1994) and the results of the other 12 clinical series of hepatic cancer treated with the same agent that have recently been reviewed by us (Ho et al, 1998) we agree with the authors that the response is highly variable and may partly depend on local pharmacokinetics. The other important factor of course is the radio-sensitivity of the tumour cells.…”
supporting
confidence: 59%
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“…We can assure the authors of a similar cell killing effect as observed with 131 I-Lipiodol if they try to increase the NaI ( 131 I) concentration to 250 µCi ml -1 . From our own experience in treating 26 patients with hepatocellular carcinoma using 131 I-Lipiodol (Leung et al, 1994) and the results of the other 12 clinical series of hepatic cancer treated with the same agent that have recently been reviewed by us (Ho et al, 1998) we agree with the authors that the response is highly variable and may partly depend on local pharmacokinetics. The other important factor of course is the radio-sensitivity of the tumour cells.…”
supporting
confidence: 59%
“…The other important factor of course is the radio-sensitivity of the tumour cells. As we have pointed out in our review article (Ho et al, 1998) for a lesion to be completely destroyed by 131 I-Lipiodol, it needs to uptake the agent in such a way that every cancer cell lies within 2.4 mm from the radioactive oil, which is the maximum penetration of the beta-radiation from 131 I. 131 I-Lipiodol could hardly concentrate in hypovascular or necrotic tumours and therefore their responses are poor.…”
mentioning
confidence: 99%
“…Internal radiation aims at improving the selectivity of the radiation by targeting the radioisotopes to the tumour cells. To achieve this targeting, the therapeutic radiopharmaceuticals such as 90Y microspheres or 131I-Lipiodol may be administered via the hepatic artery 19 .…”
Section: Basics Of Interventional Nuclear Medicine Therapies Of Hcc Wmentioning
confidence: 99%
“…Based on the findings of previous reports, we administered 2-20 mCi of I-131-labelled Suicide-gene therapy for HCC Y Kawashita et al lipiodol to each animal in a total volume of 100 ml, diluted with cold lipiodol 24 h after transfection. 41 Subsequently, 48 and 72 h after transfection, the tumors, livers and lungs of the animals were excised and immersed in 1200 ml of 3 Â reporter lysis buffer, and then were cut with sterile scissors. The mixture was transferred to a 15 ml falcon tube and homogenized using a sonicator for 5-10 min, followed by centrifugation at 3000 r.p.m.…”
Section: In Vivo Luciferase Assaymentioning
confidence: 99%