Internal Scaffold Architecture Designs using Lindenmayer Systems

Starly, Binil; Sun, Wei

doi:10.1080/16864360.2007.10738559

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…Figure 1 shows and outline of the application potential of the DMM. This fabrication system eliminates the limitations of con ventional photolithography and enables the end user with the capa bilities to develop advantageous models within minutes [18,24]. The fabrication of microdevices/constructs can be a lengthy, costly, and labor-some process.…”

Section: Introductionmentioning

confidence: 98%

Fabrication of Biological Microfluidics Using a Digital Microfabrication System

Hamid

Wang

Zhao

et al. 2014

Journal of Manufacturing Science and Engineering

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Micro-electromechanical systems (MEMS) technologies illustrate the potential for many applications in the field of tissue engineering, regenerative medicine, and life sciences. The fabrication of tissue models integrates the multidisciplinary field o f life sciences and engineering. Presently, monolayer cell cultures are frequently used to investigate poten tial anticancer agents. These monolayer cultures give limited feedback on the effects of the micro-environment. A micro-environment, which mimics that o f the target tissue, will eliminate the limitations of the traditional mainstays of tissue research. The fabrication o f such micro-environment requires a thorough investigation of the actual target organ, and or tissue. Conventional MEMS technologies are developed for the fabrication of inte grated circuits on silicon wafers. Conventional MEMS technologies are very expensive and are not developed for biological applications. The digital micromirroring microfab rication (DMM) system eliminates the need for an expensive chrome mask by incorporat ing a dynamic mask-less fabrication technique. The DMM is designed to utilize its digital micromirrors to fabricate of biological devices. This digital microfabrication system pro vides a platform for the fabrication of economic biological microfluidics that is specifi cally designed to mimic the in vivo conditions of the tissue of interest. Investigations portrayed in this paper demonstrate the DMM capabilities to develop biological microfluidics. Though the applications of the DMM are extensive, the simple sinusoidal microfluidic characterized in this paper illustrates the DMM capabilities to develop biological microfluidic chips.

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Section: Introductionmentioning

confidence: 98%

Fabrication of Biological Microfluidics Using a Digital Microfabrication System

Hamid

Wang

Zhao

et al. 2014

Journal of Manufacturing Science and Engineering

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“…Due to the restricting features of extrusion‐based techniques, nonintersecting continuous curves are particularly attractive. This includes fractal space‐filling curves that can be generated using a simple pattern as a starting point, which then grow through the recursive application of a certain set of mathematical rules …”

Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review

Yousefi

Hoque

Prasad³

et al. 2014

J. Biomed. Mater. Res.

176

157

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The repair of osteochondral defects requires a tissue engineering approach that aims at mimicking the physiological properties and structure of two different tissues (cartilage and bone) using specifically designed scaffold-cell constructs. Biphasic and triphasic approaches utilize two or three different architectures, materials, or composites to produce a multilayered construct. This article gives an overview of some of the current strategies in multiphasic/gradient-based scaffold architectures and compositions for tissue engineering of osteochondral defects. In addition, the application of finite element analysis (FEA) in scaffold design and simulation of in vitro and in vivo cell growth outcomes has been briefly covered. FEA-based approaches can potentially be coupled with computer-assisted fabrication systems for controlled deposition and additive manufacturing of the simulated patterns. Finally, a summary of the existing challenges associated with the repair of osteochondral defects as well as some recommendations for future directions have been brought up in the concluding section of this article.

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“…Chan and Hui [4] have developed a method to automate the surface pattern generation process using Lindenmayer-system (an approach that also creates IFS fractals) and genetic algorithms. Sun and Starly [33] have developed a method to generate shapes having scaffolds (internally networked channels) using Lindenmayer-system for bio-CAD and rapid prototyping.…”

Section: Related Workmentioning

confidence: 99%

A Hybrid Approach of Dynamic Programming and Genetic Algorithm for Multi-criteria Optimization on Sustainable Architecture design

Chang¹,

Shih²

2014

Computer-Aided Design and Applications

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This study deals with the design for manufacturing (DFM) of fractals created by a random walk called iterated function system (IFS). In particular, the DFM of an IFS-created fractal called Barnsley's fern-leaf is considered. The IFS dedicated for creating virtual models of a fern-leaf uses a set of four strictlycontracting affine mappings in the onto manner. The interactions among these mappings are studied in detail in order to identify some data structures. Based on the identified data structures, a DFM procedure is proposed. In the proposed DFM procedure, three out of the four mappings are employed in both the onto and one-to-one manner. The proposed DFM procedure is applied to the redesign of the shape (fern-leaf). Physical models of the redesigned fern-leaf are manufactured using both additive and subtractive manufacturing technologies (3-D printing and milling). The factors affecting accuracy of the physical models are also described. Although this study is limited to the shape of the fern-leaf, other IFS-created shapes can be redesigned using the proposed DFM procedure. Nevertheless, this study sheds some light on our understanding of how to develop more accurate physical models of IFS-created fractals.

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Internal Scaffold Architecture Designs using Lindenmayer Systems

Cited by 16 publications

References 22 publications

Fabrication of Biological Microfluidics Using a Digital Microfabrication System

Fabrication of Biological Microfluidics Using a Digital Microfabrication System

Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review

A Hybrid Approach of Dynamic Programming and Genetic Algorithm for Multi-criteria Optimization on Sustainable Architecture design

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