Internal standards in inductively coupled plasma mass spectrometry using kinetic energy discrimination and dynamic reaction cells

Abstract

ICP-MS is a sensitive element analysis technique used for analyzing several different sample types.

Evaluation of internal standards for inductively coupled plasma–mass spectrometric analysis of arsenic in soils

“…An important shortcoming of this approach is not accounting for the possible charged polyatomic, ArCl + , with the same mass as 75 As. Further screening of ISs or the use of a collision/reaction cell might be required (Korvela et al., 2018), although the presence of elevated concentrations of rare earth elements can create further complications (Sugiyama, 2021).…”

Strategies to overcome interferences in elemental and isotopic geochemical analysis by quadrupole inductively coupled plasma mass spectrometry: A critical evaluation of the recent developments

“…Loss of analytical sensitivity, its inability to remove major interferences, and its applicability in cases where the interfering ion has a notably larger cross‐sectional area than the analyte ion are some of the major drawbacks of this technique. In addition, the choice of internal standards can become difficult for certain elements such as Zn, As, and Se during the use of collision/reaction cells with KED, as pointed out by Korvela et al 159 In another example, Sugiyama 160 used hydrogen as an effective collision cell gas for the attenuation of M ++ interferences with KED. The optimized method used low kinetic energy collision cell conditions to reduce REE ++ (and polyatomic ion) interferences on As + and Se + in samples containing high levels of REE.…”

An evaluation of M2+ interference correction approaches associated with As and Se in ICP-MS using a multi-day dataset along with ICP-MS/MS/HR-ICP-MS based analysis and hierarchical modeling as a means of assessing bias in fortified drinking waters and single component matrices

“…There are a number of different approaches to estimate and apply M 2+ correction factors in ICP-MS. 3,10,[24][25][26] The approaches applied in this manuscript will involve using internal standards to correct for the dri in the M 2+ correction factor within an analysis batch. Proper internal standard selection for M 1+ analytes has been the subject of a number of papers [27][28][29][30][31][32][33][34][35][36] with some data supporting the use of internal standards that are close in mass and other data indicating the importance of matching the ionization potential. Tan and Horlick 27 published one of the original papers that addressed mass dependent matrix effects in ICP-MS. Olesik et al 33 revisited this in 2017 aer having considerable experience using only a single internal standard with a modern instrument design.…”