Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine

Arrué, Lily; Ratjen, Lars

doi:10.1002/cmdc.201700621

Cited by 13 publications

(7 citation statements)

References 107 publications

(174 reference statements)

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“…If the nanovalve is more sensitive to external stimuli, it has a higher value for development. Moreover, isomerization of azobenzene, tetra-ortho-methoxy-substituted azobenzene, and arylazopyrazoles have different response wavelengths . Therefore, nanovalves based on different response wavelength can be used to control drug release in different depths of tissues.…”

Section: Discussionmentioning

confidence: 99%

Controlled Drug Release from Cyclodextrin-Gated Mesoporous Silica Nanoparticles Based on Switchable Host–Guest Interactions

Zheng

et al. 2018

Bioconjugate Chem.

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With the development of materials science and pharmaceutics, the application of mesoporous silica nanoparticles with a gated switch in the field of drug delivery has attracted much attention in the past decades. Cyclodextrins (CD) as promising gated materials have become a new area of interest in recent years due to their properties of self-assembly and function of host-guest interaction. CD is one kind of extensively studied host molecules and the host-guest interactions with different guest molecules can respond to different signals, and thus can be applied as intelligent gated switches for smart drug carriers. Switchable gatekeepers based on CD hosts with different guest molecules (such as benzimidazole, azobenzene, and ferrocene) respond to different stimuli modes (such as pH, light, and redox) that change the host-guest interactions and trigger drug release. The different structural features, mechanisms of action, and potent applications of these switchable gatekeepers are discussed. In addition, some personal perspectives and challenge on this field are presented.

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Section: Discussionmentioning

confidence: 99%

Controlled Drug Release from Cyclodextrin-Gated Mesoporous Silica Nanoparticles Based on Switchable Host–Guest Interactions

Zheng

et al. 2018

Bioconjugate Chem.

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“…The term “photopharmacology” is used in reference to bioactive molecular systems that undergo reversible photochemical transformations that alter their pharmacokinetic or pharmacodynamic properties. This is a relatively new concept but one that has attracted considerable attention and has therefore been reviewed several times in recent years. ,,− Consequently, we present only a few representative examples here.…”

Section: Photoactivation and Photodeactivation Of Drugs: Photopharmac...mentioning

confidence: 99%

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

et al. 2020

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Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged or photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species of interest. Recent years have seen the development of PPGs activatable by biologically and chemically benign visible and near-infrared (NIR) light. These long-wavelength-absorbing moieties expand the applicability of this powerful method and its accessibility to non-specialist users. This review comprehensively covers organic and transition metal-containing photoactivatable compounds (complexes) that absorb in the visible- and NIR-range to release various leaving groups and gasotransmitters (carbon monoxide, nitric oxide, and hydrogen sulfide). The text also covers visible- and NIR-light-induced photosensitized release using molecular sensitizers, quantum dots, and upconversion and second-harmonic nanoparticles, as well as release via photodynamic (photooxygenation by singlet oxygen) and photothermal effects. Release from photoactivatable polymers, micelles, vesicles, and photoswitches, along with the related emerging field of photopharmacology, is discussed at the end of the review.

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“…This process is commonly mediated by endocytosis for reduced side effects and optimized cargo delivery, impacting on the effectiveness and efficiency of the therapeutic regimens [235,236]. Phototriggering nanocarriers provide not only spatiotemporal control of cargo delivery [237], activating and controlling the kinetics of the related processes [238], but also reasonable control for fluorescence imaging [239] and photodynamic therapy [240], among other applications (Figure 1(Ae)) [241]. Nanocarriers are synthesized with free functional groups with a positive or negative net charge, porosity, and adsorption characteristics on their surface for functionalization, targeting biomolecules via covalent linking, adsorption, and π-π interaction strategies, promoting specific interactions with the target cells [242][243][244].…”

Section: Functionalization Of Phototriggered Nanocarriers For Targeting Cellsmentioning

confidence: 99%

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

Mena-Giraldo

Orozco

2021

Polymers

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Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo. Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (PC) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target. PCs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect. Micromotors based on PCs offer an accelerated cargo–medium interaction for biomedical, environmental, and many other applications. This review collects the recent achievements in PC development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (UV) and near-infrared (NIR) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy. We emphasize the challenges of positioning PCs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.

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Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine

Cited by 13 publications

References 107 publications

Controlled Drug Release from Cyclodextrin-Gated Mesoporous Silica Nanoparticles Based on Switchable Host–Guest Interactions

Controlled Drug Release from Cyclodextrin-Gated Mesoporous Silica Nanoparticles Based on Switchable Host–Guest Interactions

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery

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