Internal Thoracic Lymphadenopathy in Breast Cancer

Cahoon, Ashley R.; Smith, Benjamin D.; Yang, Wei Tse

doi:10.1148/rg.2017160166

Cited by 12 publications

(13 citation statements)

References 41 publications

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“…Malignancies affecting lymph nodes account for secondary localisation of thoracic or extrathoracic malignancies (metastasis of lung cancer, digestive cancer or gynaecological malignancies) or primary nodal lesions (haematological malignancies) [87][88][89].…”

Section: Malignant Diseasesmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, which need to be integrated with imaging and laboratory findings. In addition, the location of the mediastinal lesion is fundamental; indeed, we propose to illustrate mediastinal diseases based on the compartment of origin. We consider that this structured approach may serve as hint to the diagnostic modalities and management of mediastinal diseases. In this review, we present primary mediastinal tumours in the evolving context of new diagnostic and therapeutic tools, with recently described entities, based on our own experience with >900 cases encountered in the past 10 years.

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Section: Malignant Diseasesmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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“…The prognostic role of regional LAP in several malignancies has been considered in previous studies (30,31) and reviews (32). Cahoon et al (32) indicated that understaging of internal thoracic LAP in patients with breast cancer significantly impacted patient outcomes.…”

Section: Discussionmentioning

confidence: 99%

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

Wang¹,

Pan²,

Zhu³

et al. 2021

Quant Imaging Med Surg

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Background: To assess the value of characteristic computed tomography (CT) findings in predicting the survival of patients with pulmonary B-cell non-Hodgkin's lymphoma (NHL).Methods: Eighty-four patients who were histopathologically confirmed with pulmonary B-cell NHL between 2004 and 2018 were retrospectively enrolled. All patients underwent chest CT scan at the time of initial diagnosis in our hospital. Characteristic CT findings and clinicopathological features of the patients were analyzed, and Cox regression models were used to determine the relationship of CT findings with overall survival (OS) and progression-free survival (PFS).Results: Air bronchogram occurred more frequently in patients with early-stage disease, primary pulmonary lymphoma (PPL) and the indolent histological type of lymphoma than in patients with advancedstage disease, secondary pulmonary lymphoma (SPL), and the aggressive histological type (all P<0.05). The halo sign was observed most in the SPL group (19/48, 40%; P=0.004), while the presence of cross-lobe sign was higher in patients with PPL (13/36, 36%; P=0.010). Pleural involvement and hilar/mediastinal lymphadenopathy were observed more in patients with SPL and the aggressive histological type (33/48 and 27/48; 31/46 and 26/46, respectively; all P<0.05). Survival analyses showed that the number of lung lesions, cross-lobe sign, and pleural involvement were independent prognostic factors for PFS, while the halo sign and pleural involvement were significantly correlated with OS (all P<0.05). More aggressive, advanced-stage cases and male patients showed worse outcomes. Conclusions:The halo sign and pleural involvement are independent prognostic factors for OS, while the number of lung lesions, cross-lobe sign, and pleural involvement are correlated with PFS.

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“…The IMN is situated in the parasternal region surrounded by the interpectoral muscle, fibrofatty tissue, and the internal mammary vessels [10]. As the IMN is located in narrow intercostal spaces adjacent to the internal mammary vessels, it is difficult to perform a biopsy the IMN.…”

Section: Discussionmentioning

confidence: 99%

Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer

et al. 2020

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Background: This study aimed to determine the optimal radiotherapy (RT) regimen for patients with clinical metastasis to the internal mammary lymph node (cIMN+) from breast cancer. Methods: We retrospectively reviewed the medical records of 84 patients with cIMN+ breast cancer treated with curative surgery, taxane-based chemotherapy, and postoperative RT between January 2009 and December 2014. Postoperative RT was administered to the whole breast or chest wall using 50 Gy in 2 Gy fractions. Boost RT to the internal mammary lymph node (IMN) was administered at the physician's discretion. We categorized patients into two groups according to the IMN dose as follows: low-dose IMN RT (50.0-63.5 Gy) and high-dose IMN RT (63.6-70.4 Gy). Results: After a median follow-up of 58 months (range, 12-111 months), IMN recurrence was observed in 2 patients (2.4%), and all IMN recurrences developed simultaneously with distant metastases. The 5-year locoregional recurrence-free survival, disease-free survival (DFS), and overall survival rates were 89.1, 72.0, and 81.2%, respectively. The triple-negative subtype, IMN size ≥1.0 cm, old age, and low-dose IMN were significantly associated with poor DFS. Among the patients with IMN size ≥1.0 cm, the 5-year DFS was significantly higher in those treated with high-dose IMN RT than in those treated with low-dose IMN RT (69.3% vs. 33.3%, p = 0.019). Conclusions: IMN RT without IMN dissection resulted in favorable outcomes in cIMN+ breast cancer. For patients with a large IMN, a higher IMN radiation dose might be needed for disease control.

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Internal Thoracic Lymphadenopathy in Breast Cancer

Cited by 12 publications

References 41 publications

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

Optimal radiotherapy for patients with internal mammary lymph node metastasis from breast cancer

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