International Collation of Traditional and Folk Medicine

Kimura, Takeatsu; But, Paul Pui‐Hay; Guo, Ji-Xian; Sung, Chung Ki

doi:10.1142/3041

Cited by 45 publications

(31 citation statements)

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“…Leaves of Eriobotrya japonica (LEJ) Lindl (Rosaceae) have been used as traditional medicines for lung and stomach diseases and have been found to be effective in chronic bronchitis, inflammation, asthma, low back pain and tumor. [1][2][3]4 Studies have demonstrated that LEJ has anti-inflammatory activity in a 12-O-tetradecanoylphorbol-13-acetate induced inflammation model. These reports strongly suggest that LEJ can be used as an anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

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Background: In the present work we determined phenolic and flavonoids content of Eriobotrya japonica leaves extracts and fractions and their antioxidant and anti-inflammatory properties. Objectives: To evaluate the inhibition of inflammatory PLA2 and antioxidant effects of extracts and fractions from Eriobotrya japonica leaves Methods: Antioxidant activity was evaluated with DPPH radical scavenging assay and anti-inflammatory effect of fractions was measured by their inhibition potency on the human pro-inflammatory phospholipase A2 (group IIA). Results: The EtOH/EtOAc 2:1 extract exhibited a potent inhibition of the hG-IIA with an IC50 values of 8 µg/ml. It also shows an antioxidant activity measured on DPPH with an IC50 of 42 µg/ml. Fractionation shows that CH2Cl2/MeOH 0:1 fraction was the rich one on flavonoids compounds (4.3 mg/g dry weight) and demonstrates a high antioxidant activity with an IC50 of 12 µg/ml. The anti-inflammatory evaluation demonstrates that the same fraction was the best one to inhibit the pro-inflammatory phospholipase A2 group IIA with an IC50 of 4 µg/ml. Conclusion: Study conducted on Eriobotrya japonica shows that CH2Cl2/MeOH 0:1 fraction inhibits efficiently the hG-IIA phospholipase.which is considered as pro-inflammatory enzyme.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

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“…The roots of P. multiflorum have been used in traditional medicine for constipation, hyperlipemia, backache, premature graying of hair, hypercholesterolemia, neurasthenia, and weakness of the body in Oriental countries (Kimura et al, 1996). Earlier investigations on the chemical constituents of P. multiflorum dealt with several anthraquinone, and stilbene derivatives (Nonaka et al, 2005;Ryu et al, 1988;Ryu et al, 2002;Yao et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Farnesyl protein transferase inhibitory components of Polygonum multiflorum

Kwon¹,

Kim

Baek

et al. 2009

Arch. Pharm. Res.

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“…The root of this species has been used in Korea as a traditional folk medicine to treat headache, toothache, aching eyes, abdominal pain, hysteria, bleeding, menstrual disorder and neuralgia (Kimura et al, 1996). During the ongoing search for potent antitumor substances from natural resources (Kim et al, 2003;Kim et al, 2004), it was found that the root extract of the species A. dahurica exhibited significant cytotoxicity against cultured human tumor cell lines in vitro.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Effect of Furanocoumarins from the Root of Angelica dahurica on Cultured Human Tumor Cell Lines

Kim

Ryu

2007

Phytotherapy Research

107

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A bioassay-guided fractionation of the root extract of Angelica dahurica (Umbelliferae) led to the isolation of six furanocoumarins as active ingredients responsible for the antitumoral property. The hexane soluble part of the extract demonstrated a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro, whereas the remaining water soluble part exhibited poor inhibition. Intensive investigation of the hexane soluble part of the extract yielded six furanocoumarins, i.e. isoimperatorin, cnidicin, imperatorin, oxypeucedanin, byakangelicol, oxypeucedanin hydrate, all of which exhibited a significant inhibition on cell proliferation in a dose-dependent manner.

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International Collation of Traditional and Folk Medicine

Cited by 45 publications

References 0 publications

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Farnesyl protein transferase inhibitory components of Polygonum multiflorum

Antiproliferative Effect of Furanocoumarins from the Root of Angelica dahurica on Cultured Human Tumor Cell Lines

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