This purpose of this study was to retrospectively stratify the risks of malignancy according to the mammographic characteristics of Japanese women. We studied the mammographic findings of 1267 Japanese women. We characterized malignant phenotypes according to mass shape, margin and mass density, and by shape and distribution of calcified foci, and to obtain possible predictors for malignancies according to age groups. Lobular and irregular mass shape, no circumscribed margin and higher density turned out to be more powerful predictors for malignancy than other radiological factors (P < 0.001, respectively). The ratio of the cases detected as a mass in those between 21 and 49 years was lower than that of other age groups. In addition, the presence of calcifications and no mammographic abnormalities were the most powerful predictors for malignancies in the young age groups (P < 0.001, respectively). The peak age of breast cancer is between 40 and 49 years in Japan. In the present study, subtle differences were found in the mammographic results for young and old women, in contrast to those of women in the USA and Europe. The results of this study might enable more accurate prediction of biological behavior of the breast lesions in Japanese women. (Cancer Sci 2012; 103: 472-476) T he incidence of breast cancer continues to increase worldwide.(1) Morbidity and death due to breast cancer are lower in Japan than in the USA and Europe, but their rates have been markedly increased in this decade.(2) The effectiveness of screening mammography in reducing death from breast cancer has been established in both the USA, Europe and Japan. (3) Worldwide, millions of mammographic examinations are performed each year, and mammography has become the gold standard for detecting breast disorders. It is important to continue to increase the mammographic screening ratio in order to reduce breast cancer deaths.The American College of Radiology (ACR) has developed the Breast Imaging Reporting and Data System (BI-RADS) to standardize mammographic reporting, to improve communication with clinicians, to reduce confusion regarding mammographic findings, to aid research and to facilitate outcomes monitoring.(4) The use of BI-RADS lexicon is increasing not only in the North American continent but also worldwide. However, some publications have raised the issue of observer variability of interpretation of the lexicon, and have even questioned the expressiveness of the BI-RADS system.(6,7) Some published studies propose classifications of features for the assignment of findings to the various BI-RADS categories. (6,7) Some published reports suggest possible differences in the biological characteristics of breast cancer between women in the USA and Europe and Japanese women.(8) A striking difference is that the peak age for breast cancer is between 40 and 50 years in Japan, whereas the peak age in the USA and Europe is between 60 and 70 years. (8) We have observed that the mammographic findings for Japanese women do not exactly correspond to...