International Hemoglobin Information Center

doi:10.3109/03630267709003425

Hemoglobin

1977

DOI: 10.3109/03630267709003425

|View full text |Cite

International Hemoglobin Information Center

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1980

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The relationship between coding sequences and function in haemoglobin

Eaton

1980

Nature

106

View full text Add to dashboard Cite

Gilbert has suggested that the presence of intervening sequences in DNA, called introns, can speed evolution by allowing novel proteins to be constructed from the pieces of existing ones. This hypothesis further suggests that the coding sequences, called exons, correspond to functional parts of the protein. The most striking example so far is the case of the immunoglobulin gamma heavy chain, where the four polypeptide sequences corresponding to the four coding sequences form structurally and functionally distinct parts of the molecule. The relation between the three coding sequences of the beta globin gene and structure or function is not as obvious, but the central coding sequence does code for the part of the globin chain which forms the haem crevice. To further test the idea that coding sequences correspond to functional units of proteins we consider the relationship between the coding sequences of alpha and beta globin genes and the corresponding parts of the complete, tetrameric haemoglobin molecule.

show abstract

The relationship between coding sequences and function in haemoglobin

Eaton

1980

Nature

106

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

International Hemoglobin Information Center

Cited by 1 publication

References 83 publications

The relationship between coding sequences and function in haemoglobin

The relationship between coding sequences and function in haemoglobin

Contact Info

Product

Resources

About