This study explores the macroeconomic e¤ects of labor unions in a two-country R&D-based growth model in which the market size of each country determines the incentives for innovation. We …nd that an increase in the bargaining power of a wage-oriented union leads to a decrease in employment in the domestic economy. This result has two important implications on innovation. First, it reduces the rates of innovation and economic growth. Second, it causes innovation to be directed to the foreign economy, which in turn causes a negative e¤ect on domestic wages relative to foreign wages in the long run. We also derive welfare implications and calibrate our model to data in the US and the UK to quantify the e¤ects of labor unions on social welfare and wage inequality across countries. Our calibrated model is able to explain about half of the decrease in relative wage between the US and the UK from 1980 to 2007. Furthermore, the decrease in unions'bargaining power leads to quantitatively signi…cant welfare gains in the two countries.JEL classi…cation: O30, O43, E24, J51