International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations

Lawlor, Claire M.; Balakrishnan, Karthik; Bottero, Sergio; Boudewyns, An; Campisi, Paolo; Carter, John; Cheng, Alan; Cocciaglia, Alejandro; deAlarcón, Alessandro; Derkay, Craig S.; Fayoux, P.; Hart, Catherine K.; Hartnick, Christopher J.; Leboulanger, N.; Moreddu, E.; Muntz, Harlan R.; Nicollas, R.; Peer, Shazia; Pransky, Seth M.; Rahbar, Reza; Russell, John; Rutter, Michael J.; Seedat, Riaz Y.; Sidell, Douglas; Smith, Richard J.H.; Soma, Marlene; Strychowsky, Julie E.; Thompson, Dana M.; Triglia, J.-M.; Trozzi, Marilena; Wyatt, Michelle; Zalzal, George H.; Zur, Karen B.; Nuss, Roger C.

doi:10.1016/j.ijporl.2019.109697

Cited by 29 publications

(24 citation statements)

References 25 publications

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“…All patients with chronic hoarseness, stridor, and/or respiratory distress should undergo flexible fibreoptic laryngoscopy or direct laryngoscopy and biopsy. 56 Unfortunately the expertise and facilities to perform these procedures are not easily accessible in developing countries. The papillomas appears as exophytic, pedunculated masses that can be single or multiple (Figure 1).…”

Section: Diagnosismentioning

confidence: 99%

“…32,34 Chest imaging by either chest x-ray or CT scan should be performed in patients with RRP, especially those with a clinical presentation suggestive of pulmonary involvement. 56 Staging The Derkay staging system is the most commonly used system to stage the disease. 57 This system comprises both a functional assessment of clinical features and anatomic assessment of disease distribution.…”

Section: Diagnosismentioning

confidence: 99%

“…Papilloma removal is either with a cupped forceps, laser (CO 2 , KTP, or flash dye), microdebrider or coblation, depending on the surgeon's preference and availability of equipment. 56 In developing countries, the use of cold steel instruments to remove the papillomas is often the only means of treating these patients. 70,71 The aim of surgery is to remove the papillomas with preservation of the normal laryngeal tissue.…”

Section: Disease Coursementioning

confidence: 99%

“…72 Further procedures are usually at set intervals, based on an individual patient's disease severity. 56 Patients in developing countries often need to travel great distances to undergo these procedures, placing a considerable social and economic burden on the family.…”

Section: Disease Coursementioning

confidence: 99%

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<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Seedat

2020

PHMT

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Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of 2 and 6 years. The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. Treatment consists of repeated microlaryngoscopic procedures to remove the papillomas as there is no cure. The poor availability and accessibility of appropriate healthcare services in developing countries are barriers to the early diagnosis and appropriate management of patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP), requiring many patients to have a tracheostomy. The introduction of prophylactic vaccines that include HPV6 and HPV11 is necessary in order to reduce the incidence of JoRRP.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Disease Coursementioning

confidence: 99%

Section: Disease Coursementioning

confidence: 99%

See 2 more Smart Citations

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Seedat

2020

PHMT

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“…Additionally, those types may cause condylomas or recurrent respiratory papillomatosis (RRP) in newborns and juveniles. This recurrent and potentially rapidly progressive and fatal disease [14] may be acquired by the child during labor or through vertical transmission, as DNA HPV was detected in amniotic fluid of individuals with HPV-associated cervical lesions [15]. A variety of papillomaviruses present different strategies for transmission and propagation in the epithelial cells and could also present different types of modulation of host immune system, all of which is an effect of evolutionary adaption [15,16].…”

Section: Papillomaviridae: a Family Older Than Homo Sapiensmentioning

confidence: 99%

Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways

Celewicz

Michalczyk

et al. 2020

Mediators of Inflammation

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As cervical cancer is one of the most common malignancies in women worldwide even with present screening methods, the incidence in most developed countries is not decreasing for the last 15-20 years. A shift has been observed in the age of diagnosis in favour of younger women, and treatment of already developed cervical cancer is a challenge for surgeons. It is imperative to find new diagnostic methods for accurately pointing out patients at high risk of developing malignant disease and developing personalized treatment. Since cervical cancer is almost exclusively associated with HPV infection, understanding changes happening in an infected cell may prove invaluable for search of such methods, but it may also prove helpful in the diagnosis and treatment of other anogenital and nasopharyngeal region cancers. This review follows HPV-related changes in infected cell biology to point what potential markers and targets for therapy are in option when dealing with HPV-related diseases.

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Long‐term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement

Yang

et al. 2021

The Laryngoscope

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Objective To investigate the clinical characteristics and long‐term outcomes of juvenile onset recurrent respiratory papillomatosis (JORRP) with or without pulmonary involvement. Methods A group of patients with JORRP who had clinical course over an extended period of time (at least 5 years) in the Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital were included in this retrospective study. Lung/bronchus involvement was revealed by lung imaging. Data on mortality rate, frequency of surgical interventions, and age of disease onset were collected and analyzed. Results The 192 patients (107 male and 85 female) included had a median [quartiles] age of JORRP onset of 2 [1, 4] years, and median follow‐up duration of 10 [7, 13] years; 17 patients (8.9%) had papilloma with bronchial and pulmonary involvement 7.0 [4.0, 12.5] years after the onset of the disease. Compared to patients without lung involvement, patients with lung involvement had a younger age of disease onset (P = .001), higher frequency of surgical interventions (P < .001), higher mortality rate (OR = 94.909), and an increased risk of tracheotomy that could not be decannulated (P < .001). They also had a younger age of disease onset, and a higher frequency of surgical interventions and mortality compared to patients with tracheotomy but free from lung involvement (P < .001). Conclusions Children with JORRP and with pulmonary involvement have a higher average number of operations per year than those without pulmonary involvement, and pulmonary involvement indicates a higher incidence of tracheotomy that cannot be decannulated. Level of Evidence 4 Laryngoscope, 131:E2277–E2283, 2021

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International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations

Cited by 29 publications

References 25 publications

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways

Long‐term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement

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