International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics

Goossens, Martine; Isa, Fatima; Brinkman, Maree; Mak, David; Reulen, Raoul C.; Wesselius, Anke; Benhamou, Simone; Bosetti, Cristina; Bueno‐de‐Mesquita, Bas; Carta, Angela; Allam, Mohamed Farouk; Golka, Klaus; Grant, Eric J.; Jiang, Xuejuan; Johnson, Kenneth C.; Kellen, Eliane; Vecchia, Carlo La; Lu, Chih Ming; Marshall, James R.; Moysich, Kirsten; Pohlabeln, Hermann; Porru, Stefano; Steineck, Gunnar; Stern, Marianne C.; Tang, Li; Taylor, Jack A.; Brandt, Piet A. van den; Villeneuve, Paul J.; Wakai, Kenji; Weiderpass, Elisabete; Wolk, Alicja; Zhang, Zuo‐Feng; Buntinx, Frank

doi:10.1186/s13690-016-0140-1

Cited by 24 publications

(30 citation statements)

References 33 publications

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“…Details on the methodology of the BLEND consortium have been described elsewhere [44]. Briefly, the primary data from all included studies were incorporated into one dataset.…”

Section: Data Collection and Codingmentioning

confidence: 99%

An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies

et al. 2019

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Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. Methods We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. Results Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HR high 0.85 [95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. Conclusion We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component. Keywords Mediterranean diet • Bladder cancer • Bladder cancer risk • Epidemiology Abbreviations BLEND BLadder cancer Epidemiology and Nutritional Determinants 95% CI 95% confidence interval EPIC European Prospective Investigation into Cancer and Nutrition FFQ Food Frequency Questionnaire HR Hazard ratio MCCS Melbourne Collaborative Cohort Study MIBC Muscle-invasive bladder cancer NMIBC Non-muscle-invasive bladder cancer OR Odds ratio TNM stage Tumour nodes metastasis stage Frits H. M. van Osch has equally contributed to this work as first author.

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“…Details on the methodology of the BLEND consortium have been described elsewhere [44]. Briefly, the primary data from all included studies were incorporated into one dataset.…”

Section: Data Collection and Codingmentioning

confidence: 99%

An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies

et al. 2019

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“…Total participants 56 005 (9) 64 866 (11) 49 457 825 268 445 204 (8) 37 102 (6) 33 856 (6) 40 782 749 328 (8) 75 035 (13) 5632 138 263 6 33 856 825 343 626 782 752 559 (13) 2580 122 465 6 152 4303 9248 7940 (27) 520 15378 (11) 3538 ( approximately three pieces of fruit), using the lowest intake category as a reference. Fruit types (citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products) were each analysed as a continuous variable per 25 g of fruits per day increase and were modelled into quartiles, using the lowest quartile as a reference.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the methodology of the BLEND study have been described elsewhere. 11 Briefly, 13 cohort studies had sufficient data to be eligible for inclusion in our study (ie, method of dietary assessment, geographical region, disease status). About 75% of the study populations originated from centres in Europe including the EPIC studies 12,13 and the Netherlands Cohort Study (NLCS).…”

Section: Study Populationmentioning

confidence: 99%

Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

Jochems

Reulen

Osch

et al. 2020

Intl Journal of Cancer

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While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow‐up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85‐0.99). Although in women the association with fruit consumption was most evident for higher‐risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56‐0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P‐heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94‐1.03), never smokers (HR = 0.96; 95% CI 0.88‐1.05), former smokers (HR = 0.98; 95% CI 0.92‐1.05) or current smokers (HR = 0.95; 95% CI 0.89‐1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women.

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“…The data set used in the present study is part of the 'BLadder cancer Epidemiology and Nutritional Determinant (BLEND)' study, which aims at assessing the association between diet and the BC risk. Details on the methodology of the BLEND consortium have been described elsewhere (10) . The present study included data of eighteen case-control (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) and one nested case-cohort study (29) providing information on diet and BC, from twelve different countries across the world, including data on 8320 BC cases and 23 231 non-cases within the age range of 18-100 years.…”

Section: Study Populationmentioning

confidence: 99%

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

Wesselius

Sinhart

et al. 2020

Br J Nutr

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At present, analysis of diet and bladder cancer (BC) is mostly based on the intake of individual foods. The examination of food combinations provides a scope to deal with the complexity and unpredictability of the diet and aims to overcome the limitations of the study of nutrients and foods in isolation. This article aims to demonstrate the usability of supervised data mining methods to extract the food groups related to BC. In order to derive key food groups associated with BC risk, we applied the data mining technique C5.0 with 10-fold cross-validation in the BLadder cancer Epidemiology and Nutritional Determinants study, including data from eighteen case–control and one nested case–cohort study, compromising 8320 BC cases out of 31 551 participants. Dietary data, on the eleven main food groups of the Eurocode 2 Core classification codebook, and relevant non-diet data (i.e. sex, age and smoking status) were available. Primarily, five key food groups were extracted; in order of importance, beverages (non-milk); grains and grain products; vegetables and vegetable products; fats, oils and their products; meats and meat products were associated with BC risk. Since these food groups are corresponded with previously proposed BC-related dietary factors, data mining seems to be a promising technique in the field of nutritional epidemiology and deserves further examination.

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International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics

Cited by 24 publications

References 33 publications

An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies

An inverse association between the Mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies

Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

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