International studies of the efficacy of etretinate in the treatment of psoriasis

Ehmann, Carl W.; Voorhees, John J.

doi:10.1016/s0190-9622(82)70058-1

Cited by 67 publications

(15 citation statements)

References 14 publications

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“…In the 200 acitretin-treated patients of studies 1-3 and 6-8, the results were consi dered by the investigators to be good or very good for most of the patients, as shown in table III for the different types of psoriasis. Pustular and erythrodermic psoriasis showed a particularly good response to acitretin, as was also the case in the previous etretinate studies [13].…”

Section: Safely Assessmentsupporting

confidence: 84%

Acitretin (Ro 10-1670, Etretin): Overall Evaluation of Clinical Studies

Geiger

Czarnetzki²

1988

Dermatology

104

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Acitretin (Ro 10-1670, etretin) is the free acid derivative of etretinate. This compound possesses a much shorter half-life of elimination than etretinate and was therefore proposed for clinical development. A total of 635 patients with various dermatoses were studied in 12 main clinical trials performed in Europe and in the United States. It was shown that acitretin is effective in the treatment of psoriasis and other diseases of keratinization. Doses between 25 and 35 mg per day are recommended to initiate treatment since marked improvement or clearing was obtained in the majority of patients within this range. Hypervitaminosis A signs and symptoms have been observed in patients treated with acitretin. It is concluded that the efficacy and safety profile of acitretin resembles that of etretinate.

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Section: Safely Assessmentsupporting

confidence: 84%

Acitretin (Ro 10-1670, Etretin): Overall Evaluation of Clinical Studies

Geiger

Czarnetzki²

1988

Dermatology

104

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“…This remarkable drug (isotretinoin) and certain aromatic retinoids (etretinate) have revolutionized the dermato logic treatment of devastating chronic disor ders of deranged keratinization [8,9].…”

Section: Historical Perspectivesmentioning

confidence: 99%

Treatment of Photoaged Skin with Topical Tretinoin

Kligman

Leyden²

1993

Skin Pharmacol Physiol

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Once-daily application of tretinoin to photodamaged facial skin for 0-12 months results in substantial clinical and histologic improvement. As regards appearance, fine wrinkles become effaced, dyspigmentations fade, surface becomes smooth and develops a ‘rosy glow’. Histologically, atrophy and dysplasia of the epidermis are completely corrected. New collagen is laid down subepidermally along with the development of new small vessels (angiogenesis). Mesenchymal dermal cells become more numerous and larger. The sum of changes is toward more youthful skin.

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“…In placebocontrolled trials, etretinate showed good to excellent results in the majority of patients [15].…”

Section: Use O F Etretinatementioning

confidence: 99%

“…Although psoriasis vulgaris does not respond as effectively to etretinate as the previous two forms, there is extensive litera ture documenting its efficacy even when used as a monotherapy [10,15]. In placebocontrolled trials, etretinate showed good to excellent results in the majority of patients [15].…”

Section: Use O F Etretinatementioning

confidence: 99%