The internationalization of logistics activities has become inevitable for many transport and logistics companies that intend to expand their business beyond the borders of the national economy. Thanks to this process, i.e., greater dispersion of the value chain and flow of globally exchanged goods and information, there are changes in the characteristics of logistics systems at the global level. The aim of this paper is to point out, based on a comprehensive analysis of the internationalization process, its close connection with cross-border activities of transport-logistics companies. The paper analyzes the road transport activities, on the example of Turkey, due to their highest visibility within the overall logistics activities of the company. Thanks to the favorable geostrategic position of Turkey and the development of the road network, road transport has become the most widespread mode of transport whose role in the logistics sector and the realization of cross-border activities of logistics companies is growing from year to year.