International Trends in the Incidence of Testicular Cancer: Lessons from 35 Years and 41 Countries

Gurney, Jason; Florio, Andrea A.; Znaor, Ariana; Ferlay, Jacques; Laversanne, Mathieu; Sarfati, Diana; Bray, Freddie; McGlynn, Katherine A.

doi:10.1016/j.eururo.2019.07.002

Cited by 138 publications

(114 citation statements)

References 20 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Testicular cancer afflicts mostly adolescents and young men. 99 While it was previously thought that most of the risk for its development is determined already in utero, it is now evident that postnatal factors also play an important role, perhaps by influencing progression of existing in situ testicular carcinomas. 100 Across the world, increased risk of testicular cancer, which is predominantly of germ cell type classified into seminoma and non-seminoma, had often been reported with high SES but the gap has started to narrow in recent decades.…”

Section: Male Genital and Prostate Cancersmentioning

confidence: 99%

Socioeconomic inequalities in cancer incidence in Europe: a comprehensive review of population-based epidemiological studies

Mihor

Tomšič

Žagar

et al. 2020

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundSince the end of the previous century, there has not been a comprehensive review of European studies on socioeconomic inequality in cancer incidence. In view of recent advances in data source linkage and analytical methods, we aimed to update the knowledge base on associations between location-specific cancer incidence and individual or area-level measures of socio-economic status (SES) among European adults.Materials and methodsWe systematically searched three databases (PubMed, Scopus and Web of Science) for articles on cancer incidence and SES. Qualitative synthesis was performed on the 91 included English language studies, published between 2000 and 2019 in Europe, which focused on adults, relied on cancer registry data and reported on relative risk (RR) estimates.ResultsAdults with low SES have increased risk of head and neck, oesophagogastric, liver and gallbladder, pancreatic, lung, kidney, bladder, penile and cervical cancers (highest RRs for lung, head and neck, stomach and cervix). Conversely, high SES is linked with increased risk of thyroid, breast, prostate and skin cancers. Central nervous system and haematological cancers are not associated with SES. The positive gap in testicular cancer has narrowed, while colorectal cancer shows a varying pattern in different countries. Negative associations are generally stronger for men compared to women.ConclusionsIn Europe, cancers in almost all common locations are associated with SES and the inequalities can be explained to a varying degree by known life-style related factors, most notably smoking. Independent effects of many individual and area SES measures which capture different aspects of SES can also be observed.

show abstract

Section: Male Genital and Prostate Cancersmentioning

confidence: 99%

Socioeconomic inequalities in cancer incidence in Europe: a comprehensive review of population-based epidemiological studies

Mihor

Tomšič

Žagar

et al. 2020

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

“…Testicular cancer is a rare disease, but nevertheless the most common type of malignancy encountered in young men, with a peak incidence between the age of 15 and 44 [1]. Testicular germ cell tumors (TGCTs) are the most frequent type of testicular cancer, accounting for approximately 95% of all testicular cancers [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up―A Copenhagen Experience

Mørup

Meyts

Juul

et al. 2020

Cancers

View full text Add to dashboard Cite

New microRNA-based serum biomarkers (miRNA-367-3p, -371a-3p, -372-3p, and -373-3p) have shown great potential for the detection of testicular germ cell tumors (TGCTs), but few studies have investigated the clinical utility and performance of these tests in treatment monitoring. In this study, circulating miRNA levels were measured, together with serum tumor markers alpha-fetoprotein (AFP), β-subunit of human chorionic gonadotropin (β-HCG) and lactate dehydrogenase (LDH) in 406 consecutive blood samples obtained during the treatment and follow-up of 52 TGCT patients at the Copenhagen University Hospital. After testing three different methods of RNA isolation from peripheral blood and PCR quantification in a subset of samples (n = 15), the best performing setup of targeted isolation of miRNAs inside and outside exosomes was selected to analyze all samples. At primary diagnosis, the miRNAs significantly outperformed the serum tumor markers, with a sensitivity and specificity of 78% and 100% (based on 40 patients), respectively. The picture was not as clear when patient trajectories were investigated, with both positive and negative signals for miRNAs and serum tumor markers. To establish whether measuring miRNAs adds value beyond the primary diagnosis, large prospective clinical trials comparing miRNAs and classical tumor markers during the treatment and follow-up of TGCT patients are needed.

show abstract

“…Testicular germ cell tumors (TGCTs) represent one of the most common solid tumors in young men [ 1 ]. TGCTs of young adult type originate from a precursor cell, germ cell neoplasia in situ (GCNIS), that retains fetal germ cell characteristics, but undergoes malignant transformation after puberty and forms either an invasive seminoma or a non-seminoma [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

Lorenzen

Nielsen

Andreassen

et al. 2020

Cancers

View full text Add to dashboard Cite

Luteinizing hormone/choriogonadotropin receptor (LHCGR) regulates gonadal testosterone production and recent studies have suggested a growth-regulatory role in somatic cancers. Here, we established that LHCGR is expressed in a fraction of seminoma cells and germ cell neoplasia in situ (GCNIS), and the seminoma-derived cell line TCam2 released LHCGR into the medium. LH treatment induced proliferation of TCam2 cells in vitro, while hCG treatment induced a non-significant 51% increase in volume of tumors formed in a TCam2 xenograft model. A specific ELISA was used to detect a soluble LHCGR in serum. Serum concentrations of soluble LHCGR could not distinguish 4 patients with GCNIS and 216 patients with testicular germ cell tumors (TGCTs) from 297 infertile or 148 healthy young men. Instead, serum LHCGR levels were significantly higher in 112 patients with a seminoma >5 cm or elevated serum lactate dehydrogenase (LDH) compared with men harboring smaller seminomas <2 cm or normal LDH levels. Serum LHCGR levels in TGCT patients could not predict relapse irrespective whether determined pre- or post-orchiectomy. Combined, these novel findings suggest that LHCGR may be directly involved in the progression and growth of seminomas, and our retrospective pilot study suggests that serum LHCGR may have some prognostic value in men with seminoma.

show abstract

International Trends in the Incidence of Testicular Cancer: Lessons from 35 Years and 41 Countries

Cited by 138 publications

References 20 publications

Socioeconomic inequalities in cancer incidence in Europe: a comprehensive review of population-based epidemiological studies

Socioeconomic inequalities in cancer incidence in Europe: a comprehensive review of population-based epidemiological studies

Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up―A Copenhagen Experience

Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

Contact Info

Product

Resources

About