Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for hydrogel tissue engineering scaffolds

Daniele, Michael A.; Adams, André A.; Naciri, Jawad; North, Stella H.; Ligler, Frances S.

doi:10.1016/j.biomaterials.2013.11.009

Cited by 221 publications

(228 citation statements)

References 57 publications

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“…However, despite the chemical cross-linking, the material's mechanical properties are negatively affected when applied at body temperature due to the melting of the collagen like triple helices. To address this issue, Gel-MOD has already been blended with other polymers, both synthetic as well as natural to improve their mechanical performance [15]. One commonly applied strategy aims at the formation of (semi-)interpenetrating networks (IPNs) by cross-linking the gelatin independently from the other polymer [16,17].…”

Section: Materials Synthesismentioning

confidence: 99%

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Graulus

Mignon

Vlierberghe

et al. 2015

European Polymer Journal

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a b s t r a c tWhen it comes to failing or injured tissues and organs, patients often end up on waiting lists for tissue or even organ transplantation negatively affecting the patient's quality of life. The multidisciplinary research field of tissue engineering may offer more innovative ways to replace or ideally regenerate failing tissues and organs. A widely used material in this research field is gelatin because of its biocompatibility and interesting hydrogel forming properties. However, at body temperature gelatin's mechanical properties are greatly reduced due to the dissolution of collagen-like triple helices. With the aim to obtain materials that retain their mechanical properties at body temperature, we propose to combine sodium alginate and methacrylamide-modified gelatin (Gel-MOD) in the form of a graft copolymer to obtain a material that closely resembles the extracellular matrix. The obtained materials can be cross-linked via three distinct pathways including cation mediated, temperature mediated or via covalent bond formation after UV irradiation in the presence of a photo-initiator. The current contribution covers the synthesis of the above mentioned alginate-graft-gelatin copolymers and the characterization of the resulting hydrogels. The materials developed are highly hydrophilic, showing high gel fractions and satisfactory mechanical properties. Moreover the attained storage moduli were tunable by divalent cation addition (72-275% increase at 21°C, 42-405% increase at 40°C). One formulation was found to outperform Gel-MOD in terms of mechanical properties at 40°C, thus indicating the proposed strategy can be used to improve the mechanical properties of gelatin-based hydrogels. Moreover, in vitro biocompatibility assays indicated that cell adhesion and proliferation improves with increasing gelatin content. The present paper illustrates that the developed triple cross-linkable materials are suitable cell carriers, promising to be applied for biomedical purposes.

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Section: Materials Synthesismentioning

confidence: 99%

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Graulus

Mignon

Vlierberghe

et al. 2015

European Polymer Journal

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“…Hydrogels have received a considerable attention for use in tissue engineering scaffolds (with gelatin methacrylamide/PEG [72], silk fibroin/poly(vinyl alcohol) [73], silk fibroin/gelatin [74] or others [75]), cartilage tissue engineering (with poly (ethylene glycol)/agarose [76]), vascular tissue engineering (dextran/gelatin [77]). Mechanically enhanced properties (e.g., Young's moduli) rivaling those of natural load-bearing tissues was found in a poly (acrylic acid)/end-linked poly (ethylene glycol) crosslinked material [78].…”

Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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Abstract:In this paper, we propose to review the ways to produce, through photopolymerization, interpenetrating polymer networks (IPN) based, e.g., on acrylate/epoxide or acrylate/vinylether blends and to outline the recent developments that allows a one-step procedure (concomitant radical/cationic polymerization), under air or in laminate, under various irradiation conditions (UV/visible/near IR; high/low intensity sources; monochromatic/polychromatic sources; household lamps/laser diodes/Light Emitting Diodes (LEDs)). The paper illustrates the encountered mechanisms and the polymerization profiles. A short survey on the available monomer systems and some brief examples of the attained final properties of the IPNs is also provided.

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“…Numerous natural [2] and synthetic hydrogels [3], or a combination of both [4], have been developed. Natural hydrogels usually possess excellent biocompatibility and low toxicity, but with poor strength and toughness [5].…”

Section: Introductionmentioning

confidence: 99%

Natural polysaccharides promote chondrocyte adhesion and proliferation on magnetic nanoparticle/PVA composite hydrogels

Hou

Nie

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Interpenetrating networks based on gelatin methacrylamide and PEG formed using concurrent thiol click chemistries for hydrogel tissue engineering scaffolds

Cited by 221 publications

References 57 publications

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Cross-linkable alginate-graft-gelatin copolymers for tissue engineering applications

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Natural polysaccharides promote chondrocyte adhesion and proliferation on magnetic nanoparticle/PVA composite hydrogels

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