Interpenetrating polymer network hydrogels based on poly(ethylene glycol) macromer and chitosan

Lee, Seung Jun; Kim, Seong Soo; Lee, Young Moo

doi:10.1016/s0144-8617(99)00088-0

Cited by 184 publications

(39 citation statements)

References 24 publications

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“…It has been reported that carrageenan binds more water than HPMC in the same ratio, due to high mobility of the water molecules between polymer chains wherein sulphate groups get hydrated (22). Both carrageenan and chitosan owe their solubility in water based solvents to their charged groups, since except for these groups, the polymer backbones are quite hydrophobic (23). The rate of carrageenan erosion was affected by the pH of the dissolution medium.…”

Section: Swelling and Matrix Erosion Studiesmentioning

confidence: 99%

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

et al. 2007

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Abstract. The purpose of this research was to explore theapplication of ionic interactions between naproxen sodium (NS) and chitosan (CH) in complexes (NSC) prepared by tray drying (TD) and spray drying (SD) methods. Drug-polymer ratio (1:1) in the NSC was optimized on the basis of dialysis studies. The particulate systems of NSC were prepared by tray drying (TD) and spray drying (SD) methods. Release retarding polymers were added to the NSC and to the physical mixtures containing NS-CH and their effects on water uptake, matrix erosion and drug release at different pH were compared. Spray dried complexes (SDC) were spherical, free flowing, light and fine amorphous particles in contrast to the crystalline, hard, tenacious, irregularly shaped, denser tray dried complexes (TDC) with poor flowability. Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR) patterns confirm the conversion of crystalline to high energy amorphous phase suitable for ionic interactions in NSC. Presence of release retarding polymers, kappa carrageenan and hydroxypropylmethylcellulose (HPMC) in the NSC compacts retarded the drug release and improved the matrix integrity. Carrageenan matrices exhibited more retardation than HPMC tablets. FTIR patterns, erosion, swelling and drug release from matrices support ionic interactions between NS and CH in NSC. The reasons for retarded drug release from the chitosan matrices at acidic pH include poor solubility of drug at acidic pH, formation of a rate limiting polymer gel barrier along the periphery of matrices and the ionic interactions between oppositely charged moieties.

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Section: Swelling and Matrix Erosion Studiesmentioning

confidence: 99%

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

et al. 2007

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“…The water absorbed by AA/AAm/DMAm hydrogels is quantitatively represented by the equilibrium water content (EWC) [35,36], where…”

Section: Swelling Measurementsmentioning

confidence: 99%

Synthesis, Characterization, Swelling Studies and Dye Removal of Chemically Crosslinked Acrylic Acid/Acrylamide/N,N-Dimethyl Acrylamide Hydrogels

Ibrahim¹

2016

AJAC

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Polymeric hydrogels of acrylic acid (AA), acrylamide (AAm) and N,N-Dimethylacrylamide (DMAm) were prepared by free-radical polymerization at 70°C in methanol, using allylpentaerythritol (APE) as a multifunctional crosslinker and benzoyl peroxide (BPO) as an initiator. The effects of DMAm concentration and variation of pH solutions on the swelling behavior of polymers were investigated. Also AA/AAm/DMAm hydrogel was used in experiments on adsorption of a water soluble monovalent cationic dye such as Basic Blue 9 (BB-9; Methylene blue). FT-IR results confirmed the Structural features of the obtained hydrogels. Results from SEM observation showed a three dimensional porous structure of the hydrogels. Thermogravimetric analysis (TGA) of hydrogels was performed to investigate the thermal properties. The swelling results showed an increase of the swelling of AA/AAm/DMAm hydrogels as the content of DMAm increases in the hydrogel. The swelling percentage and swelling kinetics parameters such as initial swelling rate and swelling rate constant were determined. It was also shown that the swelling of hydrogels increased with the increase of pH and the maximum extent was reached at pH 8 in all compositions. The uptake of BB-9 to AA/AAm/DMAm hydrogel is studied by batch adsorption technique at 25°C. The hydrogel in the dye solution showed coloration. Kinetics and isotherms of dye adsorption were also studied. It was found that the adsorption kinetics of hydrogels followed a pseudo-second-order model. Equilibrium isotherms were analyzed using the Langmuir and Freundlich isotherms. It was seen that the Freundlich model fits the adsorption data better than the Langmuir model.

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“…IPN hydrogel with thermo sensitive properties and good swelling property has been widely used in drug delivery. Lee et al [8] obtained the IPN hydrogels from the PEG monomer, chitosan and glutaraldehyde as crosslinking agent under ultraviolet light. The equilibrium water content (EWC) is in the range of 74 -97%.…”

Section: Internal Passing Network Hydrogelmentioning

confidence: 99%

Recent progress on the research of high strength hydrogels

Zhang¹,

Liang²,

Wang³

et al. 2015

Proceedings of the 5th International Conference on Advanced Design and Manufacturing Engineering

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Keywords: hydrogel, high strength, mechanical property. Abstract. The hydrogel is a three-dimensional reticular polymer with high water content, which was used in various fields such as medicine, biology and environmental protection. However, the characteristic of lower mechanical properties limited its application. Therefore, the improvement of the mechanical strength of hydrogel has become the focus of researchers. This paper mainly introduced the progress of research on synthesis of several kinds of high strength hydrogel, including slip ring hydrogel, Tetra-PEG hydrogel, internal passing network hydrogel, double network hydrogel and nanocomposite hydrogel. The analysis of the influence factors on mechanical properties was discussed.

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Interpenetrating polymer network hydrogels based on poly(ethylene glycol) macromer and chitosan

Cited by 184 publications

References 24 publications

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Effect of Drying Methods on Swelling, Erosion and Drug Release from Chitosan–Naproxen Sodium Complexes

Synthesis, Characterization, Swelling Studies and Dye Removal of Chemically Crosslinked Acrylic Acid/Acrylamide/N,N-Dimethyl Acrylamide Hydrogels

Recent progress on the research of high strength hydrogels

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