Recent progress on the research of high strength hydrogels

Zhang, Da; Liang, Chen; Wang, Zaiqin; Wei, Tao

doi:10.2991/icadme-15.2015.372

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Many thermoplastic polymers with optimal mechanical properties for the application of cartilage regeneration, that are already approved for clinical use, have a high melting temperature that decreases the cell viability in a normal FDM bioprinting process. Low temperature biomaterials [19][20][21] and printing procedures 22 have been reported in the literature, but these constructs present a lower mechanical and biodegradability behavior. The optimal mechanical stiffness and biodegradation time of the construct depend on the rehabilitation procedure, and higher joint loading after surgery will demand higher stiffness of the constructs and a higher biodegradation time.…”

Section: Discussionmentioning

confidence: 99%

Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration

Baena

Jiménez

López‐Ruiz

et al. 2019

Exp Biol Med (Maywood)

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Biofabrication technologies with layer-by-layer simultaneous deposition of a polymeric matrix and cell-laden bioinks (also known as bioprinting) offer an alternative to conventional treatments to regenerate cartilage tissue. Thermoplastic polymers, like poly-lactic acid, are easy to print using fused deposition modeling, and the shape, mesh structure, biodegradation time, and stiffness can be easily controlled. Besides some of them being clinically approved, the high manufacturing temperatures used in bioprinting applications with these clinically available thermoplastics decrease cell viability. Geometric restriction prevents cell contact with the heated printed fibers, increasing cell viability but comprising the mechanical performance and biodegradation time of the printed parts. The objective of this study was to develop a novel volume-by-volume 3D-biofabrication process that divides the printed part into different volumes and injects the cells after each volume has been printed, once the temperature of the printed thermoplastic fibers has decreased. In order to show the suitability of this process, chondrocytes were isolated from osteoarthritic patient samples and after characterization were used to test the feasibility of the process. Human chondrocytes were bioprinted together with poly-lactic acid and apoptosis, proliferation and metabolic activity were analyzed. This novel volume-by-volume 3D-biofabrication procedure prints a mesh structure layer-by-layer with a high adhesion surface/volume ratio, driving a rapid decrease in the temperature, avoiding contact with cells in high temperature zones. In our study, chondrocytes survived the manufacturing process, with 90% of viability, 2 h after printing, and, after seven days in culture, chondrocytes proliferated and totally colonized the scaffold. The use of the volume-by-volume-based biofabrication process presented in this study shows valuable potential in the short-term development of bioprint-based clinical therapies for cartilage injuries. Impact statement 3D bioprinting represents a novel advance in the area of regenerative biomedicine and tissue engineering for the treatment of different pathologies, among which are those related to cartilage. Currently, the use of different thermoplastic polymers, such as PLA or PCL, for bioprinting processes presents an important limitation: the high temperatures that are required for extrusion affect the cell viability and the final characteristics of the construct. In this work, we present a novel bioprinting process called volume-by-volume (VbV) that allows us to preserve cell viability after bioprinting. This procedure allows cell injection at a safe thermoplastic temperature, and also allows the cells to be deposited in the desired areas of the construct, without the limitations caused by high temperatures. The VbV process could make it easier to bring 3D bioprinting into the clinic, allowing the generation of tissue constructs with polymers that are currently approved for clinical use.

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Section: Discussionmentioning

confidence: 99%

Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration

Baena

Jiménez

López‐Ruiz

et al. 2019

Exp Biol Med (Maywood)

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“…During gelling process, the transition between sol and gel states can occur also as response to environmental stimuli as pH and temperature variations; related structures are usually referred as stimuli‐responsive hydrogels 61 . Unfortunately, these hydrogels are often characterized by poor mechanical properties (due to the low density and the small friction force of the polymer chains or the formation of non‐homogenous hydrogel networks 62 ) and to overcome this limitation an interesting strategy involves the insertion of metals able to change their oxidation state and to create redox‐triggered hydrogels 63 . Cu + /Cu 2+ , Fe 2+ /Fe 3+ , and Co 2+ /Co 3+ redox couples can be employed and their coordination geometry and preferential ligands depend on redox states, which enable electrochemical assembly of synthetic polymers or natural biomolecules into hydrogels 64 .…”

Section: From Hydrogels To Metallogelsmentioning

confidence: 99%

Modulation of hydrogel networks by metal ions

Manna

Florio

Natale

et al. 2023

Journal of Peptide Science

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Self‐assembling hydrogels are receiving great attention for both biomedical and technological applications. Self‐assembly of protein/peptides as well as organic molecules is commonly induced in response to external triggers such as changes of temperature, concentration, or pH. An interesting strategy to modulate the morphology and mechanical properties of the gels implies the use of metal ions, where coordination bonds regulate the dynamic cross‐linking in the construction of hydrogels, and coordination geometries, catalytic, and redox properties of metal ions play crucial roles. This review aims to discuss recent insights into the supramolecular assembly of hydrogels involving metal ions, with a focus on self‐assembling peptides, as well as applications of metallogels in biomedical fields including tissue engineering, sensing, wound healing, and drug delivery.

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“…The hydrogels found applications in various fields including biomaterials, biotechnology, and pharmacy [ 121 ]. However, it should be stressed that they exhibit poor stability and mechanical properties [ 122 ]. In order to solve these problems, nanocomposites hydrogels can be used.…”

Section: Application Of Poss Derivatives In Cosmetic Productsmentioning

confidence: 99%

Silsesquioxanes in the Cosmetics Industry—Applications and Perspectives

et al. 2022

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The rising demand for innovative and sophisticated personal care products is a driving factor for manufacturers to obtain new formulations that will fulfill the customers’ preferences. In recent years, silsesquioxanes have attracted the attention of the cosmetics industry. These compounds have been proposed to be used in novel cosmetic formulations as emollient, dispersant, and viscosity modifiers. Therefore, this publication aims to review the main important aspects of polyhedral oligosilsesquioxanes as ingredients of personal care formulations, taking into consideration different types of products. The methods of obtaining these compounds were also presented. Additionally, the detailed analysis of patents dedicated to the application of silsesquioxanes in cosmetic formulations was also performed.

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Recent progress on the research of high strength hydrogels

Cited by 6 publications

References 12 publications

Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration

Volume-by-volume bioprinting of chondrocytes-alginate bioinks in high temperature thermoplastic scaffolds for cartilage regeneration

Modulation of hydrogel networks by metal ions

Silsesquioxanes in the Cosmetics Industry—Applications and Perspectives

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