Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery

Comparative bio-safety and in vivo evaluation of native or modified locust bean gum-PVA IPN microspheres

“…3. The FTIR spectral detail of BH is reported earlier [12,13]. From FTIR study of the optimized formulations after 180 days of stability study, no major changes were detected in the functional group frequencies of the optimized formulations.…”

“…The usual melting endotherm of BH is 196 • C [12]. The detail of DSC study of stability samples are presented in Fig.…”

“…LBG-PVA IPN and CMLBG-PVA IPN microspheres were prepared and characterized. The details were reported in our recent publications [12,13]. All three IPNs were optimized in terms of their drug entrapment efficiency (DEE, %), particle size (m) and cumulative percent release (CPR, %) by taking gum: polymer, amount of glutaraldehyde and drug loading as independent variables.…”

“…In a recent study, we have evaluated the process optimization, development and detailed characterization of LBG-PVA IPN microspheres for controlled delivery of BH [12]. It required high amount of crosslinker (glutaraldehyde) for crosslinking and the microspheres were having poor drug entrapment efficiency.…”

New copolymers with triazole pendant groups: Synthesis, characterization and their application to remove heavy metals

“…Moreover, attempt was made to prepare an interpenetrated network hydrogel microsphere by using PVA and locust bean gum for oral controlled drug delivery [2]. Such modification may provide PVA with pendant functional groups or graft polymer chains, and thus expand their applications in different fields.…”