Interplay between matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in acute asthma exacerbation and airway remodeling

Mohamed, Ghada Mahmoud; Farres, Mohamed Nazmy; Mahmoud, Hala

doi:10.1016/j.ejcdt.2012.10.020

Cited by 9 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of the current study revealed that the serum levels of MMP-9, TIMP-1, and MMP-9 /TIMP-1 ratio were significantly higher in patients with uncontrolled asthma than in patients with controlled asthma. It was reported that serum MMP-9 level was increased in asthma exacerbation and after allergenic challenge and decreased by corticosteroids [4,5]. The circulating and sputum MMP-9 concentrations were increased in patients with asthma exacerbations compared with patients with stable asthma.…”

Section: Discussionmentioning

confidence: 95%

“…Many authors reported that serum levels of MMP-9 were increased in asthma compared with those seen in healthy control subjects [5,10,11]. Others reported that serum MMP-9 levels of asthmatic children were significantly higher than those of healthy controls [2,12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it was found that MMP-9 and TIMP-1 concentrations as well as MMP-9/TIMP-1 ratio, were increased in the sputum of asthma and chronic bronchitis patients, and are thought to be related to airflow obstruction [5,14,15]. Karakoc and coworkers reported that children with asthma showed significantly higher MMP-9 levels of EBC (Exhaled breath condensate) in comparison with the controls [16].…”

Section: Discussionmentioning

confidence: 99%

“…MMP-9 is the predominant MMP in asthma, and its expression is enhanced when patients have spontaneous exacerbations or in response to local instillation of allergen in the airway. As acute inflammation resolves, MMP-9 levels return toward normal [4,5].…”

Section: Introductionmentioning

confidence: 98%

“…Thus, an increase in the molar ratio of MMP/TIMP may favour tissue injury, while the reverse could be associated with increased fibrosis [3,4]. It is possible that the increased levels of TIMP-1 observed in asthmatics may represent an endogenous protective mechanism to down-regulate the proteolytic activity of MMPs in lung parenchyma or that an excess of TIMP-1 could lead to airway fibrosis [5]. MMP-9 is the predominant MMP in asthma, and its expression is enhanced when patients have spontaneous exacerbations or in response to local instillation of allergen in the airway.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma

Hassan¹,

Mohamed-Hussein²,

Mohammed³

et al. 2015

J Pulm Respir Med

View full text Add to dashboard Cite

Rationale: Airway remodelling is clinically defined as persistent airflow obstruction despite aggressive antiinflammatory therapies. Assessment of airway remodelling by analysis of serum markers has been developed as minimally invasive procedures. Aim of the work: Evaluate the usefulness of estimation of serum MMP-9, TIMP-1 and their ratio, as non-invasive markers of airway remodelling in asthmatics. Patients and methods: The study included 68 asthmatics and 20 controls. Patients were classified according to levels of asthma control, severity and disease duration. Serum samples were taken to estimate levels of MMP-9, TIMP-1 and their ratio. Results: Serum MMP-9, TIMP-1, and MMP-9/TIMP-1 were significantly higher in asthmatics than controls, in uncontrolled vs. controlled asthma (P<0.001). Also they were significantly higher in severe and moderate asthma than in mild asthma (P<0.000), and in patients with disease duration >5 years vs. <5 years (P˂0.001). There was significant positive correlation between studied parameters (p<0.000) and significant negative correlation between the biomarkers and FEV 1 (p<0.001). Conclusion: Serum MMP-9, TIMP-1, and MMP-9/TIMP-1 could be considered as non-invasive markers of airway remodelling that can bypass biopsy sampling. Serum sample is easily handled and not subjected to technical error as sputum or BAL fluid.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma

Hassan¹,

Mohamed-Hussein²,

Mohammed³

et al. 2015

J Pulm Respir Med

View full text Add to dashboard Cite

show abstract

Fibroblast-to-myofibroblast transition in bronchial asthma

Michalik

Wójcik-Pszczoła

Paw

et al. 2018

Cell. Mol. Life Sci.

122

118

View full text Add to dashboard Cite

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. Phenotypic fibroblast-to-myofibroblast transition represents one of the primary mechanisms by which myofibroblasts arise in fibrotic lung tissue. Fibroblast-to-myofibroblast transition requires a combination of several types of factors, the most important of which are divided into humoural and mechanical factors, as well as certain extracellular matrix proteins. Despite intensive research on the nature of this process, its underlying mechanisms during bronchial airway wall remodelling in asthma are not yet fully clarified. This review focuses on what is known about the nature of fibroblast-to-myofibroblast transition in asthma. We aim to consider possible mechanisms and conditions that may play an important role in fibroblast-to-myofibroblast transition but have not yet been discussed in this context. Recent studies have shown that some inherent and previously undescribed features of fibroblasts can also play a significant role in fibroblast-to-myofibroblast transition. Differences observed between asthmatic and non-asthmatic bronchial fibroblasts (e.g., response to transforming growth factor β, cell shape, elasticity, and protein expression profile) may have a crucial influence on this phenomenon. An accurate understanding and recognition of all factors affecting fibroblast-to-myofibroblast transition might provide an opportunity to discover efficient methods of counteracting this phenomenon.

show abstract

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model

Kumari

Singh²,

Dash

et al. 2018

Inflammopharmacol

View full text Add to dashboard Cite

Interplay between matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in acute asthma exacerbation and airway remodeling

Cited by 9 publications

References 27 publications

Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma

Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) as Non-Invasive Biomarkers of Remodelling in Asthma

Fibroblast-to-myofibroblast transition in bronchial asthma

Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model

Contact Info

Product

Resources

About