Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model

Nanocurcumin: A Promising Candidate for Therapeutic Applications

“…Curcumin control the inflammatory response through decreasing the activity of cyclooxygenase-2 (COX-2), lipoxygenase (LOX), phospholipases A2 (PLA2s) and inducible nitric oxide synthase (iNOS) enzymes pathway that obstructs the prostaglandin synthesis and pro-inflammatory leukotrienes and essential inflammatory response mediators Shakeri and Boskabady, 2017;Yuan et al, 2018;Farhood et al, 2019;Kumari et al, 2019;Lee et al, 2020 2 Anticancer STAT3 and NF-kB signaling pathways play major role in cancer growth, curcumin effectively obstruct the activity of STAT3 and NF-kB. Besides, curcumin obstructs cancer formation, migration, and invasion by control the expression of Sp-1 and its housekeeping genes.…”

Curcumin (a constituent of turmeric): New treatment option against COVID‐19

“…On the other hand, there are many studies due to the inhibitory effects of curcumin on 5-LOX and COX-2 (Rao, 2007). Furthermore, curcumin has shown these inhibitory effects in the airway studies (Kumari, Singh, Dash, & Singh, 2019;Yuan, Liu, Ma, Zhang, & Xie, 2018). Thus, curcumin is likely to inhibit the activity of bradykinin by inhibiting the COX enzyme (Figure 3).…”

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma

“…Furthermore, NTHi has a higher affinity for the damaged mucosa [41], leading to long-term colonization and chronic airway inflammation. There is a cycle of NTHi infection and oxidative stress: ROS induce the production of cytokines and chemokines by inducing oxidative stress-sensitive NF-κB transcription in bronchial epithelial cells, leading to further inflammation and more oxidative stress [42,43]; this process further damages the airway mucosa and promotes the sustained colonization of NTHi. At the same time, sustained colonization promotes the progression of airway inflammation and the increase in oxidative stress.…”