Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

Rybka, Joanna; Kędziora–Kornatowska, Kornelia; Banaś-Leżańska, Patrycja; Majsterek, Ireneusz; Carvalho, Lívia A.; Cattaneo, Annamaria; Anacker, Christoph; Kędziora, J

doi:10.1016/j.freeradbiomed.2013.05.019

Cited by 123 publications

(100 citation statements)

References 68 publications

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“…It has been reported that elevated MDA was related with different depressive disorder, like auditory-verbal working memory, impairment of visualspatial, and, short-term and delayed declarative memory [6,20,21]. In several studies, MDA levels have been found to be increased in depression [17,22]. In our study also we found significantly increased levels of MDA in patients of major depressive disorder with a p value < 0.0001 which suggests an extremely significant relationship.…”

Section: Discussionsupporting

confidence: 72%

“…SOD activity found to be decreased in different depressive animal model [38,39]. Rybka et al, reported low levels of SOD in the cases of major depression as compared to healthy controls but this was not significant [22]. However, in another study the level of SOD has been found to be significantly decreased as compared to healthy controls [40].…”

Section: Discussionmentioning

confidence: 93%

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Oxidative Stress and Major Depression

Bajpai

Verma

Srivastava

et al. 2014

JCDR

136

124

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 93%

Oxidative Stress and Major Depression

Bajpai

Verma

Srivastava

et al. 2014

JCDR

136

124

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“…Neopterin -levels of plasma neopterin are increased in depressed patients (Celik et al, 2010, Maes et al, 2013, Maes et al, 1994, Maes et al, 2012b, Rybka et al, 2013 and particularly in patients suffering from melancholic symptoms (Maes et al, 2012a, Maes et al, 1994. Greater concentrations of neopterin were also reported in patients suffering from two or more episodes of depression compared to first-episode populations (Celik et al, 2010).…”

Section: Accepted M Manuscriptmentioning

confidence: 97%

“…Elevated levels of MDA have also been identified in patients diagnosed with recurrent depressive disorder (Rybka et al, 2013), and concentrations are even greater in depressed patients with a history of recurrent episodes of depression compared to patients suffering from their first episode (Stefanescu and Ciobica, 2012).…”

Section: Oxidative Stress and Antioxidant Defence Biomarkersmentioning

confidence: 99%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

312

180

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Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.

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“…Psychological distress may increase the risk of occult bleeding in the digestive tract (Peura 1987), and activated sympathetic tone may inhibit erythropoiesis (Maestroni 2000;Umegaki et al 2011;Stewart and Hirani 2012). Also there is possibility that iron metabolism and erythron affect the prooxidant and antioxidant systems and proinflam matory cytokine levels, and induce depression (Rybka et al 2013). …”

Section: Strengthsmentioning

confidence: 99%

Association between Mean Corpuscular Hemoglobin Concentration and Future Depressive Symptoms in Women

Lee

Nadimpalli²,

Yoon

et al. 2017

Tohoku J. Exp. Med.

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Insufficient hemoglobin and depression share several symptoms and often occur in the same patients. Here, we sought to clarify their relationship by investigating two indices of oxygenation at the tissue level: mean corpuscular hemoglobin concentration (MCHC) and hemoglobin level. We hypothesized that MCHC would be more informative than hemoglobin levels. This prospective, longitudinal, community-based study included 337 participants (108 men and 229 women; age range, 38-87 years) who received evaluations of MCHC, hemoglobin levels and depressive symptom scores (DSS) during baseline and follow-up examinations, which were performed in 2008-2011 and 2010-2012, respectively. MCHC and hemoglobin levels were measured as part of complete blood counts, while DSS was evaluated using the Beck Depression Inventory. Associations were analyzed using linear regression. We found a statistically significant association between baseline MCHC and follow-up DSS (β = −0.69, p = 0.026), which remained statistically significant after controlling for potential confounders (β = −0.71, p = 0.011). Further, when we analyzed the relationship separately for men and women, we observed that it remained stable for women before (β = −1.00, p = 0.014) and after (β = −1.09, p = 0.003) adjusting for confounders. The stable association indicates that MCHC may be superior to hemoglobin level as a prognostic factor for future depressive symptoms in women. MCHC is easy to measure and low MCHC is usually treatable. Therefore, screening and intervention efforts could be targeted at women with low MCHC, who appear to have elevated risks of developing depressive symptoms.

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Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

Cited by 123 publications

References 68 publications

Oxidative Stress and Major Depression

Oxidative Stress and Major Depression

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Association between Mean Corpuscular Hemoglobin Concentration and Future Depressive Symptoms in Women

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