Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory

Lv, Li; Liu, Yunlong; Xie, Junhua; Yan, Wu; Zhao, Jianjian; Li, Qian; Zhong, Yi

doi:10.1038/s41467-019-13236-9

Cited by 34 publications

(40 citation statements)

References 41 publications

(78 reference statements)

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“…Furthermore, it is shown that Rac1 activity mediates reversible forgetting. α2-Chimaerin, through inhibition of Rac1 activity during the maintenance stage, reverses forgetting to sustain memory (Lv et al, 2019).…”

Section: Rac1 Gtpase In Memory Forgettingmentioning

confidence: 99%

The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory

Costa

Dines

Lamprecht

2020

Front. Synaptic Neurosci.

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The ability to form memories in the brain is needed for daily functions, and its impairment is associated with human mental disorders. Evidence indicates that long-term memory (LTM)-related processes such as its consolidation, extinction and forgetting involve changes of synaptic efficacy produced by alterations in neural transmission and morphology. Modulation of the morphology and number of dendritic spines has been proposed to contribute to changes in neuronal transmission mediating such LTM-related processes. Rac GTPase activity is regulated by synaptic activation and it can affect spine morphology by controlling actin-regulatory proteins. Recent evidence shows that changes in Rac GTPase activity affect memory consolidation, extinction, erasure and forgetting and can affect spine morphology in brain areas that mediate these behaviors. Altered Rac GTPase activity is associated with abnormal spine morphology and brain disorders. By affecting Rac GTPase activity we can further understand the roles of spine morphogenesis in memory. Moreover, manipulation of Rac GTPase activity may serve as a therapeutic tool for the treatment of memory-related brain diseases.

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Section: Rac1 Gtpase In Memory Forgettingmentioning

confidence: 99%

The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory

Costa

Dines

Lamprecht

2020

Front. Synaptic Neurosci.

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“…SI has shown to elevate Rac1 activity in hippocampal tissue, inducing social recognition memory (SRM) forgetting and long-term potentiation (LTP) decline in mice; According to this finding, Inhibiting of Rac1 Activity Blocked Progressed Decline of LTP and suppressed forgetting of SRM in isolated adult mice. However, Rac1 activity had no influence on short-term (15-min) memory in the socially isolated period (86).…”

Section: Antidepressant Drugsmentioning

confidence: 83%

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

Taherizadeh¹,

Rahmani²,

Alidadi³

et al. 2021

Preprint

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Objective: During the COVID-19 pandemic, quarantine and staying at home is advised. The social relationship between people has become deficient, and human social isolation (SI) has become the consequence of this situation. It was shown that SI has made changes in hippocampal neuroplasticity, which will lead to poor cognitive function and behavioral abnormalities. There is a connection between SI, learning, and memory impairments. In addition, anxiety-like behavior and increased aggressive mood in long-term isolation have been revealed during the COVID-19 outbreak. Methods: Term searches was done in Google Scholar, Scopus, ScienceDirect, Web of Science and PubMed databases as well as hand searching in key resource journals from 1979–2020. Results: Studies have shown that some drug administrations may positively affect or even prevent social isolation consequences in animal models. These drug treatments have included opioid drugs, anti-depressants, Antioxidants, and herbal medications. In addition to drug interventions, there are non-drug treatments that include an enriched environment, regular exercise, and music. Conclusion: This manuscript aims to review improved cognitive impairments induced by SI during COVID-19.

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“…The results obtained from electrophysiological studies support the roles of Rho GTPases in synaptic transmission and plasticity. For example, increased Rac1 activity, either through KO/knockdown of Rac1 upstream GAP proteins such as alpha-chimaerin and BCR/ABR, or the expression of constitutively active Rac1 mutants, led to unstable theta-burst stimulation (TBS)-induced LTP that gradually decayed to the baseline response at the CA1 synapse ( Oh et al, 2010 ; Liu et al, 2016 , 2018 ; Lv et al, 2019 ). On the other hand, decreased Rac1 activity, either through the expression of dominant negative Rac1 mutants or the upstream GAP protein alpha-chimaerin, or through genetic deletion of MAP1B, resulted in more stable LTP ( Glebov et al, 2015 ; Liu et al, 2016 , 2018 ; Lv et al, 2019 ).…”

Section: Rho Gtpases In Synaptic Plasticitymentioning

confidence: 99%

Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

Zhang

Zablah

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Memory impairments are associated with many brain disorders such as autism, Alzheimer’s disease, and depression. Forming memories involves modifications of synaptic transmission and spine morphology. The Rho family small GTPases are key regulators of synaptic plasticity by affecting various downstream molecules to remodel the actin cytoskeleton. In this paper, we will review recent studies on the roles of Rho proteins in the regulation of hippocampal long-term potentiation (LTP) and long-term depression (LTD), the most extensively studied forms of synaptic plasticity widely regarded as cellular mechanisms for learning and memory. We will also discuss the involvement of Rho signaling in spine morphology, the structural basis of synaptic plasticity and memory formation. Finally, we will review the association between brain disorders and abnormalities of Rho function. It is expected that studying Rho signaling at the synapse will contribute to the understanding of how memory is formed and disrupted in diseases.

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Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory

Cited by 34 publications

References 41 publications

The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory

The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

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