Interplay of miRNAs and lncRNAs in STAT3 signaling pathway in colorectal cancer progression

Abstract

In recent decades, colorectal cancer (CRC) has turned into one of the most widespread malignancies, and the incidence of this malignancy is expected to increase. Despite considerable improvements in therapeutic approaches, the prognosis, and the management of CRC face many problems. Likely, the main limitation in the successful treatment of CRC is the lack of appropriate clinical therapeutic targets. As an effective target, the signal transducer and activator of transcription 3 (STAT3) are regulated by a wide range of genes and involved in cellular processes, including cell growth, migration, invasion, immunosuppression, and angiogenesis. Aberrant regulation of STAT3 signaling leads to cellular dysfunction, diseases, and malignancies, including CRC. Consequently, targeting this signaling pathway is considered one of the therapeutic strategies used in CRC treatment. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are non-coding RNA molecules with partial or no protein-coding activity that participate in gene regulation at epigenetic, transcriptional, and post-transcriptional levels and regulate multiple signaling pathways, including STAT3 signaling (especially JAK/STAT). Therefore, these regulatory molecules are suggested to be very promising targets to present new insights into overcoming the limitations of conventional therapeutic strategies. Therefore, the current review study aimed to summarize the therapeutic and diagnostic significance of miRNAs and lncRNAs and their therapeutic and diagnostic significance related to the expression and activity of STAT3 in CRC.

Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response

“…It has been established that lncRNAs, a class of ncRNA transcripts, are functional components engaged in a variety of biological processes in human malignancies, including angiogenesis, metastasis, apoptosis, and cell survival. According to research, lncRNAs could regulate several important pathways connected to cancer, including the STAT3, PI3K-AKT-mTOR, and Notch pathways [ [111] , [112] , [113] ]. In this paper, we compiled 21 lncRNAs linked to the Wnt/β-catenin pathway in LC, 18 of which are up-regulated and 3 of which are down-regulated.…”

Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review)

“…A growing body of evidence has shown that STAT3 signaling is regulated by, and also regulates an increasing number of, lncRNAs ( 146 - 148 ). A dual relationship exists between lncRNAs and STAT3 signaling as they influence each other to promote cancer progression.…”